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Primary ovarian carcinosarcoma: a case report and review of the literature
13rd Department of Obstetrics and Gynaecology, University General Hospital "AITIKON", Athens,Third District National Health System, Athens, Greece
2Department of Obstetrics and Gynaecology, "G. Chatzikosta" General State Hospital, Ioannina, District National Health System, Epirus, Greece
3Department of Internal Medicine, Medical School, University Hospital, Joannina, District National Health System, Epirus, Greece
4Department of Pathology, "G. Chatzikosta" General State Hospital, Joannina, District National Health System, Epirus, Greece
*Corresponding Author(s): M. Varras E-mail: mnvarras@otenet.gr
Primary ovarian carcinosarcoma is characterized by an admixture of malignant epithelial and stromal elements. This neoplasm is extremely rare with fewer than 400 cases reported in the English literature. Its histogenesis, clinical features and optimal treatment remain unclear because of the rarity of primary ovarian carcinosarcoma. This study focuses on the clinical, pathological, immunohistochemical features and survival of a 73-year-old patient with primary ovarian carcinocarcoma. The patient was treated with surgery followed by combined chemotherapy with carboplatin and taxol and assigned to FIGO Stage IIIc. She died from the disease 17 months after surgery. In conclusion, ovarian carcinosarcoma is a very aggressive tumor, especially when it is diagnosed at advanced stage.
Carcinosarcoma; Ovary; Malignant mixed mesodennal; Mixed Miillerian; Tumor; Pathology; Chemotherapy; Survival
M. Varras,Ch. Akrivis,N. Antoniou,C. Tolis,S. Stefanaki,E. Salamalekis. Primary ovarian carcinosarcoma: a case report and review of the literature. European Journal of Gynaecological Oncology. 2004. 25(5);653-656.
[1] Melilli G.A., Nappi L., Carriero C., Loizzi V., Caradonna F., Quaranta M., Putignano G.: "Malignant mixed mullerian tumor of the ovary: report of four cases". Eur. J. Gynaecol. Oneal., 2001, 22, 67.
[2] Wei L.H., Huang C.Y., Cheng S.P., Chen C.A., Hsieh C.Y.: "Carcinosarcoma of ovary associated with previous radiotherapy". Int J. Gynecol. Cancer, 2001, 11, 81.
[3] Elbers J.R.J., Wagenaar S.S.: "Malignant mixed mesodermal tumor of the ovary". Eur. J. Obstet. Gynecol. Reprod. Biol., 1980, 10, 47.
[4] Grover V.,D hall K.,G rover R.K.,C houdhry T.: "Malignant mixed mesodermal tumor of ovary". Eur. J. Obstet. Gynecol. Reprod. Biol., 1985, 20, 241.
[5] Hellstrom A.C., Tegerstedt G., Silfverward C., Pettersson F.: "Malignant mixed mtillerian tumors of the ovary: histopathologic and clinical review of 36 cases". Int. J. Gynecol. Cancer, 1999, 9, 312.
[6] Van Rijswijk R.E.N.,T ognon G.,B urger C.W.,B aak J.P.,K enemas P., Vermorken J.B.: "The effect of chemotherapy on the different components of advanced carcinosarcomas (malignant mixed mesodermal tumors) of the female genital tract". Int. J. Gynecol Cancer, 1994, 4, 52.
[7] Prendiville J.,M urphy D.,R enninson J.,B uckley H.,C rowther D.: "Carcinosarcoma of the ovary treated over a 10-year period at the Chritie Hospital". Int. J. Gynecol. Cancer, 1994, 4, 200.
[8] Meiss J.M., Lawrence W.D. "The immunohistochemical profile of malignant mixed Mtillerian tumor". Am. J. Clin. Pathol., 1990. 94, 1.
[9] Hanjani P., Petensen R.O., Lipton S.E., Nolte S.A.: "Malignant mixed mesodermal tumours and carcinosarcoma of the ovary· report of eight cases and review of the literature". Obstet Gynaecol. Sur.. 1983, 38, 537.
[10] Morrow C.P., D'Ablaing G., Blady L.W.: "A clinical and pathologic study of 30 cases of malignant mixed mullerian epithelial and mesenchymal ovarian tumors. A Gynecologic Oncology Group Study". Gynecol. Oneal., 1984, 18, 278.
[11] Andersen WA., Young D.E., Peters W.A. 3rd, Smith E.B., Bagley C.M., Taylor P.T. Jr.: "Platinum-based combination chemotherapy for malignant mixed mesodermal tumors of the ovary". Gynecol. Oncol., 1989, 32, 319.
[12] Pfeiffer P., Hardt-Madsen M., Rex S., Hoelurn B., Bertelsen K.: "Malignant mixed miillerian tumors of the ovary. Report of 13 cases". Acta Obstet. Gynecol. Scand., 1991, 70, 79.
[13] Eicher A., Levenback C., Silva E.G., Burke T.W., Morris M., Gershenson D.M.: " Ovarian malignant mixed miillerian tumors treated with platinum-based chemotherapy". Obstet. Gynecol., 1995, 85, 735.
[14] Le T., Krepart G.V., Lotocki R.J., Heywood M.S.: "Malignant mixed mesodermal tumor treatment and prognosis: A 20-year experience". Gynecol. Oncol., 1997, 65, 237.
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