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Angiomyofibroblastoma of the vulva: report of a case

  • F. Montella1,*,
  • M. Giana1
  • A. Vigone1
  • D. Surico1
  • N. Surico1

1Department of Obstetrics and Gynaecology, "Piemonte Orientate" University, Novara, Italy

DOI: 10.12892/ejgo200402253 Vol.25,Issue 2,March 2004 pp.253-254

Published: 10 March 2004

*Corresponding Author(s): F. Montella E-mail:

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Abstract

A case of solitary angiomyofibroblastoma of the vulva in a 16-year-old woman was examined by histology and immunohistochemistry. Microscopic examination of the tumor revealed typical features of a mesenchymal neoplasm, composed of bundle spindle cells with low cellular density, rich in collagen fibers and thin-walled blood vessels. Immunohistochemistry revealed immunoreactivity for progesterone receptor, CD34, desmin and vimentin, tumor cells expressing positivity, but not for estrogen receptors. The stains for the muscle-specific actin and S-100 were negative. These results were mostly consistent with those of previous reports and suggest that the tumors cells were derived from primitive mesenchymal cells which occur normally in this region and show the potential for diverse lines of myoid differentiation.

Keywords

Angiomyofibroblastoma; Desmin; CD34; Vulva

Cite and Share

F. Montella,M. Giana,A. Vigone,D. Surico,N. Surico. Angiomyofibroblastoma of the vulva: report of a case. European Journal of Gynaecological Oncology. 2004. 25(2);253-254.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200402253

References

[1] Fletcher C.D.M., Tsang W.Y.W., Fisher C., Lee K.C., Chan J.K.C.: "Angiomyofibroblastoma of the vulva: a benign neoplasm distinct from aggressive angiomyxoma". Am. J. Surg Pathol., 1992, 16, 373.

[2] Van der Griend M.D., Burda P., Ferrier A.J.: "Angiomyofibroblastoma of the vulva". Gynecol. Oneal., 1994, 54, 389.

[3] Ockner D.M., Saya小H., Swanson P.E., Ritter J.H., Wick M.R "Genital angiomyofibroblastoma. Comparison with aggressive angiomyxoma and other myxoid neoplasm of skin and soft tissue" Am. J. Clin. Pathol., 1997, 107, 45.

[4] McCluggage W.G., White R.G.: "Angiomyofibroblastoma of the vagina". J. Clin. Pathol., 2000, 53, 803.

[5] Kavak Zn., Basgul A., Eren F., Ceyhan N.: "Angiomyofibroblastoma of the vulva: a rare but distinct entity". Acta Ob.stet. Gynecol. Scand., 2000, 79, 612.

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