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Stage lb cervical cancer during pregnancy: planned delay in treatment - case report

  • K. Traen1,*,
  • D. Svane1
  • N. Kryger-Baggesen1
  • K. Bertelsen2
  • O. Mogensen1

1Department of Gynaecologic Oncology, Denmark

2Department of Oncology, Odense University Hospital, Odense, Denmark

DOI: 10.12892/ejgo200606615 Vol.27,Issue 6,November 2006 pp.615-617

Published: 10 November 2006

*Corresponding Author(s): K. Traen E-mail:

Abstract

Approximately 0.05% of pregnancies are complicated with cervical cancer. Treatment of this malignancy during pregnancy depends on the stage of disease and gestational age at the time of diagnosis. In women with Stage IB cervical cancer immediate treatment, without regard to the pregnancy, is traditionally advocated in the first and second trimester. A planned delay of treatment, to achieve foetal maturity, may be acceptable if there are no adverse maternal and foetal consequences. We present a case of a Stage IB1 cervical cancer, diagnosed during a twin pregnancy, and treated with a planned delay of 19 weeks. We have reviewed the literature and focused on what is known about planned delay in therapy of Stage IB cervical cancer, diagnosed before 30 weeks of gestational age.

Keywords

Cervical cancer; Pregnancy; Treatment delay

Cite and Share

K. Traen,D. Svane,N. Kryger-Baggesen,K. Bertelsen,O. Mogensen. Stage lb cervical cancer during pregnancy: planned delay in treatment - case report. European Journal of Gynaecological Oncology. 2006. 27(6);615-617.

References

[1] Hacker N.E, Berek J.S,, Lagasse LD., Charles E.H., Savage E.W., Moore J,G,: "Carcinoma of the cervix associated with pregnancy". Obstet GynecoL, 1982, 59, 735.

[2] Zemlickis D., Lishner M,, Degendorfer P., Panzarella T, Sutcliffe S.B., Koren G.: "Maternal and fetal outcome after invasive cervical cancer in pregnancy". J. Clin, Oneal.. 1991, 9, 1956.

[3] Hopkins M.P, Morley G,W,:'The prognosis and management of cervical cancer associated with pregnancy", Obstet. Gynecol., 1992, 80, 9.

[4] van der Vange N,, Weverling GJ,, Ketting B.W,, Ankum WM,, Samlal R., Lammes FB.: "The prognosis of cervical cancer associated with pregnancy: a matched cohort study", Obstet, Gynecol., 1995, 85, 1022.

[5] Van Calsteren K., Amant F, Vergote L: "Cervical neoplasia dunng pregnancy: diagnosis, management and prognosis", Best, Pract Res, Clin. Obstet, Gynaecol., 2005, 19, 611.

[6] Landoni F, Maneo A., Colombo A., Placa F, Milani R., Perego P. et al.: "Randomised study of radical surgery versus radiotherapy for Stage lb-Ila cervical cancer", Lancet, 1997, 23, 535.

[7] Rose P.G., Bundy B.N., Watkins E.B., Thigpen J.T., Deppe G., Maiman M.A. et al.: "Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer". N. Engl. J Med., 1999, 15, 1144.

[8] Norstrom A., Jansson I., Andersson H.: "Carcinoma of the uterine cervix in pregnancy". Acta Obstet. Gynecol Scan., 1997, 76, 583.

[9] Tewari K., Cappuccini F., Gambino A., Kohler M.F., Pecorelli S., DiSaia P.J.: "Neoadjuvant chemotherapy in the treatment of locally advanced cervical carcinoma during pregnancy: a report of two cases and review of issues specific to the management of cervical carcinoma in pregnancy including planned delay of therapy" Cancer, 1998, 15, 1529.

[10] Marana H.R., de Andrade J.M., da Silva Mathes A.C., Duarte G., da Cunha S.P.,Bighetti S.: "Chemotherapy in the treatment of locally advanced cervical cancer and pregnancy". Gynecol Oncol., 2001, 80, 272.

[11] Nisker J.A., Shubat M.: "Stage 1B cervical carcinoma and pregnancy: report of 49 cases". Am. J. Obstet. Gynecol., 1983, 15, 203.

[12] Greer B.E., Easterling T.R., McLennan D.A., Benedetti T.J., Cain J.M., Figge D.C. et al.: "Fetal and maternal considerations in the management of Stage 1-B cervical cancer during pregnancy". Gynecol. Oneal., 1989, 34, 61.

[13] Monk B.J., Montz F.J.: "Invasive cervical cancer complicating intrauterine pregnancy: treatment with radical hysterectomy" Obstet. Gynecol., 1992, 80, 199.

[14] Duggan B., Muderspach L.I., Roman L.D., Curtin J.P., d'Ablamg G. 3'', Morrow C.P.: "Cervical cancer in pregnancy: reporting on planned delay in therapy". Obstet. Gynecol., 1993, 82, 598.

[15] Allen D.G., Planner R.S., Tang P.T., Scurry J.P., Weerasiri T "Invasive cervical cancer in pregnancy". Aust N.Z.J. Obstet Gynaecol., 1995, 35, 408.

[16] Sorosky J.I., Squatrito R., Ndubisi B.U., Anderson B., Podczaski E.S., Mayr N. et al.: "Stage I squamous cell cervical carcinoma in pregnancy: planned delay in therapy awaiting fetal maturity" Gynecol. Oneal., 1995, 59, 207.

[17] Sood A.K., Sorosky J.I., Krogman S., Anderson B., Benda J., Buller R.E.: "Surgical management of cervical cancer complicating pregnancy: a case-control study". Gynecol. Oncol., 1996, 63, 294.

[18] Zanetta G., Pellegrino A., Vanzulli A., Di Leilo A., Milani R., Mangioni C.: "Magnetic resonance imaging of cervical cancer in pregnancy". Int. J. Gynecol. Cancer, 1998, 8, 265.

[19] van Vliet W., van Loon A.J., ten Hoor K.A., Boonstra H.: "Cerv1-cal carcinoma during pregnancy: outcome of planned delay in treatment". Eur. J Obstet. Gynecol. Reprod. Biol., 1998, 79, 153.

[20] Takushi M., Moromizato H., Sakumoto K., Kanazawa K.: "Management of invasive carcinoma of the uterine cervix associated with pregnancy: outcome of intentional delay in treatment" Gynecol. Oneal., 2002, 87, 185.

[21] Germann N., Haie-Meder C., Morice P., Lhomme C., Duvillard P., Hacene K. et al.: "Management and clinical outcomes of pregnant patients with invasive cervical cancer". Ann. Oneal., 2005, 16, 397.

[22] Stan C., Megevand E., Irion 0., Wang C., Bruchim I., Petignat P "Cervical cancer in pregnant women: laparoscopic evaluation before delaying treatment". Eur. J. Gynaecol. Oneal., 2005, 649.

[23] Bipat S., Glas A.S., van der Velden J., Zwinderman A.H., Bossuyt P.M., Stoker J.: "Computed tomography and magnetic resonance imaging in staging uterine cervical carcinoma: a systematic review". Gynecol. Oncol., 2003, 91, 59.

[24] Hricak H., Gatsonis C., Chi D.S., Amendola M.A., Brandt K., Schwartz L.H. et al.: "American College of Radiology Imaging Network 6651; Gynecologic Oncology Group 183. Role of imaging in pretreatment evaluation of early invasive cervical cancer: results of the intergroup study American College of Radiology Imaging Network 6651 - Gynecologic Oncology Group 183". J Clin Oncol., 2005, 20, 9329.

[25] Hertel H., Possover M., Kuhne-Heid R., Schneider A.: "Laparo scoopic lymph node staging of cervical cancer in the 19th week of pregnancy. A case report". Surg. Endosc., 2001, 15, 324.

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