Article Data

  • Views 378
  • Dowloads 125

Reviews

Open Access

Molecular markers of miscellaneous primary and metastatic tumors of the uterine cervix S.

  • S.C. Chauhan1
  • D. Kumar2
  • M.C. Bell1
  • M.D. Koch3
  • M. Verma4,*,

1Cancer Biology Research Institute, South Dakota Health Research Foundation and Department of Obstetrics and Gynecology, USA

2Department of Biological and Environmental Sciences, University of the District of Columbia, Washington, USA

3Department of Laboratory Medicine, Sanford School of Medicine, the University of South Dakota, USA

4Analytic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA

DOI: 10.12892/ejgo20070105 Vol.28,Issue 1,January 2007 pp.5-14

Published: 10 January 2007

*Corresponding Author(s): M. Verma E-mail:

Abstract

Miscellaneous primary tumors of the uterine cervix are rare. Markers which can be utilized to detect these tumors are very few and in most cases, have not been clinically validated. The information provided in this article will help in developing strategies to discover novel markers and initiate translational research in this ignored area. Based on the reported studies, cytokeratin markers are common in many tumors and few of these rare cancers demonstrate human papilloma-virus (HPV) and Epstein Bar virus (EBY) infection. Due to the very low prevalence of these tumors, epidemiological studies have not been conducted and the etiology of these tumors is largely unknown.

Keywords

Uterine cervix; Rare tumors; Markers; Metastatic

Cite and Share

S.C. Chauhan,D. Kumar,M.C. Bell,M.D. Koch,M. Verma. Molecular markers of miscellaneous primary and metastatic tumors of the uterine cervix S.. European Journal of Gynaecological Oncology. 2007. 28(1);5-14.

References

[1] Culton L.K., Deavers M.T., Silva E.G., Liu J., Malpica A.: "Endometrioid carcinoma simultaneously involving the uterus and the fallopian tube: a clinicopathologic study of 13 cases". Am. J. Surg. Pathol., 2006, 30, 844.

[2] Fukunaga M., Fujiwara Y., Naito Z.: "Hepatoid carcinoma with serous component of the fallopian tube: a case report with immunohistochem­ical and ultrastructural studies". Int. J. Gynecol. Pathol., 2006, 25, 233

[3]Kirshtein B., Meirovitz M., Okon E., Piura B.: "Sister Mary Joseph's nodule as the first presenting sign of primary fallopian tube adenocarci 一 noma". J. Minim. Invasive Gynecol., 2006, 13, 234.

[4] Singha! P., Odunsi K., Rodabaugh K., Driscoll D., Lele S.: "Primary fallopian tube carcinoma: a retrospective clinicopathologic study". Eur. J. Gynaecol. Oneal., 2006, 27, 16.

[5] Kietpeerakool C., Suprasert P., Srisomboon J., Pantusart A.: "Primary carcinoma of the fallopian tube: A clinicopathologic analysis of 27 patients". J. Med. Assoc. Thai, 2005, 88, 1338

[6] Batra S., Singh M., Wynn J.S.: "An unusual case of primary fallopian tube carcinoma in pregnancy". Int. J. Gynecol. Cancer, 2006, 16 (suppl I), 365.

[7] Young R.H., Clement P.B.: "Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed". Semin. Diagn. Pathol., 1995, 12, 14.

[8] Toyoshima M., Okamura C., Niikura H., Ito K., Yaegashi N.: "Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature". Gynecol. Oneal., 2005, 97, 957.

[9]Brown J., Broaddus R., Koeller M., Burke T.W., Gershenson D.M., Bodurka D.C.: "Sarcomatoid carcinoma of the cervix". Gynecol. Oneal., 2003, 90, 23.

[IO]Lin C.P., Ho C.L., Shen M.R., Huang L.H., Chou C.Y.: "Evidence of human pap仆lomavirus infection, enhanced phosphorylation of retinoblas­ toma protein, and decreased apoptosis in sarcomatoid squamous cell carcinoma of uterine cervix". Int. J. Gynecol. Cancer,2006, 16, 336

[11] Baker A.C., Eltoum I., Curry R.O., Stockard C.R., Manne U., Grizzle W.E., Chhieng D.: "Mucinous expression in benign and neoplastic glan­dular lesions of the uterine cervix". Arch. Pathol. Lab. Med., 2006, 130, 1510

[12] Russell M.J., Fadare 0.: "Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts". Diagn. Pathol., 2006, I, 18.

[13] Teramoto N., N咖mura R., Saeki T., Nogawa T., Hiura M.: "Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma". Pathol. Int., 2005, 55, 445.

[14] Senzaki H., Osaki T., Uemura Y., Kiyozuka Y., Ogura E., Okamura A., Tsubura A.: "Adenoid basal carcinoma of the uterine cervix: 1mmuno­stochemical study and literature review". Jpn. J. Clin. Oneal., 1997, 27, 437.

[15] Grayson W., Taylor L.F., Cooper K.: "Adenoid basal carcinoma of the uterine cervix: detection of integrated human papillomavirus ma rare tumor of putative "reserve cell" origin". Int. J. Gynecol. Pathol., 1997, 16, 307.

[16] Baggish M.S., Woodruff J.D.: "Adenoid-basal carcinoma of the cervix". Ohstet. Gynecol., 1966, 28, 213.

[17] Brinck U., Jakob C., Bau 0., Fuzesi L.: "Papillary squamous cell carcinoma of the uterine cervix: report of three cases and a review of its clas­sification". Int. J. Gynecol. Pathol., 2000, 19, 231.

[18] Murata S., Miyata K., Takaishi K., Mochizuki K., Nakazawa T., Kondo T., Nakamura N., Katoh R.: "Mixed pap仆lary adenocarcinoma and tran­sitional cell carcinoma of the uterine cervix". Pathol. Int., 2004, 54, 63.

[19] Nishida M., Nasu K., Takai N., Miyakawa I., Kashima K.: "Adenoid cystic carcinoma of the uterine cervix". Int. J. Clin. Oneal., 2005, JO, 198.

[20] Albores-Saavedra J., Nadji M., Henson D.E.: "Intestinal-type adenocarcinoma of the gallbladder. A clinicopathologic study of seven cases". Am. J. Surg. Pathol., 1986, JO, 19.

[21] Albores-Saavedra J., Gersell D., Gilks C.B., Henson D.E., Lindberg G., Santiago H. et al.: "Terminology of endocrine tumors of the utenne cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute". Arch. Pathol. Lab. Med., 1997, 121, 34.

[22] Bocker W.: "WHO classification of breast tumors and tumors of the female genital organs: pathology and genetics". Verh. Dtsch. Ges. Pathol., 2002, 86, 116.

[23] Giordano G., D'Adda T., Gnetti L., Froio E., Merisio C., Melpignano M.: "Detection of human papillomavirus in organs of upper genital tract in women with cervical cancer". Int. J. Gynecol. Cancer, 2006, 16, 1601.

[24] Kawauchi S., Okuda S., Morioka H., Iwasaki F., Fukuma F., Chochi Y., Furuya T., Oga A., Sasaki K.: "Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study". Hum. Pathol., 2005, 36, 1096.

[25] Tangjitgamol S., Ramirez P.T., Sun C.C., See H.T., Jhingran A., Kavanagh J.J., Deavers M.T.: "Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic and prognostic study". Int. J. Gynecol. Cancer, 2005, I 5, 646.

[26] Grayson W., Rhemtula H.A., Taylor L.F., Allard U., Tiltman A.J.: "Detection of human papillomavirus in large cell neuroendocrine carcinoma of the uterine cervix: a study of 12 cases". J. Clin. Pathol., 2002, 55, 108.

[27] Ishida G.M., Kato N., Hayasaka T., Saito M., Kobayashi H., Katayama Y. et al.: "Small cell neuroendocrine carcinomas of the uterine cervix. a histological, immunohistochemical, and molecular genetic study". Int. J. Gynecol. Pathol., 2004, 23, 366.

[28] Ishida T., Yano T., Sugimachi K.: "Clinical applications of the pathological properties of small cell carcinoma, large cell carcinoma, and adenoid cystic carcinoma of the lung". Semin. Surg. Oneal., 1990, 6, 53.

[29] Ishida T., Nishino T., Oka T., Yasumoto K., Sugimachi K., Hara N., Ohta M.: "Surgical treatment of patients with small cell carcinoma of the lung: a histochemical and immunohistochemical study". J. Surg. Oneal., 1989, 40, 188.

[30] Tsunoda S., Jobo T., Arai M., Imai M., Kanai T., Tamura T. et al.: "Small-cell carcinoma of the uterine cervix: a clinicopathologic study of 11 cases". Int. J. Gynecol. Cancer, 2005, 15, 295.

[31] Young R.H., Harris N.L., Scully R.E.: "Lymphoma-like lesions of the lower female genital tract: a report of 16 cases". Int. J. Gynecol. Pathol., 1985, 4, 289.

[32] Piura B., Yanai-Inbar I., Rabinovich A., Meirovitz M.: "Lymphoma-like lesion of the uterine cervix". Eur. J. Obstet. Gynecol. Reprod. Biol., 2001, 97, 235.

[33] Hachisuga T., Ookuma Y., Fukuda K., lwasaka T., Sugimori H., Watanabe T.: "Detection of epstein-barr virus DNA from a lymphoma-like lesion of the uterine cervix". Gynecol. Oneal., 1992, 46, 69.

[34] Nasu K., Yoshimatsu J., Urata K., Miyakawa I.: "A case of primary non-Hodgkin's lymphoma of the uterine cervix treated by combination chemotherapy (THP-COP)". J. Ohstet. Gynaecol. Res., 1998, 24, 157.

[35] Venizelos I.D., Zafrakas M., Dragoumis K., Mandala E., Bondis J.: "Non-Hodgkin's lymphoma involving the uterine cervix after treatment for Hodgkin disease". Leuk. Lymphoma, 2003, 44, 2155.

[36] Szantho A., Balega J.J., Csapo Z., Sreter L.L., Matolcsy A., Papp Z.: "Primary non-Hodgkin's lymphoma of the uterine cervix successfully treated by neoadjuvant chemotherapy: case report". Gynecol. Oneal., 2003, 89, 171.

[37] Garavaglia E., Taccagni G., Montoli S., Panacci N., Ponzoni M., Frigerio L., Mang山G.: "Primary Stage I-IIE non-Hodgkin's lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients". Gynecol. Oneal., 2005, 97, 214.

[38] Yokoyama Y., Sato S., Xiao Y.H., Tanaka K., Maruyama H., Saito Y.: "Primary non-Hodgkin's lymphoma of the uterine cervix". Arch. Gynecol Obstet., 2001, 265, 108.

[39] Vang R., Medeiros L.J., Ha C.S., Deavers M.: "Non-Hodgkin's lymphomas involving the uterus: a clinicopathologic analysis of 26 cases". Mod Pathol., 2000, 13, 19.

[40] Cid J.M.: "Melanoid pigmentation of the endocervix: a neurogenic visceral argument". Ann. Anat. Pathol. (Paris), 1959, 4, 617.

[41] Cantuaria G., Angioli R., Fernandez-Abril A., Penalver M.: "Primary malignant melanoma of the uterine cervix: case report and review of the literature". Prim. Care Update Ob/Gyns, 1998, 5, 159.

[42] Cantuaria G., Angioli R., Nahmias J., Estape R., Penalver M.: "Primary malignant melanoma of the uterine cervix: case report and review of the literature". Gynecol. Oneal., 1999, 75, 170.

[43] Iida T., Yasuda M., Kajiwara H., Minematsu T., Osamura R.Y., ltoh J., Inomo A., Hirasawa T Os Muramatsu T., Murakami M.: "Case of utenne cervical carcinosarcoma". J. Obstet. Gynaecol. Res., 2005, 31, 404

[44] Takeshima Y., Amatya V.J., Nakayori F., Nakano T., Iwaoki Y., Daitoku K., Inai K.: "C o-existent carcinosarcoma and adenoid basal carcinoma of the uterine cervix and correlation with human papillomavirus infection". Int. J. Gynecol. Pathol., 2002, 21, 186.

[45] Depond W.D., Flauta V.S., Lingamfelter D.C., Schnee D.M., Menendez K.P.: "Adenoid basal carcinoma of the cervix in a 20-year-old female a case report". Diagn. Pathol., 2006, 1, 20

[46] Parwani A.V., Smith Sehdev A.E., Kurman R.J., Ronnett B.M.: "Cervical adenoid basal tumors comprised of adenoid basal epitheltoma asso­ciated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and p16expression". Hum Pathol., 2005, 36, 82.

[47] Hiroi M., Fukunaga T., Miyazaki E., Hayashi Y., Kuroda N., Toi M. et al.: "Adenoid basal carcinoma of the uterine cervix: a case report with ultrastructural findings". Med. Electron Microsc., 2000, 33, 241.

[48] Brainard J.A., Hart W.R.: "Adenoid basal epitheliomas of the uterine cervix: a reevaluation of distinctive cervical basaloid lesions currently classified as adenoid basal carcinoma and adenoid basal hyperplasia". Am. J. Surg. Pathol., 1998, 22, 965.

[49] Ordi J., Romagosa C., Tavassoli F.A., Nogales F., Palacin A., Condom E. et al.: "CDlO expression in epithelial tissues and tumors of the gyne­cologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors". Am. J. Surg. Pathol., 2003, 27, 178.

[50] Fadare 0.: "Uncommon sarcomas of the uterine cervix: a review of selected entities". Diagn. Pathol., 2006, 1, 30.

[51] Snijders-Keilholz A., Ewing P., Seynaeve C., Burger C.W.: "Prim山ve neuroectodermal tumor of the cervix uteri: a case report - changing con­cepts iu therapy". Gynecol. Oncol., 2005, 98, 516.

[52] Ward B.S., Hitchcock C.L., Keyhani S.: "Primitive neuroectodermal tumor of the uterus. A case report". Acta Cytol., 2000, 44, 667.

[53] Daya D.A., Scully R.E.: "Sarcoma botryoides of the uterine cervix in young women: a clinicopathological study of 13 cases". Gynecol. Oncol., 1988, 29, 290.

[54] Semczuk A., Baranowski W., Berbec H., Marzec B., Skomra D., Miturski R.: "Analysis of p53 and K-ras genes and their proteins ma sarcoma botryoides of the uterine cervix". Eur. J. Gynaecol. Oneal., 1999, 20, 311.

[55] Ramos P., Ruiz A., Carabias E., Pinero I., Garzon A., Alvarez I.: "Mullerian adenosarcoma of the cervix with heterologous elements: report of a case and review of the literature". Gynecol. Oneal., 2002, 84, 16 I.

[56] Bell D.A., Shimm D.S., Gang D.L.: "Wilms' tumor of the endocervix". Arch. Pathol. Lab. Med., 1985, 109, 371.

[57] Di Giovannantonio L., Bellocci R., Zappacosta R., Zappacosta B., Castrataro A., Liberatore M. et al.: "Primary malignant schwannoma of the uterine cervix: a malignant tumor with unusual behaviour. A case report". Pathologica, 2005, 97, 7.

[58] Nguyen C.T., Tan J., Blackwell K.E., Bhuta S., Sercarz J.: "A. Primary melanocytic schwannoma of cervical sympathetic chain". Head Neck, 2000, 22, 195.

[59] Lallas T.A., Mehaffey P.C., Lager D.J., Van Voorhis B.J., Sorosky J.I.: "Malignant cervical schwannoma: An unusual pelvic tumor". Gynecol Oneal., 1999, 72, 238.

[60] Keel S.B., Clement P.B., Prat J., Young R.H.: "Malignant schwannoma of the uterine cervix: a study of three cases". Int. J. Gynecol. Pathol., I 998, /7, 223.

[61] Junge J., Horn T., Bock J.: "Primary malignant Schwannoma of the uterine cervix. Case report". Br. J. Obstet. Gynaecol., 1989, 96, 111.

[62] Kato N., Katayama Y., Kaimori M., Motoyama T.: "Glassy cell carcinoma of the uterine cervix: histochemical, immunohistochemical, and mo!­ecular genetic observations". Int. J. Gynecol. Pathol., 2002, 21, 134.

[63] Kuroda H., Toyozumi Y., Masuda T., Ougida T., Hanami K., Kyoko K. et al.: "Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein". Acta Cytol., 2006, 50, 418.

[64] Al-Nafussi A.I., Al-Yusif R.: "Papillary squamotransitional cell carcinoma of the uterine cervix: an advanced stage disease despite superficial location: report of two cases and review of the literature". Eur. J. Gynaecol. Oneal., 1998, 19, 455.

[65] Barrett R.J. 2"", Davos I., Leuchter R.S., Lagasse L.D.: "Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix". Cancer, 1987, 60, 2325.

[66] Dilek T.U., Akcin U., Erdem 0., Tiras B., Dursun A.: "Uterine lipoma and coincidental cervical cancer: a case report". Int. J. Gynecol. Cancer, 2006, 16, 445.

[67] Nakao Y., Yokoyama M., Yasunaga M., Hara K., Nakahashi H., Iwasaka T.: "Metastatic tumor extending through the inferior vena cava into the right atrium: a case report of carcinoma of the uterine cervix with para-aortic lymph node metastases". Int. J. Gynecol. Cancer, 2006, /6, 914.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top