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Original Research

Open Access

High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma - report of two cases

  • O. Reich1,*,
  • S. Regauer2
  • S. Scharf3

1Departments of 1Obstetrics and Gynecology , Austria

2Institute of Pathology, Medical University of Graz, Austria

3,Austria

4Institute of Pathology, Medical University of mweltbundesamt Vienna , Austria

Academic Editor: O. Reich

DOI: 10.12892/ejgo201001105 Vol.31,Issue 1,January 2010 pp.105-106

Published: 10 January 2010

*Corresponding Author(s): O. Reich E-mail: olaf.reich@meduni-graz.at

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Abstract

Background: Endometrial stromal sarcomas (ESS) are rare uterine tumors with unknown etiological risk factors, but estrogedependent growth promotion. Cases: We present two patients with advanced ESS, who had increased levels of p,p-DDE; hexachlorobenzene; PCB 28; PCB 52; PCB 101; PCB 138; PCB 153 and PCB 180 in abdominal adipose tissue. Other xenoestrogens were within expected limits for the non-exposed European population. Conclusion: Increased levels of xenoestrogens in patients with ESS may be involved in the pathogenesis of ESS. Chronic exposure to xenoestrogens may be a risk factor for tumor progression.

Keywords

Endometrial stromal sarcoma; Estrogen; Xenoestrogen; Pathogenesis.

Cite and Share

O. Reich,S. Regauer,S. Scharf. High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma - report of two cases. European Journal of Gynaecological Oncology. 2010. 31(1);105-106.

URL:

https://www.ejgo.net/articles/10.12892/ejgo201001105

References

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[3] Louis G.M., Weiner J.M., Whitcomb B.W., Sperrazza R., Schisterman E.F., Lobdell D.T. et al.: “Enviromental PCB exposure and risk of endometriosis”. Hum. Reprod., 2005, 20, 279.

[4] Carozza S.E., Li B., Wang Q., Horel S., Cooper S.: “Agricultural pesticides and risk of childhood cancers”. Int. J. Hyg. Environ. Health, 2009, 212, 186.

[5] Cook I.: “Dioxin-like PCB congener levels in adipose tissue samples from Turkish men”. Organohalogen Compounds, 2006, 68, 117.

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[7] Reich O., Regauer S., Urdl M.: “Estrogen and progesterone receptor content in low-grade-stromal sarcomas”. Br. J. Cancer, 2000, 82, 1030.

[8] Martucci C.P., Fishman J.: “P450 enzymes of estrogen metabolism”. Pharmacol. Ther., 1993, 57, 237.

[9] McGee T.D., Edwards J., Roitberg A.E.: “Preliminary molecular dynamic simulations of the estrogen receptor alpha ligand domain from antagonist to apo”. Int. J. Environ. Res. Public Health, 2008, 5, 111.

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