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Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case report

P. Klaritsch¹
O. Reich^1,*,
S. Regauer²
T. Bauernhofer³

¹Departments of Obstetrics and Gynecology, Medical University of Graz, Austria

²Departments of Pathology, Medical University of Graz, Austria

³Departments of Medical Oncology, Medical University of Graz, Austria

DOI: 10.12892/ejgo200603297 Vol.27,Issue 3,May 2006 pp.297-298

Published: 10 May 2006

*Corresponding Author(s): O. Reich E-mail:

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Abstract

Introduction: The efficacy of high-dose chemotherapy plus transplantation of autologous hematopoetic stem cells in patients with endometrial stromal sarcomas is unknown.

Case report: A 39-year-old woman with Stage III endometrial stromal sarcoma (ESS) underwent radical surgery, followed by five courses of ifosfamide, adriamycin and dacarbazine postoperatively. Six months after primary surgery stem cell priming was performed. Five months later bone marrow was aspirated and high-dose chemotherapy with carboplatin, vepeside and holoxan were administered after which bone marrow was retransfused. Seven years after primary surgery the patient developed an abdominal recurrence which was removed surgically and adjuvant radiotherapy was administered. One year later the patient underwent hemicolectomy because of a new recurrence infiltrating the ascending colon. Treatment with 25 mg exemestane was begun. The patient is currently alive and free of disease nine years after the initial diagnosis.

Conclusion: Aggressive chemotherapy with autologous stem-cell support seems to be ineffective in patients with ESS.

Keywords

Endometrial stromal sarcoma; Treatment; High-dose chemotherapy; Stem-cell support

Cite and Share

P. Klaritsch,O. Reich,S. Regauer,T. Bauernhofer. Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case report . European Journal of Gynaecological Oncology. 2006. 27(3);297-298.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200603297

References

[1] Gadducci A., Sartori E., Landoni F., Zola P., Maggino T., Urgesi A. et al.: "Endometrial stromal sarcoma: Analysis of treatment failures and survival". Gynecol. Oneal., 1996, 63, 247.

[2] Piver M.S., Rutledge F.N., Copeland L., Webster K., Blumenson L., Suh O.: "Uterine endolymphatic stromal myosis: a collaborative study". Obstet. Gynecol., 1984, 64, 173.

[3] Berchuck A., Rubin S.C., Hoskins W.J., Saigo P.E., Pierce V.K., Lewis J.L. Jr.: "T reatment of endometrial stromal tumors". Gynecol. Oneal., 1990, 36, 60.

[4] Sutton G., Blessing J.A., Park R., DiSaia P.J., Rosenshein N.: "Ifosfamide treatment of recurrent or metastatic endometrial stromal sarcomas previously unexposed to chemotherapy: a study of the Gynecologic Oncology Group". Obstet. Gynecol., 1996, 87, 747.

[5] El Husseiny G., Al Bareedy N., Mourad W.A., Mohamed G., Shoukri M., Subhi J., Ezzat A.: "Prognostic factors and treatment modalities in uterine sarcoma". Am. J. Clin. Oneal., 2002, 25, 256.

[6] Lehmer L.M., Miles P.A., Enck R.E.: "Complete remission of widely metastatic endometrial stromal sarcoma following combination chemotherapy". Cancer, 1979, 43, 1189.

[7] Reich O., Regauer S.: "Aromatase expression in low-grade endometrial stromal sacromas: an immunohistochemical study". Mod. Path., 2004, 17, 104.

[8] Reich O., Regauer S.: "Gonadotropin-releasing hormone receptor expression in endometrial stromal sarcomas: an immunohistochemical study". Mod. Path., 2005, 18, 573.

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