Secondary involvement of breast with non-Hodgkin’s lymphoma in a patient with HIV infection - case report

Secondary lymphoma of the breast is a rare entity in patients with non-Hodgkin's lymphoma (NHL). HIV infection is associated with an increased risk for developing NHL, however lymphomatous involvement of the breast in AIDS patients has rarely been reported. We present the case of a 33-year-old HIV-infected female patient with diffuse NHL who presented with a unilateral breast mass. Histologic examination of the biopsy specimen revealed a highly-malignant diffuse large B-cell lymphoma.

Breast lymphoma; HIV; non-Hodgkin’s lymphoma

[1] Chanan-Khan A., Holkova B., Goldenberg A.S., Pavlick A., Demopoulos R., Takeshita K.: “Non-Hodgkin’s lymphoma presenting as a breast mass in patients with HIV infection: a report of three cases”. Leuk Lymphoma, 2005, 46, 1189.

[2] Freeman C., Berg J.W., Cutler S.J.: “Occurrence and prognosis of extranodal lymphomas”. Cancer, 1972, 29, 252.

[3] Kiresi D.A., Kivrak A.S., Ecirli S., Toy H.: “Secondary breast, pancreatic, and renal involvement with non-Hodgkin’s lymphoma: Imaging findings”. Breast, 2006, 15, 106.

[4] Soyupak S.K., Sire D., Inal M., Celiktas M., Akgul E.: “Secondary involvement of breast with non-Hodgkin’s lymphoma in a paediatric patient presenting as bilateral breast masses”. Eur. Radiol., 2000, 10, 519.

[5] Cohen P.L., Brooks J.J.: “Lymphomas of the breast: a clinicopathologic and immunohistochemical study of primary and secondary cases”. Cancer, 1991, 67, 1359.

[6] Pantanowitz L., Connolly J.L.: “Pathology of the breast associated with HIV/AIDS”. Breast. J., 2002, 8, 234.

[7] Demirkazık F.B.: “MR imaging features of breast lymphoma”. Eur. J. Radiol., 2002, 42, 62.

[8] Gallardo X., Sentis M., Castaner E., Andreu X., Darnell A., Canalias J.: “Primary lymphoma of the breast: MR imaging features. A case report”. Magn. Reson. Imaging, 1999, 17, 479.