Efficacy and safety of radiofrequency ablation in the treatment of low-grade squamous intraepithelial lesions complicated with high-risk human papillomavirus infection

This study evaluates the efficacy and safety of radiofrequency ablation (RFA) in treating low-grade squamous intraepithelial lesions (LSIL) with high-risk human papillomavirus (hrHPV) infection. The clinical data of 100 patients with LSIL and hrHPV infection were retrospectively analyzed. Patients were divided into the RFA group and the 5-aminolevulinic acid photodynamic therapy (ALA-PDT) group according to the treatment protocol, with 50 patients per group. Efficacy, negative hrHPV seroconversion, mental status, treatment satisfaction, and the occurrence of adverse reactions were compared between the two groups. The RFA group had a significantly higher total effective rate (94.00%) than the ALA-PDT group (74.00%). At 3 and 6-month follow-ups, the negative hrHPV seroconversion rate was significantly higher in the RFA group than in the ALA-PDT group (p < 0.05). At 6 months after treatment, the RFA group showed significantly lower Self-Rating Anxiety Scale scores and Self-Rated Depression Scale scores and higher satisfaction compared to the ALA-PDT group (all p < 0.05). The incidence of postoperative complications rate was not significantly different between the RFA group and ALA-PDT group (χ2 = 3.184, p = 0.074). RFA is an effective and safe treatment that improves anxiety, depression, and satisfaction in patients with LSIL complicated by hrHPV infection.

LSIL; hrHPV infection; Radiofrequency ablation; Efficacy; Safety

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