Article Menu

Export Article

More by Authors Links

Article Data

  • Views 377
  • Dowloads 126

Case Reports

Open Access

Gorlin syndrome associated with basal cell carcinoma of the vulva: A case report

  • M. Giuliani1,*,
  • L. Di Stefano1
  • G. Zoccali1
  • E. Angelone1
  • P. Leocata2
  • G. Mascaretti1

1Department of Surgical Science, Italy

2Department of Anatomopathology, University of L'Aquila, Italy

DOI: 10.12892/ejgo200605519 Vol.27,Issue 5,September 2006 pp.519-522

Published: 10 September 2006

*Corresponding Author(s): M. Giuliani E-mail:

PDF (3.2 MB)

Abstract

Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a hereditary condition transmitted as an autosomal dominant trait with high penetrance and variable expressivity. The syndrome is characterized by numerous manifestations: basal cell carcinomas (BCCs) and odontogenic keratocysts (OKCs) are the leading ones. In this article a typical Gorlin syndrome case associated with basal cell carcinoma of the vulva is described.


Keywords

Gorlin syndrome; NBCCS; PTCH gene; Basal cell carcinoma; Odontogenic keratocyst; Carcinoma of the vulva; Lymphadenectomy


Cite and Share

M. Giuliani,L. Di Stefano,G. Zoccali,E. Angelone,P. Leocata,G. Mascaretti. Gorlin syndrome associated with basal cell carcinoma of the vulva: A case report. European Journal of Gynaecological Oncology. 2006. 27(5);519-522.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200605519

References

[1] Diaz-Fernandez J.M., Infante-Cossio P.. Belmonte-Caro R., RuizLaza L.. Garcia-Perla-Garcia A., Gutierrez-Perez J.L.: "Basal cell nevus syndrome. Presentation of six cases and literature review". Med. Oral. Patol. Oral. Cir. Bucal., 2005, 10 (suppl. 1), E57.

[2] Gorlin R.J.: "Nevoid basal-cell carcinoma syndrome". Dermatol Clin., 1995, 13, 113.

[3] Holikova Z., Massi D., Lotti T., Hercogova J.: "Insight into the pathogenesis of sporadic basal cell carcinoma". Int..T. Dermatol., 2004, 43, 865.

[4] Allen E.B., Kuan-Ping Y.:'The hedgehog pathway and basal cell carcinomas". Hum. Mot. Gen., 2001, 10, 757.

[5] Grosjean L.D.. Privat S.C.: "Sonic hedgehog signalling in basal cell carcinomas". Cancer Lett., 225 (2205), 181.

[6] Minami M. et al.: "Germline mutation of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome"..T. Dermatol. Sci., 2001, 27, 21.

[7] Manfredi M., Vescovi P., Bonannni M., Porter S.: "Nevoid basal cell carcinoma syndrome: a review of the literature". Int. J. Oral. Maxillofac. Surg., 2004, 33, 117.

[8] Lo Muzio L., Nocini P.F., Savoia A., Consolo U., Procaccini L., Zelante L., et al.: "Nevoid basal cell carcinoma syndrome. Clinical findings in 37 Italian affected individuals". Clin. Genet., 1999, 55, 34.

[9] Lo Muzio L., Nocini P.F., Bucci P., Pannone G.. Cousolo U., Procaccino M.: "Early diagnosis of nevoid basal cell carcinoma syndrome". J. Am. Dent. Assoc., 1999, 130, 669.

[10] Cohen M.M. Jr.: "Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses". Int. J. Oral. Ma.xilleofac. Surg., 1999, 28, 216.

[11] Evans D.G. et al.: "Complications of the nevoid basal cell carcinoma syndrome: results of a population based study". J. Med Genet., 1993, 30, 460.

[12] de Giorgi Y., Salvini C., Massi D., Raspollini M.R., Carli P "Yul var basal cell carcinoma: retrospective study and review of literature". Gynecol. Oncol., 2005, 97, 192.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top