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Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder

  • O. Triolo1,*,
  • F. Antico1
  • A. Mancuso1
  • V. Salimbeni1
  • P.A. Nicotina1

1Department of Gynecological, Obstetrical Sciences and Reproductive Medicine Department of Human Pathology University Hospital "G. Martino", Messina, Italy

DOI: 10.12892/ejgo200505543 Vol.26,Issue 5,September 2005 pp.543-544

Published: 10 September 2005

*Corresponding Author(s): O. Triolo E-mail:

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Abstract

Vaginal submucosal nodules were observed in a 67-year-old woman, with ultrasonographic features of an advanced uterine neoplasm. On biopsy, light microscopy suggested that the lesions might be metastatic foci from an extragenital cancer, with a prevalent tubular growth pattern. Parallel immunohistochemical reactions revealed a diffuse, strong CA 19-9 positivity in both the cell membrane and cytoplasm. Subsequently, high serum levels of such tumor marker were also found, and an extragenital cancer was suspected of pancreatic or biliary origin. A mass in the gallbladder fossa was then detected by computed tomography and a primary gallbladder adenocarcinoma was confirmed on ultrasound-guided biopsy.

Keywords

Vaginal metastatic cancer; Gallbladder adenocarcinoma; Gallbladder genital metastases; CA 19-9-expressing neoplasm

Cite and Share

O. Triolo,F. Antico,A. Mancuso,V. Salimbeni,P.A. Nicotina. Postmenopausal bleeding and vaginal nodules as the first presenting sign of adenocarcinoma of the gallbladder. European Journal of Gynaecological Oncology. 2005. 26(5);543-544.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200505543

References

[1] Schust D.J., Moore D.H., Baird D.B., Novotny D.B.: "Primary adenocarcinoma of the gallbladder presenting as primary gynecologic malignancy: a re-port of two cases". Obstet. Gynecol., 1994, 83, 831.

[2] Young R.H., Scully R.E.: "Metastatic tumors of the ovary". In Kurman R.J. (ed.) Blaustein's Pathology of the Female Genital Tract, New York, Springer-Verlag, 1063, 2002.

[3] Ono T., Komatsu M., Hoshino T., Ishii T., Fujii T., Oshima S. et al.: "Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9-producing gallbladder cancer" J. Gastroenterol., 1996, 31, 742.

[4] Kijima H., Kashiwagi H., Dowaki S., Ohtani Y., Tobita K., Matsubayasi H. et al.: "Stromal sialyl Le(a) expression is correlated with vascular invasion of human gallbladder adenocarcinoma". Int. J. Oneal., 2000, 17, 55.

[5] Noshiro H., Chijiiwa K., Yamaguchi K., Shimizu S., Sugitani A., Tanaka M.: "Factors affecting surgical outcome for gallbladder carcinoma". Hepatogastroenterology, 2003, 50, 939.

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