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Is dosage of hormone replacement therapy related with endometrial polyp formation?

  • G. latrakis1
  • S. Zervoudis1
  • E. Antoniou1,*,
  • C. Tsionis2
  • A. Pavlou1
  • G. Kourounis4
  • K. Siskos3

1Technological Educational Institution of Athens, Greece

2Department of Obstetrics and Gynaecology,'Elena Benizelou'Hospital, Athens, Greece

3Department of Obstetrics and Gynaecology, University of Athens,'Alexandras'Hospital, Athens, Greece

4Department of Obstetrics and Gynaecology, University of Patras, Patras, Greece

DOI: 10.12892/ejgo200604393 Vol.27,Issue 4,July 2006 pp.393-394

Published: 10 July 2006

*Corresponding Author(s): E. Antoniou E-mail:

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Abstract

Purpose of investigation: To evaluate the effect of different doses of hormone replacement therapy (HRT) on endometrial polyp formation.

Methods: 398 menopausal women were initially evaluated through transvaginal ultrasound and patients who already had endometrial polyps were excluded from the study. One hundred and six (26.6%) eligible patients were enrolled and randomized into two groups of 53 patients to receive two different doses of HRT.

Results: Six patients with endometrial polyps were detected in the first group and one patient in the second one (p = 0.0502 for total chi-square and p = .1172 for chi-square with continuity correction) after a mean duration of treatment of 26 months and 28,5 months, respectively. There was no difference in the mean number or the mean volume of the polyps between the two subgroups with positive results.

Conclusion: Our study showed that endometrial polyp formation may be related with HRT dosage.

Keywords

Hormone replacement therapy (HRT); Endometrial polyp; Menopausal women

Cite and Share

G. latrakis,S. Zervoudis,E. Antoniou,C. Tsionis,A. Pavlou,G. Kourounis,K. Siskos. Is dosage of hormone replacement therapy related with endometrial polyp formation? . European Journal of Gynaecological Oncology. 2006. 27(4);393-394.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200604393

References

[1] Memarzadeh S., Broder M.S., Wexler A.S., Pernoll M.L.: "Bemgn disorders of the uterine corpus". In: DeCherney A.H., Nathan L. (eds.). Current Obstetrics & Gynecologic Diagnosis & Treatment New York, Lange Medical Books/McGraw-Hill, 2003.

[2] Oats J., Abraham S.: "Benign tumours, cysts and malformations of the genital tract". In: Llwellyn-Jones (ed.). Fundamentals of Obstetrics and Gynaecology. Edinburgh, Elsevier Mosby, 2005.

[3] Chou B., Vlahos N.: "Abnormal uterine bleeding". In: Bandowski B.J., Hearne A.E., Lambrou N.C., Fox H.E., Wallach E.E. (eds.) T he Johns Hopkins Manual of Gynecology and Obstetrics Philadelphia, Lippincott Williams & Wilkins, 2002.

[4] Munro M.G., Brill A.I.: "Gynecologic endoscopy". In: Berek J.S Novak's Gynecology. Philadelphia, Lippincott Williams & Wilkins, 2002.

[5] Jones N.L., Judd H.L.: "Menopause & postmenopause". In: DeCherney A.H., Nathan L. (eds.). Current Obstetrics & Gynecologic Diagnosis & Treatment. New York, Lange Medical Books/McGrawHill, 2003.

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