Article Data

  • Views 247
  • Dowloads 107

Original Research

Open Access

Fibroadenomas of the breast: is there any association with breast cancer?

  • C. Markopoulos1
  • E. Kouskos1,*,
  • D. Mantas1
  • K. Kontzoglou1
  • Z. Antonopoulou1
  • K. Revenas1
  • V. Kyriakou1

1Breast Unit-2nd Surgical Department, School of Medicine-Laiko Hospital, Athens and 2nd Surgical Department, Vostanio General Hospital of Mytilene, Lesvos Island, Greece

DOI: 10.12892/ejgo200404495 Vol.25,Issue 4,July 2004 pp.495-497

Published: 10 July 2004

*Corresponding Author(s): E. Kouskos E-mail:

Abstract

Purpose: The experience of our Breast Unit in the diagnosis and treatment of fibroadenomas is presented in this retrospective study, focusing specifically in cancer development within these common benign tumors of young age.

Material-methods: 310 women with histologically verified breast fibroadenomas who had surgical management in our Unit over the last 14 years were included in the study.

Results: Most of them (n: 255) presented with palpable lesions and had triple assessment preoperatively, while the remaining 55 had nonpalpable lesions and underwent needle-wire localization biopsies. Nine cases had cancer development, usually in situ, within the fibroadenomas (2.9%).

Conclusion: Coexistence of fibroadenomas and breast cancer is relatively rare, but it should not be ignored by breast surgeons, and patients should be properly informed.

Keywords

Fibroadenoma; Breast cancer; Mammography; Ultrasonography; Cytology; Biopsy

Cite and Share

C. Markopoulos,E. Kouskos,D. Mantas,K. Kontzoglou,Z. Antonopoulou,K. Revenas,V. Kyriakou. Fibroadenomas of the breast: is there any association with breast cancer? . European Journal of Gynaecological Oncology. 2004. 25(4);495-497.

References

[1] Hindle W.H., Alonzo L.J.: "Conservative management of breast fibroadenomas". Am. J. Obstet. Gynecol., 1991, 164, 1647.

[2] Wilkinson S., Forest A.P.M.: "Fibroadenoma of the breast". Br. J. Surg., 1985, 72, 838.

[3] Cant P.J., Madden M.V., Close P.M., Learmonth G.M.: "Case for conservative management of selected fibroadenomas of the breast". Br. J. Surg., 1987, 74, 857.

[4] Brenner R.J., Sickles E.A.: "Acceptability of periodic follow-up as an alternative to biopsy for marnmographically detected lesions interpreted as probably benign". Radiology, 1989, 171, 645.

[5] Gordon P.B., Gagnon P.A., Lanzkowsky L.: "Solid breast masses diagnosed as fibroadenoma at fine needle aspiration biopsy: acceptable rates of growth at long-term follow-up". Radiology, 2003, 229, 233.

[6] Yilmaz E., Sal S., Lebe B.: "Differentiation of phylloides tumors versus fibroadenomas". Acta Radiol., 2002, 43, 34.

[7] Rogers L.A., Lee K.R.: "Breast carcinoma simulating fibroadenoma or fibrocystic change by fine-needle aspiration". Am. J. Clin. Pathol., 1992, 98, 155.

[8] Scolyer R.A., McKenzie P.R., Achmed D., Lee C.S.: "Can phyllodes tumours of the breast be distinguished from fibroadenomas using fine needle aspiration cytology?". Pathology, 2001, 33, 437.

[9] Vaideeswar P., Madiwale C., Sivaraman A.: "Carcinoma arising within fibroadenoma: a case report". Indian J. Pathol. Microbiol., 2000, 43, 87.

[10] Sperber F., Blank A., Metser U., Flusser G., Klausner J.M., LevChelouche D.: "Diagnosis and treatment of breast fibroadenomas by ultrasound-guided vacuum-assisted biopsy". Arch. Surg., 2003, 138, 796.

[11] Sheth D., Wesen C.A., Schroder D., Boccaccio J.E., Lloyd L.R.: "The advanced breast biopsy instrumentation (ABBI) experience at a community hospital". Am. Surg., 1999, 65, 726.

[12] Markopoulos C., Kakisis J., Kouskos E., Kontzoglou K., Koufopoulos K., Gogas J.: "Management of nonpalpable, mammographically detectable breast lesions". World J. Surg., 1999, 23, 434.

[13] Yano Y., Ueno E., Kamma H., Tsunoda H., Hara H., Yashiro T. et al.: "Non-invasive lobular carcinoma within a fibroadenoma, a preoperatively diagnosed case". Breast Cancer, 2001, 8, 70.

[14] Yoshida Y., Takaoka M., Fukumoto M.: "Carcinoma arising in fibroadenoma: case report and review of the world literature". J. Surg. Oncol., 1985, 29, 132.

[15] Baker K.S., Monsees B.S., Diaz N.M., Destouet J.M., McDivitt R.W.: "Carcinoma within fibroadenomas: mammographic features". Radiology, 1990, 176, 371.

[16] Kuijper A., P reisler-Adams S.S., Rahusen F.D., Gille J.J., van der Wall E., van Diest P.J.: "Multiple fibroadenomas harbouring carcinoma in situ in a woman with a family history of breast/ovarian cancer". J. Clin. Pathol., 2002, 55, 795.

[17] El-Wakeel H., Umpleby H.C.: "Systematic review of fibroadenoma as a risk factor for breast banker". Breast, 2003, 12, 302.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top