Distribution of human papillomavirus types in Turkish women

Purpose of investigation: Since oncogenic types of human papillomavirus (HPV) are associated with a higher risk of cervical cancer and certain types can be controlled by a vaccine, a study has been performed to determine the HPV genotype distribution among Turkish women. Methods: The study included patients with abnormal cytology or in the follow-up for cervical intraepithelial neoplasia between 2002 and 2009 at Hacettepe University Hospital. The results of 1,797 consecutive cervical samples were analyzed retrospectively. INNO-LiPA HPV genotyping, HPV-Typing and Seeplex HPV 18-plex genotyping tests were used to determine the types of HPV. Results: HPV was detected in 404 (22.4%) of 1,797 samples studied. HPV DNA was identified in 194 cases by using HPV-Typing test but the specific genotype was not available. The most frequent genotype was HPV 16 which was observed in 103 cases (49.0%). Conclusion: HPV 16 was the most common genotype observed among Turkish women with abnormal cytology. It suggests that HPV vaccination may be useful for prevention of cervical cancer in this population.

Human papillomavirus; Cervical cancer; Pap test; Genotyping

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