Association of the rs2430561 polymorphism of the interferon-γ gene with cervical cancer susceptibility and prognosis in Han Chinese women

Objectives: To investigate IFN-$\gamma$ rs2430561 polymorphisms in Han women in northeast China and the relationship between the rs2430561 polymorphisms and the risk of cervical cancer. Methods: PCR-ASP was used for genotyping. IFN-$\gamma$ rs2430561 polymorphism was detected in 173 cases of cervical invasive carcinoma and 422 healthy controls in Han women in northeast China. Results: The allele and genotype distributions of the IFN-$\gamma$ rs2430561 polymorphism were not significantly different between each of the groups (P $>$ 0.05). There was no significant relationship between rs2430561 polymorphism and invasive cervical cancer (TT vs AA, OR = 1.321, 95% CI: 0.423–4.121, P = 0.632). The rs2430561 genotype was not associated with major clinicopathological features of invasive cervical cancer (P >$>$ 0.05). The polymorphism had no significant effect on overall survival (P = 0.071) or progression free survival (P = 0.067) of invasive cervical carcinoma. Conclusions: Rs2430561 polymorphism had no effect on invasive cervical cancer susceptibility in Han females in northeastern China, and was not associated with the prognosis of invasive cervical carcinoma.

Cervical cancer; Single nucleotide polymorphism; Genetic susceptibility; IFN-γ

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