The columnar epithelium hypothesis of cervical carcinogenesis

Cervix; HPV; Transformation zone; Carcinogenesis

[1] Frazer I.H.: “Prevention of cervical cancer through papillomavirus vaccination”. Nat. Rev. Immuno., 2004, 4, 46.

[2] Reich O., Pickel H., Regauer S.: “Why do human papillomavirus infections induce sharply demarcated lesions of the cervix?”. J. Lower Gen. Tract Dis., 2008, 12, 8.

[3] Reich O., Pickel H., Tamussino K., Winter R.: “Microinvasive carcinoma of the cervix: site of first focus of invasion”. Obstet. Gynecol., 2001, 97, 890.

[4] Martens J.E., Smedts F.M., Ploeger D., Helmerhorst T.J.M., Ramaekers F.C.S., Arends J.W. et al.: “Distribution pattern and marker profile show two subpopulations of reserve cells in the endocervical canal”. Int. J. Gynecol. Pathol., 2009, 28, 381.

[5] Vinokurova S., Wentzensen N., Einenkel J., Klaes R., Ziegert C., Melsheimer P. et al.: “Clonal history of papillomavirus-induced dysplasia in the female lower genital tract”. J. Natl. Cancer Inst., 2005, 97, 1816.

[6] Martens J.E., Arends J., Van der Linden P.J., De Boer B.A., Helmerhosrst T.J.: “Cytokeratin 17 an p63 are markers of the HPV target cell, the cervical stem cell”. Anticancer Res., 2004, 24, 771.