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Endometrial carcinosarcoma with osteoclast-like giant cells

  • F. Amant1,*,
  • I. Varidenput1
  • T. Van Gorp1
  • I. Vergote1
  • Ph. Moerman2

1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Belgium

2Department of Pathology, Catholic University of Leuven, Leuven, Belgium

DOI: 10.12892/ejgo20060192 Vol.27,Issue 1,January 2006 pp.92-94

Published: 10 January 2006

*Corresponding Author(s): F. Amant E-mail:

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Abstract

We encountered a case of endometrial cancer with a poorly differentiated epithelial component, accompanied by a compact proliferation of atypical spindle cells and osteoclast-like giant cells. Immunohistochemically, the epithelial component was EMA and prekeratin positive with vimentin-positive spindle cells, whereas the osteoclast-like giant cells were strongly immunoreactive for CD68. The description of osteoclast-like giant cells adds to the knowledge of endometrial carcinosarcoma tumor biology.

Keywords

Endometrium; Carcinosarcoma; Osteoclast-like giant cells

Cite and Share

F. Amant,I. Varidenput,T. Van Gorp,I. Vergote,Ph. Moerman. Endometrial carcinosarcoma with osteoclast-like giant cells. European Journal of Gynaecological Oncology. 2006. 27(1);92-94.

URL:

https://www.ejgo.net/articles/10.12892/ejgo20060192

References

[1] Clement Ph., Scully R.: "Tumors with mixed epithelial and mesenchymal elements". In: Clement Ph., Young R. (eds.). Tumors and Tumorlike Lesions of the Uterine Corpus and Cervix. Churchill Livingstone, New York, 1993, 329.

[2] Amant F., Moerman P., Davel G.H., De Vos R., Vergote I., Lindeque B.G. et al.: "Uterine carcinosarcoma with melanocytic differentiation". Int. J. Gynecol. Pathol., 2001, 20, 186.

[3] Sakai Y., Kupelioglu A.A., Yanagisawa A., Yamaguchi K., Hidaka E., Matsuya S. et al.: "Origin of giant cells in Osteoclast-like giant cell tumors of the pancreas". Hum. Pathol., 2000, 31, 1223.

[4] Sakai Y., Kupelioglu A., Yanagisawa et al.: "Origin of giant cells in osteoclast-like giant cell tumors of the pancreas". Hum. Pathol., 2000, 31, 1223.

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