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Bilateral gonadoblastoma with extended calcification: Case report of a tumor developing on dysgenetic gonads

  • A. Kondi-Pafiti1,*,
  • D. Grapsa1
  • D. Hasiakos1
  • A. Kontorabdis1

1Pathology Laboratory, 2"d Clinic for Obstetrics and Gynecology University of Athens, Aretaieion hospital Athens, Greece

DOI: 10.12892/ejgo200503330 Vol.26,Issue 3,May 2005 pp.330-332

Published: 10 May 2005

*Corresponding Author(s): A. Kondi-Pafiti E-mail:

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Abstract

Gonadoblastoma is a rare tumor occurring almost exclusively in phenotypic females with intersex disorders and dysgenetic gonads. We report a case of gonadoblastoma in an 18-year old female who was admitted to our hospital for the investigation of primary amenorrhea. The patient underwent bilateral gonadectomy. A histopathologic study revealed streak gonads with extended calcification and bilateral gonadoblastoma. We describe the histopathologic features of gonadoblastoma and the pattern of its potential malignant transformation. Difficulties in the histological diagnosis of this rare tumor are also discussed. The need for early prophylactic removal of dysgenetic gonads, especially in patients that carry the Y chromosome, is emphasized.

Keywords

Gonadoblastoma; Dysgenetic gonads; Dysgerminoma; Germ cells; Calcification

Cite and Share

A. Kondi-Pafiti,D. Grapsa,D. Hasiakos,A. Kontorabdis. Bilateral gonadoblastoma with extended calcification: Case report of a tumor developing on dysgenetic gonads. European Journal of Gynaecological Oncology. 2005. 26(3);330-332.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200503330

References

[1] Rosai J., Ackerman L.V.: "Female reproductive system". In: Rosai J. (ed.). Surgical Pathology. Edinburgh, Mosby, 2004, 1704.

[21 Bjersing L., Cajander S.: "Ultrastructure of gonadoblastoma and dysgerminoma (seminoma) in patient with XY gonadal dysgenesis". Cancer, 1977, 40, 1127.

[3] Nakashima N., Nagasaka T., Fukata S., Oiwa N., Nara Y., Fukatsu T. et al.: "Ovarian gonadoblastoma with dysgerminoma in a woman with two normal children". Hum. Pathol., 1989, 20, 814.

[4] Talerman A.: "Germ cell tumors of the ovary". In: Kurman R.J. (ed.). Blaustein's Pathology of the Female Genital Tract. New York, Springer, 2002, 1017.

[5] Casenave F., Saurel J., Boutet G., Parneix I., Brun G "Gonadoblastoma. Review of the literature. A propos of a case". J. Gynecol. Obstet. Biol. Reprod. (Paris), 1986, 15, 757.

[6] Scully R.E.: "Gonadoblastoma. A review of 74 cases". Cancer, 1970, 25, 1340.

[7] Mackay A.M., Pettigrew N., Symington T., Neville A.M.: "Tumors of dysgenetic gonads (gonadoblastoma). Ultrastructural and steroidogenic aspects". Cancer, 1974, 34, 1108.

[8] Scully R.E.: "Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome". Cancer, 1970, 25, 1107.

[9] lkarashiT., Sudo N., Arakawa 0., Furuya M., Kato M., Hirashawa H. et al.: "46, XY pure gonadal dysgenesis with gonadoblastoma" Nippon Sanka Fujinka Gakkai Zasshi, 1989, 41, 1831.

[10] Kariminejad M.H., Movlavi M.A., Nassergodssi M.A., Ghafoorzadin D., Behjatnia Y.: "Gonadoblastoma associated with mixed gonadal dysgenesis". Am. J. Obstet. Gynecol., 1972, 113, 410.

[11] Berg F.D., Kurz! R., Hinrichsen M.J., Zander J.: "Familial 46, XY pure gonadal dysgenesis and gonadoblastoma/dysgserminoma case report". Gynecol. Oneal., 1989, 32, 261.

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