Immunoreactivities of human nonmetastatic clone 23 and p5 3 products are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients

Objective: To assess the relation between expressions of human nonmetastatic clone 23 (nm23-H1) and p53 in cervical cancer, their relationships with lymph node metastasis, and further to examine their predictive of lymph node metastases.

Materials and methods: nm23-H1 and p53 expression profiles were visualized by immunohistochemistry in early-stage cervical cancer specimens.

Results: Immunoreactivities of nm23-H1 and p53 were disassociated. The independent variables related with lymph node metastases were grade of cancer cell differentiation (p < 0.029) and stromal invasion (p < 0.039). Sensitivity, specificity, positive and negative predictive values, and accuracy for lymph node metastasis were calculated to be 91.7%, 13.5%, 25.6%, 83.3%, and 32.7% for nm23-H1 and 66.7%, 51.4%, 30.8%, 82.6%, and 55.1% for p53.

Conclusion: Nm23-H1 and p53 are disassociated and not good predictors of lymph node metastases in early-stage cervical cancer patients. However, stromal invasion and cell differentiation can predict lymph node metastasis.

Early-stage cervical cancer; Human nonmeta tatic clone 23; p53; Lymph node metastasis; Grade of cell differentiation; Stromal invasion

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