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Communications

Open Access

PARP inhibition in ovarian cancer: what is still missing?

  • Matteo Morotti1,2,*,
  • Eleonora Ghisoni1,3

1Ludwig Institute for Cancer Research, Bâtiment AGORA, 1005 Lausanne, Switzerland

2Department of Gynecology, CHUV-Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland

3Department of Oncology, Immuno-Oncology Service, CHUV-Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland

DOI: 10.31083/j.ejgo4301016 Vol.43,Issue 1,February 2022 pp.143-145

Submitted: 11 October 2021 Accepted: 19 November 2021

Published: 15 February 2022

*Corresponding Author(s): Matteo Morotti E-mail: drmorottimatteo@gmail.com

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Matteo Morotti,Eleonora Ghisoni. PARP inhibition in ovarian cancer: what is still missing?. European Journal of Gynaecological Oncology. 2022. 43(1);143-145.

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https://www.ejgo.net/articles/10.31083/j.ejgo4301016

References

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[6] González-Martín A, Pothuri B, Vergote I, DePont Christensen R, Graybill W, Mirza MR, et al. Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. New England Journal of Medicine. 2019; 381: 2391–2402.

[7] Frey MK, Pothuri B. Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literature. Gynecologic Oncology Research and Practice. 2017; 4: 4.

[8] Nguyen L, W. M. Martens J, Van Hoeck A, Cuppen E. Pancancer landscape of homologous recombination deficiency. Nature Communications. 2020; 11: 5584.

[9] Pellegrino B, Mateo J, Serra V, Balmaña J. Controversies in oncology: are genomic tests quantifying homologous recombination repair deficiency (HRD) useful for treatment decision making? ESMO Open. 2019; 4: e000480.

[10] Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, et al. A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients. Clinical Cancer Research. 2018; 24: 4482–4493.

[11] Gulhan DC, Lee JJ, Melloni GEM, Cortés-Ciriano I, Park PJ. Detecting the mutational signature of homologous recombination deficiency in clinical samples. Nature Genetics. 2019; 51: 912–919.

[12] Dias MP, Moser SC, Ganesan S, Jonkers J. Understanding and overcoming resistance to PARP inhibitors in cancer therapy. Nature Reviews Clinical Oncology. 2021; 18: 773–791.

[13] Färkkilä A, Rodríguez A, Oikkonen J, Gulhan DC, Nguyen H, Domínguez J, et al. Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells. Cancer Research. 2021; 81: 2774–2787.

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[16] Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Reports. 2021; 36: 109412.

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