Article Data

  • Views 661
  • Dowloads 151

Reviews

Open Access

Fertility preservation in women with early stage cervical cancer. Review of the literature


  • I. Boutas1,*,
  • C. Sofoudis1
  • E. Kalampokas1
  • C. Anastasopoulos1
  • T. Kalampokas1
  • N. Salakos1

12nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Department of Gynecological Oncology, Athens (Greece)

DOI: 10.12892/ejgo24442014 Vol.35,Issue 4,July 2014 pp.373-377

Published: 10 July 2014

*Corresponding Author(s): I. Boutas E-mail: ioannis.boutas@gmail.com

Abstract

Within the last decades, the percentage of diagnosed cervical cancer in women of reproductive age has increased. The possibility of diagnosing small cervical tumors (≤ twocm) in childbearing age, can be explained due to the fact that many women, are aware of the benefits of Pap smear or colposcopy examination. Many demand a more conservative policy to handle such lesions in order to have an uneventful pregnancy in the near future.

Keywords

Cervical cancer; Trachelectomy; Fertility.

Cite and Share

I. Boutas,C. Sofoudis,E. Kalampokas,C. Anastasopoulos,T. Kalampokas,N. Salakos. Fertility preservation in women with early stage cervical cancer. Review of the literature. European Journal of Gynaecological Oncology. 2014. 35(4);373-377.

References

[1] American Cancer Society: “Cancer Facts and figures 2009”. Available at www.cancer org (assessed July 9, 2009).

[2] Arbyn M., Autier P., Ferlay J.: “Burden of cervical cancer in the 27 members states of the European Union: estimates for 2004”. Ann. Oncol., 2007, 18, 1423.

[3] Schauta F.: “Die Operation des gebar mutter krebes mittels des schuchardt schen paravaginatschmittes” (in German). Monatsschr. Geburtshilfe Gynakol., 1902, 15, 133.

[4] Wertheim E.: “Zur frag de frag de radi raloperation beam uterus krebs” (in German)”. Arch. Gynakol., 1900, 61, 627.

[5] Novak F.: “Radical abdominal subcorporeal extirpation of the cervix with bilateral pelvic lymph node dissection in cancer in situ of the cervix uteri” Acta Medica Jugoslavica, 1952, 6, 1.

[6] Aburel E.: “In Chirurgia Cinecologica Technica: Si Cartica Operatiorie”. II Sub Redaetia Panait Sirbu, 2nd ed Editura Medicola Bu-curesti 1976

[7] Burghardt E., Holzer E.: “Diagnosis and treatment of micro-invasive carcinoma of the cervix uteri”. Obstet. Gynecol., 1977, 49, 641.

[8] Dargent D., Brun JL., Roy M.: “La trachelectomie elargie: une alternative a l’hysterectomie radicate dans traitment des cancers infiltrants”. Jobgyn., 1994, 2, 285.

[9] Shepherd J.H., Crawford R.A.F., Oram D.H.: “Radical trachelectomy: a way to preserve fertility in the treatment or early cervical cancer?” Br. J. Obstet. Geynaecol., 1998, 105, 912.

[10] Plante M., Renaud MC., Harel F., Roy M.: “Vaginal radical trachelectomy: an oncologically safe fertility-preserving surgery, an updated series of 72 cases and review of the literature”. Gynecol. Oncol., 2004, 94, 614.

[11] Covens A., Shaw P., Murphy J., DePetrillo D., Lickrish G., Laframboise S., Rosen B.: “Is radical trachelectomy a safe alternative to radical hysterectomy for patients with stage IA-B carcinoma of the cervix?” Cancer, 1999, 86, 2273.

[12] Schlaerth J.B., Spirtos N.M., Schlaerth A.C.: “Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer”. Am. J. Obstet. Gynecol., 2003, 188, 29.

[13] Burnett A.F., Roman L.D., O’Meara A.T., Morrow C.P.: “Radical vaginal trachelectomy and pelvic lymphadenectomy for preservation f fertility in early cervical carcinoma”. Gynecol. Oncol., 2003, 88, 419.

[14] Roman L.D.: “Pregnancy after radical vaginal trachelectomy maybe not such a risky undertaking after all”. Gynecol. Oncol., 1994, 52, 105.

[15] Ungar L., Palfavi L., Hogg R., Siklos P., Boyle D.C., Del Priore G., Smith J.R.: “Abdominal radical trachelectomy: a fertility preserving option for women with early stage cervical cancer”. Br. J. Obstet. Gynecol., 2005, 112, 366.

[16] Heller P.B., Maletano J.H., Bundy B.N., Barnhill D.R., Okagaki T.: “Clinical pathologic study of stage 2B, 3 and 4A carcinoma of the cervix; extended diagnostic evaluation for paraortic node metastases: A gynecological oncology group study”. Gynecol. Oncol., 1990, 38, 425.

[17] Baumgartnel B.R., Bernardino M.E.: “MIR imaging of the cervix: off axis scan to improve visualization as a zonal anatomy”. AJR Am J Roentgenol., 1989, 153, 1001.

[18] Peppercorn D.P., Jeyahraja, Woollas R.: “The role of MRI in the selection of patients with early cervical carcinoma for fertility-sparing surgery: initial experience” Radiology, 1999, 212, 395.

[19] Charles-Edwards E., Morgan V., Attygalle A., Giles SL., Ind TE., Davis M., et al.: “Endovaginal magnetic resonance imaging stage 1A/1B1 cervical cancer with a T2-and diffusion-weighted magnetic resonance technique: effect of lesion size and previous cone biopsy on tumour detectability”. Gynecol. Oncol., 2011, 120, 368.

[20] Rose P.G., Adler L.P., Rodriguez M., Faulhaber P.F., Abdul-Karim F. W., Miraldi F.: “Positron omission tomography for evaluating paraaortic nodule metastases in locally advanced cervical cancer before surgical staging: a surgicopathologic study”. J. Clin. Oncol., 199, 17, 41.

[21] Lakhman Y., Akin O., Park K.J., Sarasohn D.M., Zheng J., Goldman D. A., et al.: “Stage IB1 cervical cancer: role of preoperative MR imaging in selection of patients for fertility-sparing radical trachelectomy”. Radiology, 2013, 269, 149. doi: 10.1148/radiol.13121746. Epub 2013 Jun 20.

[22] Sahdev A., Wenaden A.E.T., Sohaib S.A., Shepherd J.H., Reznek R. H.: “Magnetic resonance imaging in gynecological malignancies”. Cancer Imaging, 2005, 5, 539.

[23] Malur S., Craus E.N., Kohler C., Schneider A.: “Sentinel lymph node dissection in patients with cervical cancer”. Gynecol. Oncol., 2001, 80, 254.

[24] Dargent D., Martin X., Mathevet P.: “Laparoscopic assessment of sentinel lymph node in early stage cervical cancer”. Gynecol. Oncol., 2001, 79, 411.

[25] Van Trappen P.O., Gysleman V.O., Lowe D.G.: “Molecular qualification and mapping pf lymph node micro-metastases in cervical cancer”. Lancet, 2001, 357, 15.

[26] Plante M., Renaud C., Tetu B., Harel F., Roy M.: “Laparoscopic sentinel node mapping in early stage cervical cancer”. Gynecol. Oncol., 2003, 91, 494.

[27] Rockall A.G., Sohaib S.A., Harisinghani N.G., Babar S.A., Singh N., Jeyarajah A.R., et al.: “Diagnostic performance of nano particle-enhanced MRI in the diagnosis of lymph node metastasis in patients with endometrial and cervical cancer”. J. Clin. Oncol., 2005, 23, 2813.

[28] Plante M.: “Vaginal radical trachelectomy: an update”. Gynecol. Oncol., 2008, 111, 105.

[29] Carter J., Sonoda Y., Chi DS., Raviv L., Abu-Rustum N.R.: “Radical trachelectomy for cervical cancer, postoperative physical and emotional adjustment concerns”. Gynecol. Oncol., 2008, 111, 151.

[30] Carter J., Sonoda Y., Chi D.S., Raviv L., Abu-Rustum N.R.: “Radical trachelectomy for cervical cancer, postoperative physical and emotional adjustment concerns”. Gynecol. Oncol., 2008, 111, 151.

[31] Shepherd J.H., Spencer C., Herod J., Ind T.E.: “A radical vaginal trachelectomy as a fertility-sparing procedure in women with earlystage cervical cancer- cumulative pregnancy rate in a series of 123 women”. Br. J. Obstet. Gynecol., 2006, 113, 719.

[32] Burnett A.F., Roman L.D., O’Meara A.T., Morrow C.P.: “Radical vaginal trachelectomy and pelvic lymphadenectomy for preservation of fertility in early cervical carcinoma”. Gynecol. Oncol., 2003, 88, 419.

[33] Mathevet P., Laszlo de Kaszon E., Dargent D.: “Fertility preservation in early cervical cancer”. Gynecol. Obstet. Fertil., 2003, 31, 706.

[34] Pecorelli S.: “Cancer of the cervix uteri”. Int. J. Gynecol. Obstet., 2000, 70, 37.

[35] Pecorelli S., Odicino F.: “Cervical cancer staging” Cancer, 2003, 9, 390.

[36] Leitao M.M. Jr., Chi D.S.: “Fertility sparing options for patients with gynecologic malignancies” Oncologist, 2005, 10, 613.

[37] Trimble E.L., Harlan L.C., Clegg L.X.: “Untreated cervical cancer in the United States”. Gynecol. Oncol., 2005, 96, 271.

[38] Diaz J.P., Sonoda Y., Leitao M.M., Zivanovic O., Brown C.L., Chi D. S., et al.: “Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma” Gynecol. Oncol., 2008, 111, 255.

[39] Jemal A., Bray F., Center M.M., Ferlay J., Ward E, Forman D.: “Global cancer statistics”. CA Cancer J. Clin., 2011, 61, 69.

[40] Canter J., Sonoda Y., Baser R.E., Raviv L., Chi D.S., Barakat R.R., et al.: “A 2-year prospective study assessing the emotional sexual and quality of life concerns of women undergoing radical trachelectomy versus radical hysterectomy for treatment of early-stage cervical cancer” Gynecol. Oncol., 2010, 199, 358.

[41] Sonoda Y., Abu-Rustum NR., Gemignani ML., Chi DS., Brown CL., Poynor EA., Barakat RR. “A fertility-sparing alternative to radical hysterectomy: how many patients may be eligible?”. Gynecol. Oncol., 2004, 95, 534.

[42] Gerhenson D.M.: “Fertility-sparing surgery for malignancies in women”. J. Natl. Cancer Inst. Monogr., 2005, 34, 43.

[43] Abu-Rustum N.R., Neubauer N., Sonoda Y., Park K.J., Gemingnani M., Alektiar K.M. et al.: “Surgical and pathologic outcomes of fertility-sparing radical abdominal trachelectomy for FIGO stage IB1 cervical cancer”. Gynecol. Oncol., 2008, 111, 261.

[44] Marchiole P., Benchaib M., Buenerd A., Lazlo E., Dargent D., Mathevet P.: “Oncological safety of laparoscopic-assisted vaginal radical trachelectomy (LARVT or Dargent’s operation): a comparative study with laparoscopic-assisted vaginal radical hysterectomy (LARVH). Gynecol. Oncol., 2007, 106, 132.

[45] Shepherd J.H., Croford R.A., Oram D.H.: “Radical trachelectomy in early stage carcinoma of the cervix: outcome as judged by recurrence and fertility rates”. Br. J. Obstet. Gynecol., 2001, 108, 882.

[46] Dargent D.: “Radical trachelectomy: an operation that preserves the fertility of young women with invasive cervical cancer” Bull. Acad. Natl. Med., 2001, 185, 1295 (in French).

[47] Burnett A.F., Roman L.D., O’Meara., Morrow C.P.: “Radical vaginal trachelectomy and pelvic lymphadenectomy for preservation of fertility in early cervical carcinoma”. Gynecol. Oncol., 2003, 88, 419.

[48] Plante M., Renaud MC., Francois H., Roy M.: “Vaginal radical trachelectomy: an oncologically safe fertility-preserving surgery. An updated series of 72 cases and review of the literature”. Gynecol. Oncol., 2004, 94, 614.

[49] Bernardini M., Barret J., Seaward G., Covens A.: “Pregnancy outcomes in patients with radical trachelectomy”. Am. J. Obstet. Gynecol., 2003, 189, 1378.

[50] Sahdev A., Sohaib SA., Wenaden A.E., Shepherd J.H., Reznek R.H.: “The performance of magnetic resonance imaging in early cervical carcinoma: a long-term experience”. Int. J. Gynecol. Cancer, 2007, 17, 629.

[51] Peppercorn P.D., Jeyarajah A.R., Woolas R., Shepherd J.H., Oram D. H., Jacobs I.J., et al.: “Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience” Radiology, 1999, 212, 395.

[52] Plante M., Renaud MC, Roy M.: “Vaginal radical trachelectomy”. In: Levine D.A, Barakat R.R., Hoskins W.J. (eds). Atlas of procedures in gynecologic oncology. London: Martin Dunitz, 2003, 207.

[53] Hauspy J., Beiner M., Harley I., Erlich L., Rasty G., Covens A.: “Sentinel lymph nodes in early stage cervical cancer”. Gynecol. Oncol., 2007, 105, 285

[54] Klemm P., Tozzi R., Kohler C., Hertel H., Schneider A.: “Does radical trachelectomy influence uterine blood supply?”. Gynecol. Oncol., 2005, 96, 283.

[55] Beiner M.E., Covens A.: “Surgery insight: radical vaginal trachelectomy as a method of fertility preservation for cervical cancer”. Nat. Clin. Pract. Oncol., 2007, 4, 353.

[56] Milliken D.A., Shepherd J.H.: “Fertility preserving surgery for carcinoma of the cervix”. Curr. Opin. Oncol., 2008, 20, 575.

[57] Covens A., Shaw P., Murphy J., DePetrillo D., Lickrish G., Laframboise S., et al.: “Is radical trachelectomy a safe alternative to radical hysterectomy for patients with stage IA-B carcinoma of the cervix?”. Cancer ,1999, 86, 2273.

[58] Schlaerth J.B., Spiritos N.M., Schlaerth A.C.: “Radical vaginal trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer”. Am. J. Obstet. Gynecol., 2003, 188, 29.

[59] Mathevet P., Laszlo de Kaszon E., Dargent D.: “Fertility preservation in early cervical cancer”. Gynecol. Obstet. Fertil., 2003, 31, 706.

[60] Plante M., Renaud M.C., Hoskins IA., Roy M.: “Vaginal radical trachelectomy: a valuable fertility-preservation option in the manage-ment of early-stage cervical cancer. A series of 50 pregnancies and review of the literature” Gynecol. Oncol., 2005, 98, 3.

[61] Lee S.J., Schover L.R., Partidge A.H., Patrizio P., Wallace W.H., Hagerty K., et al.: “American Society of Clinical Oncology recom-mendations on fertility preservation in cancer patients”. J. Clin. Oncol., 2006, 24, 2917.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top