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Treatment delay and pathology results in women with low-grade squamous intraepithelial lesions. A preliminary study

  • G. IATRAKIS1,*,
  • G. Kourounis2
  • N. Georgopoulos3
  • J. Karachotzitis4

1Department of Obstetrics and Gynecology of the Technological Educational Institution of Athens, Greece

2Department of Obstetrics and Gynecology, University of Patra, Greece

3University of Patra, Greece

4Maternal and Surgical Center, Athens, Greece

DOI: 10.12892/ejgo200403376 Vol.25,Issue 3,May 2004 pp.376-378

Published: 10 May 2004

*Corresponding Author(s): G. IATRAKIS E-mail:

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Abstract

Regression rate of CIN 1 (LSIL) can reach 85%. The purpose of this study was to investigate retrospectively pathology specimens in CIN 1 cases who delayed treatment > 2 years despite the persistence of the lesion. One hundred and fifteen women diagnosed with CIN 1 were separated in two groups as follows: A) 92 women who underwent ablative treatment within three months after the completion of two years; B) 23 women who delayed ablative treatment for a mean interval of > 1 year after the completion of two years. Exclusion criteria were normal cytology and colposcopy results within the completion of two years. The chi-square, t-test and Kaplan-Meier method were used for analysis. Persistence of LSIL lesions was observed in 84% of the first group and persistence or regression of the lesion in 78% of the second one. The study suggests the possibility of prolongation of the observation period after LSIL diagnosis. Prospective studies with close follow-up are needed for final conclusions.

Keywords

CIN 1; LSIL; HSIL; Ablative treatment

Cite and Share

G. IATRAKIS,G. Kourounis,N. Georgopoulos,J. Karachotzitis. Treatment delay and pathology results in women with low-grade squamous intraepithelial lesions. A preliminary study. European Journal of Gynaecological Oncology. 2004. 25(3);376-378.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200403376

References

[1] Lee S.S.N., Collins R.J., Pun T.C.: "Conservative treatment of low grade squamous intraepithelial lesions (LSIL) of the cervix". Int. J Obstet. Gynecol., 1998, 60, 35.

[2] Falls R.K.: "Spontaneous resolution rate of grade I cervical intraepithelial neoplasia in a private practice population". Am. J. Obstet. Gynecol., 1999, 181, 278.

[3] Hatch K.D., Berek J.S.: "Intraepithelial disease of the cervix, vagina, and vulva". In: Novak's Gynecology. Philadelphia, Lippincott Williams & Wilkins, 2002.

[4] Frega A., Stentella P., De loris A., Piazze J.J., Fambrini M., Marchionni M. et al.: "Young women, cervical intraepithelial neoplasia and human papillomavirus: risk factors for persistence and recurrence". Cancer Lett., 2003, 196, 127.

[5] ldestrom M., Milsom I., Andersson-Ellstrom A.: "Women's experience of coping with a positive Pap smear: a register-based study of women with two consecutive Pap smears reported as CIN 1 ". Acta Obstet. Gynecol. Scand., 2003, 82, 756.

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