Article Data

  • Views 2223
  • Dowloads 146

Case Reports

Open Access

Undifferentiated endometrial sarcoma of the cervix: a case report

  • P.-S. Huang1,6,7
  • C.-T. Yue2
  • W.-Y. Kao3
  • J.-M. Hwang4
  • H.-W. Kuo5
  • S.-C. Huang1,*,

1Department of Obstetrics and Gynecology,Taiwan(China)

2Department of Pathology,Taiwan(China)

3Department of Hematology and Oncology,Taiwan(China)

4Department of Radiation Oncology, Taiwan(China)

5Department of Diagnostic Radiology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, TaipeiTaiwan(China)

6Department of Obstetrics and Gynecology, College of Medicine, Taipei Medical University, Taipei,Taiwan(China)

7Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei ,Taiwan(China)

DOI: 10.12892/ejgo4646.2019 Vol.40,Issue 6,December 2019 pp.1035-1038

Published: 10 December 2019

*Corresponding Author(s): S.-C. Huang E-mail: schuang@tzuchi.com.tw

Abstract

Undifferentiated endometrial sarcoma is an aggressive sarcoma. The authors report a case of such a large tumor arising from the cervix in a 53-year-old multiparous woman presenting with urinary retention and vaginal bleeding. Ultrasound and Doppler imaging revealed a large mass about 13.3×7.6 cm in the cervix. MRI revealed a large polypoid heterogeneous hyperintensity tumor (12.2×8.2 cm) in the cervix with vaginal lumen protrusion and urinary bladder compression. Total abdominal hysterectomy and bilateral salp-ingo-oophorectomy were performed. The pathology revealed FIGO Stage IIb. Adjuvant radiotherapy and chemotherapy with doxorubicin were given. The patient tolerated the treatment well, and so far she has no evidence of recurrence.

Keywords

Undifferentiated endometrial sarcoma; Vaginal bleeding; Hysterectomy.

Cite and Share

P.-S. Huang,C.-T. Yue,W.-Y. Kao,J.-M. Hwang,H.-W. Kuo,S.-C. Huang. Undifferentiated endometrial sarcoma of the cervix: a case report. European Journal of Gynaecological Oncology. 2019. 40(6);1035-1038.

References

[1] D’Angelo E., Prat J.: “Uterine sarcomas: a review”. Gynecol. Oncol., 2010, 116, 131.

[2] Hendrickson M.R., Tavassoli F.A., Kempson R.L., et al.: “Mes-enchymal tumours and related lesions. In: Tavassoli FA, Devilee P,(eds). World Health Organization Classification of Tumours. Pathol-ogy and Genetics of Tumours of the Breast and Female Genital Or-gans. Lyon: IARC Press, 2003, 233.

[3] Chew I., Oliva E.: “Endometrial stromal sarcomas. A review of po-tential prognostic factors”. Adv. Anat. Pathol., 2010, 17, 113.

[4] Tanner E.J., Garg K., Leitao M.M. Jr., Soslow R.A., Hensley M.L.: “High grade undifferentiated uterine sarcoma: surgery, treatment, and survival outcomes”. Gynecol. Oncol., 2012, 127, 27.

[5] Abell M.R., Ramirez J.A.: “Sarcomas and carcinomas of the uterine cervix”. Cancer, 1973, 31, 1176.

[6] Chang K.I., Crabtree G.S., Lim-Tan S.K., Kempson R.L., Hendrick-son M.R.: “Primary extrauterine endometrial stromal neoplasms: a clinicopathologic study of 20 cases and a review of the literature”. Int. J. Gynecol. Pathol., 1993, 12, 282.

[7] Clement P.B., Young R.H., Scully R.E.: “Stromal endometriosis of the uterine cervix. A variant of endometriosis that may simulate sar-coma”. Am. J. Surg. Pathol., 1990, 14, 449.

[8] Prat J.: “FIGO staging for uterine sarcoma”. Int. J. Gynecol. Obstet., 2009, 104, 177.

[9] Gadducci A., Cosio S., Romanini A., Genazzani A.R.: “The man-agement of patients with uterine sarcoma: a debated clinical chal-lenge”. Crit. Rev. Oncol. Hematol., 2008, 65, 129.

[10] Orr B.C., Lin J.F., Edwards R.P., Kelley J.L. III, Olawaiye A.B., Comerci J.T., et al.: “Undifferentiated endometrial sarcoma: Does adjuvant treatment impact outcomes of stage I disease?” Gynecol. Oncol., 2016, 141, 120.

[11] Williams G.A., Richardson A.C.: “Endometriosis of the cervix. Clas-sification and analysis of 17 cases”. Am. J. Obstet. Gynecol., 1961, 81, 111.

[12] Veigo-Ferreira M.M., Leiman G., Dunber F., Margolius K.A.: “Cer-vical endometriosis facilitated diagnosis by fine needle aspiration cytologic testing”. Am. J. Obstet. Gynecol., 1987, 157, 849.

[13] Chen X., Hamele-Bena D., Galic V.L., Liu-Jarin X., Ko Y.C.K., Her-zog T., et al.: ‘Infiltrating adenomyosis of the cervix with features of a low-grade stromal sarcoma: a case report and a literature re-view”. Int. J. Gynecol. Pathol., 2014, 33, 253.

[14] Puliyath G., Nair M.K.: ‘Endometrial stromal sarcoma: A review of the literature”. Indian J. Med. Paediatr. Oncol., 2012, 33, 1.

[15] Shah S.H., Jagannathan J.P., Krajewski K., O’Regan K.N., George S, Ramaiya N.H.: “Uterine sarcomas: then and now”. Am. J. Roentgenol., 2012, 199, 213.

[16] Toprak U., Paşaoğlu E., Karademir M.A., Gülbay M.: “Sonographic, CT, and MRI findings of endometrial stromal sarcoma located in the myometrium and associated with peritoneal inclusion cyst”. Am. J. Roentgenol., 2004, 182, 1531.

[17] Kim J.A., Lee M.S., Choi J.S.: “Sonographic findings of uterine en-dometrial stromal sarcoma”. Korean J. Radiol., 2006, 7, 281.

[18] Tepper R., Altaras M., Goldberger S., Zalel Y., Cordoba M., Beyth Y.: “Color Doppler ultrasonographic findings in low and high grade endometrial stromal sarcomas”. J. Ultrasound Med., 1994, 13, 817.

[19] Rha S.E., Byun J.Y., Jung S.E., Lee S.L., Cho S.M., Hwang S.S., et al.: “CT and MRI of Uterine Sarcomas and Their Mimickers”. Am. J. Roentgenol., 2003, 181, 1369.

[20] Nucci M.R., Harburger D., Koontz J., Dal Cin P., Sklar J.: “Molec-ular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluo-rescence in situ hybridization in endometrial stromal neoplasms”. Am. J. Surg. Pathol., 2007, 31, 65.

[21] Lange S.S., Novetsky A.P., Powell M.A.: “Recent advances in the treatment of sarcomas in gynecology”. Discov. Med., 2014, 18, 133.

[22] Amant F., De Knijf A., Van Calster B., Leunen K., Neven P., Berteloot P., et al.: “Clinical study investigating the role of lym-phadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma”. Br. J. Cancer, 2007, 97, 1194.

[23] Reed N.S., Mangimni C.. Malmstrom H., Scarfone G., Poveda A., Pecorelli S., et al.: “Phase III randomized study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcoma stage I and IIL an European Organization for Research and Treat-ment of Cancer Gynaecological Cancer Group Study (protocol 55874)”. Eur J. Cancer, 2008, 44, 808.

Submission Turnaround Time

Top