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Original Research

Open Access

Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary

  • I. Sahin1,*,
  • Z. Yilmaz2
  • F.I. Sahin2

1Obstetrics and Gynecology Clinic, Ankara Numune Education and Research Hospital, Turkey

2Department of Medical Biology and Genetics, Baskent University, Ankara, Turkey

DOI: 10.12892/ejgo200405585 Vol.25,Issue 5,September 2004 pp.585-586

Published: 10 September 2004

*Corresponding Author(s): I. Sahin E-mail:

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Abstract

Purpose of investigation: Epithelial ovarian tumors are usually mucinous or serous type, affecting nearly 1% of women during their lifetime. They may be regarded as benign, borderline or invasive according to pathological examination. Karyotypes of the tumor provide critical information about both the genetic predisposition and the stage of the tumor. We aimed to investigate the correlation between karyotype findings and the stage of the serous papillary tumors of the ovary.

Methods: Tissue cultures were set up from 15 serous papillary adenocarcinoma samples of different stages and examined cytogenetically.

Results: The most common chromosome abnormalities included both numerical and structural abnormalities of chromosomes 1, 3,6,7,8, 11, 21, 22 and X.

Conclusion: Karyotypes became more complex, as expected, with the later stages.

Keywords

Serous papillary ovarian cancer; Cytogenetic abnormality

Cite and Share

I. Sahin,Z. Yilmaz,F.I. Sahin. Cytogenetic abnormalities in serous papillary adenocarcinoma of the ovary. European Journal of Gynaecological Oncology. 2004. 25(5);585-586.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200405585

References

[1] Evans M.F., McDiken I.W., Herrington S.C.: "Numerical abnormalities of chromosomes I, I I, 17, and X are associated with stromal invasion in serous and rnucinous epithelial ovarian tumours". J. Pathol., 1999, 189, 53.

[2] Pejovic T.: "Genetic changes in ovarian cancer". Ann. Med., 1995, 27, 73.

[3] Taetle R., Aickin M., Yang J-M., Panda L., Emerson J., Roe D. et al.: "Chromosome abnormalities in ovarian adenocarcinoma: 1 Nonrandom chromosome abnormalities from 244 cases". Genes Chromosomes Cancer, 1999, 25, 290.

[4] Verma S.R., Babu A.: "Tissue Culture Techniques and Chromosome Preparation". In: Verma S.R., Babu A. (eds.). Human Chromosomes Principles and Techniques. New York: McGraw-Hill Inc., 1995, 6.

[5] Iwabuchi H., Sakamato M., Sakunaga H., Ma Y-Y., Carcangiu M.L., Pinke! D.: "Genetic analysis of benign, low-grade, and highgrade ovarian tumors". Cancer Res., 1995, 55, 6172.

[6] Wang N.: "Cytogenetics and molecular genetics of ovarian cancer" Am. J. Med. Genet., 2002, 115, 157.

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