Article Menu

Export Article

More by Authors Links

Article Data

  • Views 398
  • Dowloads 100

Case Reports

Open Access

Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report

  • A. Cetin1
  • Z. Bahat2,*,
  • P. Cikesiz1
  • N. Demirbag3
  • E. Yavuz4

1Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Turkey

2Department of Oncology, Haseki Education and Research Hospital, Turkey

3Department of Pathology, Haseki Education and Research, Turkey

4Department of Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey

DOI: 10.12892/ejgo200703241 Vol.28,Issue 3,May 2007 pp.241-244

Published: 10 May 2007

*Corresponding Author(s): Z. Bahat E-mail:

PDF (3.22 MB)

Abstract

Background: Alpha-fetoprotein (AFP) is a useful tumor marker for germ cell tumors of the ovary and is valuable for both diagnosis and follow-up. However, it is very rare for an epithelial ovarian carcinoma to secrete AFP.

Case: We report a case of a 63-year-old woman with a ovarian clear cell carcinoma with serous component of less than 10%. Both histological components were producing AFP as demonstrated by immunohistochemistry. After surgery and chemotherapy, AFP decreased to normal range. The patient also had elevated CA-125 levels but the tumor was negative for CA-125 which suggested the increased CA-125 might have been due to the associated ascites.

Conclusion: Ovarian clear cell type carcinomas rarely secrete only AFP and it might be the single marker that could be used in follow-up.

Keywords

Clear cell carcinoma; Serous adenocarcinoma; Epithelial ovarian carcinoma; Tumor marker; AFP; CA-125

Cite and Share

A. Cetin,Z. Bahat,P. Cikesiz,N. Demirbag,E. Yavuz. Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report. European Journal of Gynaecological Oncology. 2007. 28(3);241-244.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200703241

References

[1] Tsukamoto N., lmachi M., Uchino H., Ono M., Kamura T., Saito T., Matsukuma K.: "Modified VAB-3 combination chemoterapy of advanced and recurrent endodermal sinus tumors of ovary". Gynecol. Oncol., 1985, 20, 336.

[2] Matsuta M., Ishikura H., Murakami K., Kagabu T., Nishiya I "Hepatoid cancer of the ovary: a case report". Int. J. Gynecol Pathol., 1991, 10, 302.

[3] Konishi I., Fujii S., Kataoka N., Noda Y., Okamura H., Yarnabe H., et al.: "Ovarian mucinous cystadenocarcinorna producing alphafetoprotein". Int. J. Gynecol. Pathol.. I 988, 7I, 82.

[4] Maida Y., Kyo S., Ta灿kura M., Kanaya T., Inoue M.: "Ovanan endometrioid adenocarcinorna with ectopic production of alphafetoprotein". Gynecol. Oncol., 1998, 71, 133.

[5] Nogales FF., Bergeron C., Carvia R.E., Alvaro T., Fulwood H.R "Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm: Analysis of six cases". Am J. Surg. Pathol., 1996, 20, 1056.

[6] Ramalingam P., Malpica A., Silva E.G., Gershenson D.M., Liu J.L., Deavers M.T.: "The use of cytokeratin 7 and EMA in differentiating ovarian yolk sac tumors from endometrioid and clear cell carcinomas". Am. J. Surg. Pathol., 2004, 28, 1499.

[7] Clear Cell Adenocarcinoma World Health Organization Classificatioo of Tumours Pathology and Genetics/Tumours of Breast and Female Genital Organs. In: H.A. Tavassol and P. Device (eds.). International Agency for Research on Cancer (IARC) Lyon, France, 2003, 137.

[8] Topalak 0., Sayg山U., Soyturk M., Karaca N., BaturY., Uslu T. et al.: "Serum, pleural effusion, and ascites CA-125 levels in ov,trian cancer and nonovarian benign and malignant diseases: a comparative study". Gynecol. Oneal., 2002, 85, 108.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top