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Original Research

Open Access

Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell

  • N. A. Abdullah1
  • P. N. Wang2
  • K. G. Huang3,*,
  • A. S. Adlan4
  • J. Casanova5

1Department of Obstetrics & Gynecology, Sultanah Bahiyah Hospital, Kedah (Malaysia)

2Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan (Taiwan)

3Department of Obstetrics and Gynecology Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan (Taiwan)

4Department of Obstetrics and Gynecology. University Malaya Medical Center, Faculty of Medicine, University of Malaya, Kuala Lumpur (Malaysia)

5Department of Obstetrics & Gynecology, Centro Hospitalar do Porto, Porto (Portugal)

DOI: 10.12892/ejgo340217 Vol.34,Issue 2,March 2013 pp.183-185

Published: 24 March 2013

*Corresponding Author(s): K. G. Huang E-mail: kghuang@ms57.hinet.net

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Abstract

A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient’s disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy.

Keywords

High-dose chemotherapy; Germ cell tumor; Autologous stem cell.

Cite and Share

N. A. Abdullah, P. N. Wang, K. G. Huang, A. S. Adlan, J. Casanova. Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. European Journal of Gynaecological Oncology. 2013; 34(2): 183-185. doi: 10.12892/ejgo340217

URL:

https://www.ejgo.net/articles/10.12892/ejgo340217

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