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Original Research

Open Access

Expression and clinical significance of CSAD in type I endometrial carcinoma

  • Hao Huang1,†
  • Mengni Wang2,†
  • Xiaojing Chen1
  • Qin Chen3
  • Yan Feng2
  • Baohua Li1,2,*,

1Zhejiang Key Laboratory of Maternal and Infant Health, Women’s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, China

2Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, China

3Department of Pathology, Women’s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, China

DOI: 10.22514/ejgo.2024.110

Submitted: 16 July 2024 Accepted: 28 August 2024

Online publish date: 28 October 2024

*Corresponding Author(s): Baohua Li E-mail: lbh19787@zju.edu.cn

† These authors contributed equally.

Abstract

The current study aimed to identify the expression and clinical significance of cysteine sulfinate decarboxylase (CSAD) in type I endometrial carcinoma (EC). A total of 350 patients with endometrial lesions were involved in the study at Zhejiang University’s Women’s Hospital. Immunochemical staining was performed on samples of normal endometrium (NE), atypical endometrial hyperplasia (AEH), and type I EC. The study evaluated the association of CSAD staining with clinical characteristics and patient survival. CSAD expression in type I EC was elevated in comparison with NE, and increased expression correlates with International Federation of Gynecology and Obstetrics (FIGO) stages, Lymph vascular space invasion (LVSI), and Lymph node metastasis (LNM). High CSAD levels are associated with poor disease-free survival and overall survival. small interfering RNAs (siRNAs) can decrease CSAD expression, inhibit cancer cell proliferation, and affect B-cell lymphoma-2 (BCL-2) and BCL2-Associated X (BAX) protein expression. Our research indicates that higher levels of CSAD expression in type I EC was significantly associated with some clinical variables indicating poor prognosis and survival rate in patients with type I EC. patients and could promote cancer cell growth by affecting cell apoptosis rate.


Keywords

Cysteine sulfinate; Decarboxylase; Type I endometrial carcinoma; Prognosis; Proliferation; Apoptosis


Cite and Share

Hao Huang,Mengni Wang,Xiaojing Chen,Qin Chen,Yan Feng,Baohua Li. Expression and clinical significance of CSAD in type I endometrial carcinoma. European Journal of Gynaecological Oncology. 2024.doi:10.22514/ejgo.2024.110.

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