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Coexistence of Brenner tumor and struma ovarii: case report

  • K. Takeuchi1,*,
  • C. Ohbayashi2
  • S. Kitazawa3
  • N. Ohara1
  • T. Maruo1

1Department of Obstetrics and Gynecology, Japan

2Division of Surgical Pathology, Japan

3Division of Molecular Pathology, Kobe University Graduate School of Medicine, Kobe, Japan

DOI: 10.12892/ejgo200501109 Vol.26,Issue 1,January 2005 pp.109-110

Published: 10 January 2005

*Corresponding Author(s): K. Takeuchi E-mail:

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Abstract

Background: There has been controversy regarding the histogenesis of Brenner tumors. It is generally accepted that Brenner tumors are derived directly from ovarian surface epithelium, which undergoes metaplasia to form the typical urothelial-like components, whereas some investigators assume that Brenner tumors arise from immature germ cells.

Case: We describe a well-documented case of the coexistence of struma ovarii regarded as a form of teratoma and Brenner tumor in the same ovary. Immunohistologically, not only columnar cells of thyroid follicles, but also transitional cells of Brenner nests were positive for thyroglobulin.

Conclusions: In the present case, Brenner tumors and thyroid elements coexisted and were positive for thyroglobulin. While there is strong evidence that pure Brenner tumors originate mostly from the ovarian surface, at least Brenner tumors associated with teratomatous elements may have a germ cell origin.

Keywords

Brenner tumor; Struma ovarii; Thyroglobulin

Cite and Share

K. Takeuchi,C. Ohbayashi,S. Kitazawa,N. Ohara,T. Maruo. Coexistence of Brenner tumor and struma ovarii: case report. European Journal of Gynaecological Oncology. 2005. 26(1);109-110.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200501109

References

[1] Russell P.: "Surface epithelial-stromal tumours of the ovary". In F ox H. (ed.). Haines & Taylor Obstetric and Gynecological Pathology, New York, Churchill Livingstone, 1995, 743.

[2] Nogales F.F.: "Germ cell tumours of the ovary". In: Fox H. (ed.) Haines & Taylor Obstetric and Gynecological Pathology. New York, Churchill Livingstone, 1995, 847.

[3] Moon S., Waxman M.: "Mixed ovarian tumor composed of Brenner and thyroid elements". Cancer, 1976, 38, 1997.

[4] Chiarelli S.M., Onnis G.L.: "Coexisting Brenner tumor and struma ovarii: case report". Eur. J. Gynaecol. Oneal., 1980, 1, 108.

[5] Carinelli S.G., Senzani F., Carinelli I., Cefis F.: "Struma ovarii and Brenner tumor". Tumori, 1981, 67, 581.

[6] Elemenoglou A., Zizi-Serbetzoglou A., Trihia H., Yasilakaki T., Bournia E.: "Mixed ovarian neoplasm composed of struma ovarii and Brenner tumour". Eur. J. Gynaecol. Oneal., 1994, 15, 138.

[7] Burg J., Kommoss F., Bittinger F., Moll R., Kirkpatrick C.J "Mature cystic teratoma of the ovary with struma and benign Brenner tumor: a case report with immunohistochemical charaterization". Int. J. Gynecol. Pathol., 2001, 21, 74.

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