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Original Research

Open Access

Clinical outcomes of adjuvant chemotherapy and vaginal brachytherapy with or without pelvic radiation for surgical Stage I-II uterine serous carcinoma

  • J.R. Robbins1
  • M.S. Siddiqui1
  • Z. Al-Wahab2
  • B. Laser1
  • M. Lu3
  • R. Ali-Fehmi4
  • A. Munkarah5
  • M.A. ELSHAIKH1,*,

1Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI, USA

2Department of Obstetrics and Gynecology. Wayne State University School of Medicine Detroit, MI, USA

3Public Health Science, Henry Ford Hospital, Detroit, MI, USA

4Department of Pathology, Wayne State University School of Medicine Detroit, MI, USA

5Division of Gynecologic Oncology, Department of Women’ Health Services. Henry Ford Hospital, Detroit, MI, USA

DOI: 10.12892/ejgo201205449 Vol.33,Issue 5,September 2012 pp.449-454

Published: 10 September 2012

*Corresponding Author(s): M.A. ELSHAIKH E-mail: melshai1@hfhs.org

Abstract

Objective(s): To evaluate the benefit of adding pelvic radiation treatment (EBRT) to vaginal cuff brachytherapy (VB) for women with early stage uterine serous carcinoma (USC) treated with adjuvant chemotherapy. Materials and Methods: After institutional review board (IRB) approval, the authors retrospectively identified 56 patients with 2009 International Federation of Gynecology and Obstetrics (FIGO) Stage I-II USC treated with hysterectomy, bilateral oophorectomy +/- lymphadenectomy, adjuvant chemotherapy, and radiation therapy with either VB alone (n = 33) or VB + EBRT (n = 23) between July 1998 and August 2009. Results: Median age and follow-up were 68.5 years and 54 months respectively. Median VB alone surface dose was 37.5 Gy and median pelvic EBRT dose was 45 Gy. The prevalence of lower uterine segment involvement, > 50% myometrial invasion, and Stage II disease were higher for patients receiving VB+EBRT. Overall, only one vaginal recurrence was observed. Pelvic recurrence rate was 26% for VB + EBRT compared to 12% for VB alone (p = 0.179). The five-year recurrence-free survival (RFS) was 80.5% for VB vs 67.3% for VB + EBRT (p = 0.3847), and the five-year overall survival (OS) was 65.9% for VB vs 66.7% for VB + EBRT (p = 0.7159). On univariate and multivariate analysis, radiation treatment modality was not a predictor for local control or survival. Conclusions: In this cohort, there was no significant clinical benefit of adding pelvic EBRT to the adjuvant management of early stage uterine serous carcinoma. The higher prevalence of high-risk features in the VB + EBRT group may underestimate the value of this treatment. Further investigation is warranted to identify the optimal radiation treatment regiment for early stage USC treated with surgery and adjuvant chemotherapy.

Keywords

Endometrial carcinoma; Serous; Brachytherapy; Adjuvant; Radiation treatment

Cite and Share

J.R. Robbins,M.S. Siddiqui,Z. Al-Wahab,B. Laser,M. Lu,R. Ali-Fehmi,A. Munkarah,M.A. ELSHAIKH. Clinical outcomes of adjuvant chemotherapy and vaginal brachytherapy with or without pelvic radiation for surgical Stage I-II uterine serous carcinoma. European Journal of Gynaecological Oncology. 2012. 33(5);449-454.

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