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Original Research

Open Access

Mammographic changes during postmenopausal hormonal replacement therapy with tibolone

  • A. Pantidou1,*,
  • K. Kaplanis1
  • I. Chrissogonidis1
  • C. Destouni1

1Department of Cytopathology, "Theagenio" Anticancer Hospital of Thessaloniki, Greece

DOI: 10.12892/ejgo200404493 Vol.25,Issue 4,July 2004 pp.493-494

Published: 10 July 2004

*Corresponding Author(s): A. Pantidou E-mail:

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Abstract

Purpose of investigation: To evaluate mammographic changes in postmenopausal women receiving hormonal replacement therapy (HRT) with tibolone.

Methods: 83 postmenopausal women aged 45-62 received the same dose of tibolone for a period of six months to five years without interruption. The women were examined mammographically every six to 12 months during the observation period.

Results: There was a low incidence of breast tenderness. Also, we did not observe any significantly increased mammographic density or neoplasmatic disease of the breast. As far as dysplastic changes are concerned, no remarkable aggravation in the mammographic picture was noted.

Conclusion: The new synthetic steroid tibolone, in contrast to conventional HRT, rarely causes breast pain. At least short-period tibolone therapy (less than 5 years) has good effects on climacteric disorders and does not cause breast changes (dysplasia or cancer). Our study is on-going.

Keywords

Hormone replacement therapy; Tibolone; Mammographic density

Cite and Share

A. Pantidou,K. Kaplanis,I. Chrissogonidis,C. Destouni. Mammographic changes during postmenopausal hormonal replacement therapy with tibolone. European Journal of Gynaecological Oncology. 2004. 25(4);493-494.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200404493

References

[1] Berkowitz J.E., Gatewood O.M.B., Goldblum L.E., Gayler B.W.: "Hormonal replacement therapy: mammographic manifestations". Radiology, 1990, 174, 199.

[2] Erel C.T., Seyisoglu H., Senturk M.L., Alanan C., Ersavasti G., Benian A. et al.: "Mammographic changes in women on hormonal replacement therapy". Maturitas, 1996, 25, 51.

[3] Laya M.B., Gallagher J.C., Schreiman J.S., Larson E.B., Watson P., Weinstein L.: "Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern". Radiology, 1995, 196, 433.

[4] McNicholas M.M.J., Heneghan J.P., Milner M.A., Tunney T., Hourihane J.B., MacErlaine D.P.: "Pain and increased mammographic density in women receiving hormone replacement therapy a prospective study". A.J.R. Am. J. Roentgenol., 1994, 163, 311.

[5] Stomper P.C., Von Voorkis B.J., Ravnikar V.A., Meyer J.E.: "Mammographic changes associated with postmenopausal hormone replacement therapy: a longitudinal study". Radiology, 1990, 174, 487.

[6] Cemal T.E., Koray E., Canan A., Gui E., Ayca A., Hakan S. et al.: "Mammographic changes in women receiving tibolone therapy" Fertil. Steril., 1998, 69, 870.

[7] Coelingh Bennink H. J. T.: "Clinical experience with tibolone, a tissue-specific hormone". Gynecol. Endocrinol., 1997, II (suppl. 1), 57.

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