Article Data

  • Views 392
  • Dowloads 106

Reviews

Open Access

Immature teratoma in pregnancy: a case report and literature review

  • A. Daponte1,*,
  • E. Kostopoulou2
  • A. Zavos1
  • H. Skentou1
  • A. Kallitsaris1
  • G. Koukoulis2
  • I.E. Messinis1

1Department of Obstetrics and Gynecology, Greece

2Department of Pathology, University Hospital of Larissa, Greece

DOI: 10.12892/ejgo200803300 Vol.29,Issue 3,May 2008 pp.300-304

Published: 10 May 2008

*Corresponding Author(s): A. Daponte E-mail: dapontea@otenet.gr

Abstract

Background: The management of a Stage I immature teratoma during pregnancy with a review of the literature is reported. Case Report: A growing adnexal mass was removed at 12 weeks of gestation. Although the frozen section was negative, because of intraoperative clinical suspicion, a right salpingo-oophorectomy and surgical staging were performed. Histological examination revealed a Stage la, grade I immature ovarian teratoma. Appropriate surgical staging enabled avoidance of chemotherapy despite the unexpected histological diagnosis. The pregnancy was terminated because of fetal distress, with cesarean section at 34 weeks of gestation. At that time the peritoneal cavity was inspected and biopsies were taken as in second-look laparotomy. Two years after the first operation the patient remains disease free. Conclusion: For adnexal masses removed during pregnancy frozen section is useful but when there is clinical suspicion surgical staging must be performed.

Keywords

Immature teratoma; Pregnancy; Adnexal mass in pregnancy; Explorative laparotomy; Surgical staging

Cite and Share

A. Daponte,E. Kostopoulou,A. Zavos,H. Skentou,A. Kallitsaris,G. Koukoulis,I.E. Messinis. Immature teratoma in pregnancy: a case report and literature review. European Journal of Gynaecological Oncology. 2008. 29(3);300-304.

References

[1] Sivanesaratnam V.: “Gynaecological malignancies in pregnancy”. In: Ratnam S.S., Sen D.K., Ng S.C., Arulkumaran S., (eds.), Contributions to Obstetrics and Gynaecology, Singapore: Churchill Livingstone, Longman Singapore Publishers (Pvt. Ltd.), 1994, 295.

[2] Di Saia P.J., Creasman W.T. (eds.). Clinical Gynecologic Oncology (6th edn.), St. Louis, MO, Mosby, 2002, 362, 446.

[3] Quesada G., Velasco M.C., Palencia R., Marina C., Garcia M., Marina J. et al.: “Immature teratoma of the ovary during pregnancy”. J. Gynecol. Surg., 2000, 16, 161.

[4] Klein J.: “Pregnancy complicated by teratoma of the ovary”. Obstet. Gynecol., 1954, 3, 93.

[5] Robboy S., Scully R.: “Ovarian teratoma with glial implants on the peritoneum”. Hum. Pathol., 1970, 1, 643.

[6] Montz F.J., Horenstein J., Platt L.D., d'Ablaing G., Schlaerth J.B., Cunningham G.: “The diagnosis of immature teratoma by maternal serum alpha-fetoprotein screening”. Obstet. Gynecol., 1989, 73, 522.

[7] Charles G., Marhic C., Ponties J.E., Meyran M.: “Advanced cancer of the ovary and pregnancy. Apropos of 2 cases”. J. Gynecol. Obstet. Biol. Reprod. (Paris), 1989, 18, 61.

[8] Christman J.E., Teng N.N., Lebovk G.S., Sikic B.C.: “Delivery of a normal infant following cisplatin, vinblastine, and bleomycin (PVB) chemotherapy for malignant teratoma of the ovary during pregnancy”. Gynecol. Oncol., 1990, 37, 292.

[9] Poremba C., Dockhorn-Dworniczak B., Merritt V., Li C.Y., Heidl G., Tauber P.F. et al.: “Immature Teratomas of different origin carried by a pregnant mother and her fetus”. Diagn. Mol. Pathol., 1993, 2, 131.

[10] O’Connor D.M., Norris H.J.: “The influence of grade on the outcome of Stage I ovarian immature (malignant) teratomas and the repioducibility of grading”. Int. J. Gynecol. Pathol., 1994, 13, 283.

[11] Whitecar P., Turner S., Higby K.: “Adnexal masses in pregnancy: A review of 130 cases undergoing surgical management”. Am. J. Obstet. Gynecol., 1999, 181, 19.

[12] Kishimoto K., Ito K., Furukawa M., Ogasawara N., Matsunaga N., Nawata S. et al.: “Immature teratoma with gliomatosis peritonei associated with pregnancy”. Abdom. Imaging, 2002, 27, 96.

[13] Agarwal N., Parul, Kriplani A., Bhatla N., Gupta A.: “Management and outcome of prcegnancies complicated with adnexal masses”. Arch. Gynecol. Obstet., 2003, 267, 148.

[14] Bakri Y.N., Ezzat A., Akhtar, Dohami, Zahrani: “Malignant germ cell tumors of the ovary pregnancy considerations”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2000, 90, 87.

[15] Han J.Y., Nava-Ocampo A.A., Kim T.J., Shim J.U., Parka C.T.: “Pregnancy outcome after prenatal exposure to bleomycin, etoposide and cisplatin for malignant ovarian germ cell tumors: report of 2 cases”. Reprod. Toxicol., 2005, 19, 557.

[16] Leiserowitz G.S., Xing G., Cress R., Brahmbhatt B., Dalrymple J.L., Smith L.H.: “Adnexal masses in pregnancy: how often are they malignant?”. Gynecol. Oncol., 2006, 101, 315.

[17] Zhao X.Y., Huang H.F., Lian L.J., Lang J.H.: “Ovarian cancer in pregnancy: a clinicopathologic analysis of 22 cases and review of the literature”. Int. J. Gynecol. Cancer, 2006, 16, 8.

[18] Norris H.J., Zirkin H.J., Benson W.L.: “Immature (malignant) teratoma of the ovary: A clinical and pathologic study of 58 cases”. Cancer, 1976, 37, 2359.

[19] American Joint Committee on Cancer: “Ovary”. In: AJCC Cancer Staging Manual, 6th edn., New York, Springer-Verlag, 2002, 275.

[20] Munnell E.W.: “Primary ovarian cancer associated with pregnancy”. Clin. Obstet. Gynecol., 1963, 30, 983.

[21] Roberts J.A.: “Management of gynecologic tumors during pregnancy”. Clin. Perinatol., 1983, 10, 369.

[22] Sivanesaratnam V.: “Gynaecological malignancies in pregnancy”. Rev. Gynaecol. Pract., 2004, 4, 162.

[23] Boulay R., Podczaski E.: “Ovarian cancer complicating pregnancy”. Obstet. Gynecol. Clin. N. Am., 1998, 25, 385.

[24] Daponte A., Stergioti E., Messinis I.E.: “Risk scoring for adnexal masses and endoscopic management”. Int. J. Gynecol. Obstet., 2007, 96, 42.

[25] Sherard G.B., Hodson C.A., Williams H.J., Semer D.A., Hadi H.A., Tait D.L.: “Adnexal masses and pregnancy: a 12-year experience”. Am. J. Obstet. Gynecol., 2003, 189, 358.

[26] Lee G.S., Hur S.Y., Shin J.C., Kim S.P., Kim S.J.: “Elective vs conservative management of ovarian tumors in pregnancy”. Int. J. Gynaecol. Obstet., 2004, 85, 250.

[27] Curry S.L., Smith J.P., Gallagher H.S.: “Malignant teratoma of the ovary: Prognostic factors and treatment”. Am. J. Obstet. Gynecol., 1978, 131, 845.

[28] Beiner M.E., Gotlieb W.H., Korach Y., Shrim A., Stockheim D., Segal Y. et al.: “Cystectomy for immature teratoma of the ovary”. Gynecol. Oncol., 2004, 93, 381.

[29] Thurlbeck W.M., Scully R.E.: “Solid teratoma of the ovary. A clinicopathological analysis of 9 cases”. Cancer, 1960, 13, 804.

[30] Gershenson D.M.: “Management of early ovarian cancer: germ cell and sex cordstromal tumors”. Gynecol. Oncol., 1994, 55 (3 Pt 2), S62.

[31] Kojs Z., Urbanski K., Mitus J., Reinfuss M., Pudelek J., Walasek T.: “Pure immature teratoma of the ovary: analysis of 22 cases”. Eur. J. Gynecol. Oncol., 1997, 18, 534.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top