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Primary lymphoma of the cervix uteri: a diagnostic challenge. Report of two cases and review of the literature

  • N. Van Renterghem1
  • P. De Paepe2
  • R. Van den Broecke1,*,
  • C. Bourgain3
  • R. Serreyn1

1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Belgium

2Department of Pathology, Ghent University Hospital, Ghent, Belgium

3Department of Pathology, University Hospital Free University Brussels, Brussels, Belgium

DOI: 10.12892/ejgo20050136 Vol.26,Issue 1,January 2005 pp.36-38

Published: 10 January 2005

*Corresponding Author(s): R. Van den Broecke E-mail:

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Abstract

Background: Primary non Hodgkin's lymphoma (NHL) of the cervix and vagina is uncommon; the incidence of uterine lymphoma is estimated to be less than 0.5% of all NHL. Patients regularly present with vaginal bleeding. The diagnosis is made on biopsy but this can be difficult on small samples which may not be representative of the lesion. Immunohistochemical analysis and often molecular techniques are required to confirm the diagnosis.

Cases: We report two cases of primary diffuse large B-cell lymphoma of the cervix. In the first case, the diagnosis could only be made on repeat biopsies. The second case presented as a cervical polyp.

Conclusion: Gynecologists should be aware of this rare clinical entity in order to apply the proper treatment.

Keywords

Malignant lymphoma; Cervix; Diagnosis

Cite and Share

N. Van Renterghem,P. De Paepe,R. Van den Broecke,C. Bourgain,R. Serreyn. Primary lymphoma of the cervix uteri: a diagnostic challenge. Report of two cases and review of the literature. European Journal of Gynaecological Oncology. 2005. 26(1);36-38.

URL:

https://www.ejgo.net/articles/10.12892/ejgo20050136

References

[1] Dhimes P., Alberti N., De Agustin P.: "Primary malignant lymphoma of the uterine cervix: report of a case with cytologic and immunohistochemical diagnosis". Cytopathology, 1996, 7, 204.

[2] Freeman C., Berg J., Cutler W.: "Occurence and prognosis of extranodal lymphomas". Cancer, 1972, 29, 252.

[3] Perren T., Farrant M., McCarthy K.: "Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature". Gynecol. Oneal., 1992, 44, 87.

[4] Mann R., Roberts W., Gunasakeran S.: Primary lymphoma of the uterine cervix". Gynecol. Oneal., 1987, 26, 127.

[5] Broekmans F., Swartjes J., Van der Valk P.: "Primary malignant lymphoma of the uterus: localization in a cervical polyp". Eur. J. Obstet. Gynaecol., 1993, 48, 215.

[6] Krumerman M., Chung S.: "Solitary reticulum cell sarcoma of the uterine cervix with initial cytodiagnosis". Acta Cytol., 1978, 22, 46.

[7] Al-Talib R., Sworn M., Ramsay A.: "Primary cervical lymphoma: the role of cervical cytology". Cytopathology, 1996, 7, 173.

[8] Dhimes P., Alberti N., De Agustin P.: "Primary malignant lymphoma of the uterine cervix: report of a case with cytologic and immunohistochemical diagnosis". Cytopathology, 1996, 7, 204.

[9] Carbone P., Kaplan H., Musshoff K., Smithrs D., Tubiana M.: "Report of the committee on Hodgkin's Disease staging classification". Cancer Res., 1971, 31, 1860.

[10] Lathrop J.: "Malignant pelvic lymphomas". Obstet. Gynecol., 1967, 30, 137.

[11] Harris N., Scully R.: "Malignant lymphoma and granulocytic sarcoma of the uterus and vagina: A clinico-pathologic analysis of 27 cases". Cancer, 1984, 53, 2530.

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