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Cancer of the vulva in a 25-year-old woman with VIN III and high-grade cervical SIL - case report
1Department of Obstetrics and Gynecology, Spain
2Department of Pathology, Hospital Sant Joan de Deu,University of Barcelona, Barcelona, Spain
*Corresponding Author(s): E. Gonzalez-Bosquet E-mail:
Human papillomavirus (HPV) infection is associated with an increase in intraepithelial lesions of the genital tract which are often multicentric. Following is a presentation of a case of vulvar cancer in a young woman (25 years of age) with multiple vulvar intraepithelial neoplasia (VIN III) lesions, a high-grade squamous intraepithelial cervical lesion, and a HPV type 16 infection at high risk of oncogenic transformation. This case offers an opportunity to discuss the risk factors that may favor the appearance of these lesions in young women, and their clinical management, diagnosis, and treatment.
Vulvar cancer; YIN; High-grade SIL; HPV
E. Gonzalez-Bosquet,M. Sunol,A. Hernandez,J. Callejo,J.M. Lailla. Cancer of the vulva in a 25-year-old woman with VIN III and high-grade cervical SIL - case report. European Journal of Gynaecological Oncology. 2007. 28(2);131-133.
[1] Zarcone R., Mainin G., Carfora E., Cardone A.: "Current etiopathogenetic views in vulvar cancer". Panminerva Med., 1997, 39, 30.
[2] Al-Ghamdi A., Freedman D., Miller D., Poh C., Rosin M., Zhang L., Gilks C.B.: "Vulvar squamous cell carcinoma in young women: a clinicopathologic study of 21 cases". Gynecol. Oneal., 2002, 84, 94.
[3] Van Beurden M., ten Kate F.W., Tjong-A-Hung S.P., de Craen A.J., van der Vange N., Lammes F.B., ter Schegget J.: "Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia". lnt. J. Gynecol. Pathol., 1998, 17, 12.
[4] Sasco A.J., Gendre I.: "Current epidemiology of vulvar cancer" Contracept. Fertil. Sex, 1998, 26, 858.
[5] Monk BJ., Burger R.A., Lin F., Parham G., Vasilev S.A., Wilczynski S.P.: "Prognostic significance of human papillomavirus DNA in vulvar carcinoma". Obstet. Gynecol., 1995, 85, 709.
[6] Basta A., Adamek K., Pitynski K.: "lntraepithelial neoplasia and early stage vulvar cancer. Epidemiological, clinical and virological observations". Eur. J. Gynecol. Oneal., 1999, 20, 111.
[7] Lillo F.B.: "Human pap仆loma virus infection and its role in the genesis of dysplastic and neoplastic lesions of squamous epithelia". New Microbial., 2005, 28, 11.
[8] Basta A., Adamek K., Pawlak M:., Przeszlakowski D.: "Incidence of precancerous states and carcinomas of the vulva in young women". Prrzegl. Lek., 1999, 56, 20.
[9] Jones R.W.: "Vulvar intraepithelial neoplasia: current perspectives". Eur. J. Gynecol., 2001, 22, 393.
[10] Hillemanns P., Wang X.: "Integration of HPV-16 and HPV-18 DNA in vulvar intraepithelial neoplasia". Gynecol. Oneal., 2006, 100, 276.
[11] Van Beurden M., ten Kate F.J., Smitis H.L., Berkhout R.J., de Craen A.J., van derVange N., Lammes F.B., ter Schegget J.: "Muitifocal vulvar intraepithelial neoplasia grade III and multicentric lower gebital tract neoplasia in associated with transcriptional active human papilloma virus". Cancer, 1995, 75, 2879.
[12] Traiman P., Bacchi C.E., De Luca L.A., Uemura G., Nahas Neto J., Hahas E.A., Pontes: "Vulvar carcinoma in young patients and its relationship with genital warts". Eur. J. Gynecol. Oneal., 1999, 20, 191.
[13] Ait Menguellet S., Collinet P., Debarge V.H., Nayama M., Vinatier D., Leroy J.L.: "Management of multicentric lesions of the lower tract". Eur. J. Gynecol. Reprod. Biol., 2006, May 17 (Epub ahead of print).
[14] Hording U., Daugart S., Jumge J., Lunvall F.: "Human papilloma virus and multifocal neoplasia". Int. J. Gynecol. Pathol., 1996, 15, 230.
[15] McCartney A.J.: "Surgery of intraepithelial neoplasia, CIN, VaIN, and VIN". Baillieres Clin. Obstet. Gynecol., 1978, 1, 447.
[16] Ayhan A., Tuncer Z.S., Dogan L., Yuce K., Kucukali T.: "Skinnmg vulvectomy for the treatment of vulvar intraepithelial neoplasia 2-3: a study of 21 cases". Eur. J. Gynaecol. Oneal., 1998, 19, 508.
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