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Chemotherapy for ovarian mucinous cystadenocarcinoma during pregnancy: A case report

  • H.-P. Huang1
  • C.-N. Fang1,*,
  • Y.-Y. Kan1,2

1Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Republic of China

2National Yang-Ming Medical University, Taipei, Taiwan, Republic of China

DOI: 10.12892/ejgo200405635 Vol.25,Issue 5,September 2004 pp.635-636

Published: 10 September 2004

*Corresponding Author(s): C.-N. Fang E-mail:

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Abstract

There is limited experience in the treatment of epithelial ovarian malignancy with chemotherapy during pregnancy. We present the case of a 36-year-old women with ovarian mucinous cystadenocarcinoma during pregnancy, on whom exploratory laparotomy was performed at the gestational age of 16 weeks. Afterwards chemotherapy with cyclophosphamide (500 mg/m2) and cisplatin (50 mg/m2) was administered beginning at the second trimester of pregnancy due to surgical Stage Ic. Although preterm labor and a prematurely ruptured membrane occurred at the gestational age of 29 weeks before the fourth course of chemotherapy, there was still a satisfactory outcome for mother and fetus after an emergency cesarean section due to breech presentation at the gestational age of 30 weeks.

Keywords

Ovarian malignancy; Chemotherapy; Pregnancy

Cite and Share

H.-P. Huang,C.-N. Fang,Y.-Y. Kan. Chemotherapy for ovarian mucinous cystadenocarcinoma during pregnancy: A case report. European Journal of Gynaecological Oncology. 2004. 25(5);635-636.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200405635

References

[1] Hoffman M., Cavanagh D., Walter T., lonata E., Ruffolo E.: "Adenocarcinoma of the endometrium with pregnancy". Gynecol Oneal., 1989, 32, 82

[2] Doll D.C., Ringenberg S., Yarbo J.W.: "Antineoplastic agents and pregnancy". Semin. Oncol., 1989, 16, 337

[3] Ebert U., Loffler H., Kirch W.: "Cytotoxic therapy and pregnancy". Pharmacol. Ther., 1997, 74 (2), 207.

[4] Raffles A., Williams J., Costeloe K., Clark P.: "Transplacental effects of maternal cancer chemotherapy: Case report". Br..I Obstet. Gynaecol., 1989, 96, 1099.

[5] Kai S., Kohmura H., Hiraiwa E. et al.: "Reproductive and developmental toxicity studies of paclitaxel. IL Intravenous administration to rats during the fetal organogenesis". J. Toxicol. Sci., 1994, 19S, 69.

[6] Sood AK., Shahin M.S., Sorosky J.I.: "Paclitaxel and platmum chemotherapy for ovarian carcinoma during pregnancy". Gynecol Oncology, 2001, 83 (3), 599.

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