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The role of leptin in breast cancer

  • A. Markowska1,*,
  • K. Malendowicz1
  • K. Drews1

1Department Perinatology, University of Medical Sciences in Poznan, Poland

DOI: 10.12892/ejgo200402192 Vol.25,Issue 2,March 2004 pp.192-194

Published: 10 March 2004

*Corresponding Author(s): A. Markowska E-mail:

Abstract

Leptin, the protein hormone produced mainly by adipocytes, placenta and mammary epithelium plays a significant role in, e.g., control of metabolism, reproductive processes, immune processes, angiogenesis, haemopoiesis and oxidation of lipids. Since some authors link leptin to mechanisms of mammary cancer development, the clinical data has been screened to allow evaluation of the hypothesis.

Keywords

Leptin; Breast cancer

Cite and Share

A. Markowska,K. Malendowicz,K. Drews. The role of leptin in breast cancer. European Journal of Gynaecological Oncology. 2004. 25(2);192-194.

References

[1] Mantzoros Ch.S.: "T he role of leptin In human obesity and disease: A review of current evidence". Ann. Intern. Med., 1999,130, 671.

[2] Wiesner G., Vaz M.,C ollier G. et al.: "Lcptin is related from the human brain: Influence of adiposity and gender". J. Clin. Endocrinol. Metab., 1999, 84, 2270.

[3] Sierra-Honigmann M.R., Nath A.K.. Murakami C. et al.: "B10-logical action of leptin as an angiogcnic factor". Science, 1998. 81, 1683.

[4] Baumann H., Morella K.K, White D.W. et al.:'The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptor". Proc. Natl. Acad. Sci. USA , 1996, 93, 8374.

[5] Ihle J.N., Stats: "Signal transducers and activators of transcription". Cell., 1996, 84, 331.

[6] Mantzoros C.S., Bolhke K., Moschos S.. Cramer D.W.: "Lcptin in relation to carcinoma in situ of the breast: a study of premenopausal cases control". Int. J. Cancer, 1999, 80 (4), 523.

[7] Caro J.F., Kolaczynski J.V., Nyce M.R. et al.: "Decreased carebrospinal-fluid, serum leptin ratio in obesity: a possible mechanism for leptin resistance". Lancet, 1996, 348, 159.

[8] Considine R.U., Siha M.K., H eiman M.L. et al.:''Serum immunoreactive-leptin concentration in normal-weight and obese humans". N. EnJ?I. J. Med., 1996, 334, 292.

[9] Strobel A.,l ssad T.,C amoin L. et al: “A leptin missense mutation associated with hypogonadism and morbid obesity''. Nat. Genet., 1998, 18, 213.

[10] Clement K., Garner C., Hager J. et al.: "Indication for linkage of the human OB gene region with extreme obesity". Diabetes, 1996, 45, 687.

[11] Dieudonne M.N., Machinal-Quelin F., Serazin-Leroy U. et al "Leptin mediates a proliferative response in human MCF 7 breast cancer cells". Bioch. Biophys. Res. Comm., 2002, 293 (1), 622.

[12] Laud K., Gourdou J., Pessemesse L. et al.: "Indentification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line". Mo/. Cell. Enclocrinol., 2002, 188, (1-2), 219.

[13] Hu X., Juneja S.C, Maihle N.J., Cleary M.P.: "Leptin - a growth factor in normal mammary gland development". J. Natl. Cancer Inst., 2002, 94 (22), 1704.

[14] O'Brien S.N., Welter B.H., Price T.M., Clemson S.G.: "Presence of leptin in breast cell lines and breast tumors". Biochem. Biophys. Res. Comm., 1999, 259, 695.

[15] Peyrat J.P., Bonneterre J., Hecquet B. et al.: "Plasma insulin-like growth factor-I (IGF-1) concentrations in human breast cancer". Ew: J. Cancer, 1993, 29A, 492.

[16] Bohlke K., Cramer D.W., Trichopolus D., Mantzaros C.S.: "Insulin-like growth factor-I relation to premenopausal ductal carcinoma in situ of the breast". Epidemiology, I 998, 9, 570.

[17] Bruning P.F., Van Doorn J., Bonfrer J.M. et al.: "Insulin-like growth-factor-binding protein 3 is decreased in early stage operable pre-menopausal breast cancer" . Int. J. Cancer, 1995, 62, 266.

[18] Petriodou E., Papadimanti、Y., Markopulos C.H. et ell.: "Leptin and insulin-like growth factor-I in relation to breast cancer (Greece)". Cancer Caus. Contr., 2002, 11, 383.

[19] Ozet A., Arpaci F., Yilmaz M.I. et ell.: "Effects of tamoxifen on the serum leptin level in patients with breast cancer". Jpn. J. Clin Oncol., 2001, 31 (9), 424.

[20] Tessitore L., Vizio B., Jenkin、0. et ed.: "Leptin expression in colorectal and breast cancer patients". Int. J. Mo/. Med., 2000, 5, 421.

[21] Christensen D.: "Leptin links diet to breast cancer". 10.IV.2003 http.bmn.com/news/stoni/day=03041.

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