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Original Research

Open Access

Metastasis from breast cancer to an endometrial polyp; treatment options and follow-up. Report of a case and review of the literature

  • A.B. Hooker1,*,
  • C.M. Radder1
  • B. van de Wiel3
  • M.M. Geenen2

1Department of Obstetrics and Gynaecology, St. Lucas Andreas Hospital, Amsterdam, The Netherlands

2Department of Internal Medicine/Oncology, St. Lucas Andreas Hospital, Amsterdam, The Netherlands

3Pathology Department, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, The Netherlands

DOI: 10.12892/ejgo201102228 Vol.32,Issue 2,March 2011 pp.228-230

Published: 10 March 2011

*Corresponding Author(s): A.B. Hooker E-mail: a.hooker@slaz.nl

Abstract

Introduction: The female genital tract is rarely involved by metastatic tumors. The most common anatomic locations are the ovaries and the vagina. A case is presented of metastatic breast carcinoma to the vulva and endometrial polyp, both exceptional. Case report: We report the case of an 83-year-old female who presented with vaginal bleeding. Lobular breast carcinoma was diagnosed earlier and during follow-up vulvar metastasis was detected. Hysteroscopic examination because of postmenopausal bleeding revealed an endometrial polyp which was resected. The morphology and immunohistochemistry of the polyp were consistent with lobular breast cancer: metastatic breast cancer to an endometrial polyp. After reviewing the literature 15 cases of metastatic breast carcinoma to endometrial polyps have been reported. The clinical presentation and course, risk factors, treatment and follow-up are discussed. Conclusion: Metastasis of a breast carcinoma to the vulva and an endometrial polyp are extremely rare, but clinicians should be aware of both phenomena.

Keywords

Breast cancer; Uterine metastasis; Endometrial polyp; Treatment; Follow-up

Cite and Share

A.B. Hooker,C.M. Radder,B. van de Wiel,M.M. Geenen. Metastasis from breast cancer to an endometrial polyp; treatment options and follow-up. Report of a case and review of the literature. European Journal of Gynaecological Oncology. 2011. 32(2);228-230.

References

[1] Mazur M.T., Hsueh S., Gersell D.J.: “Metastases to the female genital tract. Analysis of 325 cases”. Cancer, 1984, 53, 1978.

[2] Kumar N.B., Hart W.R.: “Metastases to the uterine corpus from extragenital cancers. A clinopathological study of 63 cases”.Cancer, 1982, 50, 2163.

[3] Perrone G., Altomare V., Zagami M., Vulcano E., Muzii L., Battista

C. et al.: “Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review”. In Vivo, 2009, 23, 629.

[4] Sullivan L.G., Sullivan J.L., Fairey W.F.: “Breast carcinoma metastatic to endometrial polyp”. Gynecol. Oncol., 1990, 39, 96.

[5] Corley D., Rowe J., Curtis M.T., Hogan W.M., Noumoff J.S., Livolsi V.A.: “Postmenopausal bleeding from unusual endometrial polyps in women on chronic tamoxifen therapy”. Obstet. Gynecol., 1992, 79, 111.

[6] Aranda F.I., Laforga J.B., Martinez M.A.: “Metastasis from breast lobular carcinoma to an endometrial polyp. Report of a case with immunohistochemical study”. Acta Obstet. Gynecol. Scand., 1993, 72, 585.

[7] Kennebeck C.H., Alagoz T.: “Signet ring breast carcinoma metastases limited to the endometrium and cervix”. Gynecol. Oncol., 1998, 71, 461.

[8] Martinez-Montero I., Dominguez-Cunchillos F., Muruzabal J.C., Miguel de C., Recari E., Ezcurdia M.: “Uterine metastases from breast cancer”. Acta Obstet. Gynecol. Scand., 1999, 78, 165.

[9] Lambot M.A., Eddafali B., Simon P., Fayt I., Noël J.C.: “Metastasis from apocrine carcinoma of the breast to an endometrial polyp”. Virchows Arch., 2001, 438, 517.

[10] Horn L.C., Einenkel J., Baier D.: “Endometrial metastasis from breast cancer in a patient receiving tamoxifen therapy”. Gynecol. Obstet. Invest., 2000, 50, 136.

[11] Alvarez C., Ortiz-Rey J.A., Estévez F., de la Fuente A.: “Metastatic lobular breast carcinoma to an endometrial polyp diagnosed by hysteroscopic biopsy”. Obstet. Gynecol., 2003, 102, 1149.

[12] Houghton J.P., Ioffe O.B., Silverberg S.G., McGrady B., McCluggage W.G.: “Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen associated polypoid uterine lesions”. Mod. Pathol., 2003, 16, 395.

[13] Al-brahim N., Elavathil L.J.: “Metastatic breast lobular carcinoma to tamoxifen-associated endometrial polyp: case report and literature review”. Ann. Diagn. Pathol., 2005, 9, 166.

[14] Acikalin M.F., Oner U., Tekin B., Yakuz E., Cengiz O.: “Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp”. Gynecol. Oncol., 2005, 97, 946.

[15] Manipadam M.T., Walter N.M., Selvamani B.: “Lobular carcinoma metastasis to endometrial polyp unrelated to tamoxifen. Report of a case and review of the literature”. APMIS, 2008, 116, 538.

[16] Aydin O., Bagci P., Akyildiz E.U., Ozguroglu M., Ilvan S.: “Metastasis from breast carcinoma to endometrial polyp”. Eur. J. Gynaecol. Oncol., 2008, 29, 666.

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