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5-Fluorouracil cardiotoxicity complicating treatment of Stage IIB cervical cancer - case report

  • J.P. GEISLER1,*,
  • K.J. Manahan1
  • J.K. Rippy2

1Indiana Women's Oncology, St. Vincent Hospitals, USA

2The Care Group, Division of Cardiology St. Vincent Hospitals, Indianapolis, IN, USA

DOI: 10.12892/ejgo200703235 Vol.28,Issue 3,May 2007 pp.235-235

Published: 10 May 2007

*Corresponding Author(s): J.P. GEISLER E-mail:

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Abstract

A 31-year-old female was found to have FIGO Stage IIB squamous cell carcinoma of the cervix. The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy. During the first day of infusion, she began having severe shortness of breath. Cardiac evaluation revealed acute congestive heart failure with a cardiac ejection fraction of 19%. Radiation was continued without chemotherapy. Four years later, the patient is alive and well with an ejection fraction of 53%.

Keywords

Cisplatin; 5-Fluorouracil cardiotoxicity; Cervical cancer

Cite and Share

J.P. GEISLER,K.J. Manahan,J.K. Rippy. 5-Fluorouracil cardiotoxicity complicating treatment of Stage IIB cervical cancer - case report. European Journal of Gynaecological Oncology. 2007. 28(3);235-235.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200703235

References

[1] Keys H.M., Bundy B.N., StehmanF.B., Muderspach L.I., Chafe W.E., Suggs III C.L. et al.: "Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky Stage 1B cervical carcinoma". N. Engl. J. Med., 1999, 340, 1154.

[2] Morris M., Eifel P., Lu J., Grigsby P.W., Levenback C., Stevens R.E. et al.: "Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer". N. Engl. J. Med., 1999, 340, 1137.

[3] Rose P.G., Bundy B.N., Watkins E.B., Thigpen J.T., Deppe G., Maiman M.A. et al.: "Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer". N. Engl. J. Med., 1999, 340, 1144.

[4] McG!inchey P.G., Webb S.T., Campbell N.P.: "5-fluorouracilinduced cardiotoxicity mimicking myocardial infarction: a case report". BMC Cardiovascular Disorders, 2001, 1, 3.

[5] Lanciano R., Calkins A., Bundy B.N., Parjham G., Lucci J.A. 3rd Moore D.H. et al.: "Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination in advanced cervix cancer: a gynecologic oncology group study". J. Clin. Oncol., 2005, 23, 8277.

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