Title
Author
DOI
Article Type
Special Issue
Volume
Issue
The benefits of haematopoietic growth factors in the management of gynaecological oncology
1Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA
*Corresponding Author(s): D. C. Dale E-mail:
Neutropenia and anemia are important complications of cancer chemotherapy and can be prevented and treated with granulocyte colony-stimulating factor and erythropoietin.
Chemotherapy-related neutropenia; Chemotherapy-related anemia; Cancer and quality of life; Hematopoietic growth factors; Granulocyte colony-stimulating factor; Erythropoietin
D. C. Dale. The benefits of haematopoietic growth factors in the management of gynaecological oncology. European Journal of Gynaecological Oncology. 2004. 25(2);133-144.
[1] Hughes W. T., Armstrong D., Bodey G. P., Brown A. E., Edwards J. E., Feld R. et al.: "1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever". Clin. Infect. Dis., 1997, 25, 551.
[2] Chang J.: "Chemotherapy dose reduction and delay in clinical practice: evaluating the risk to patient outcome in adjuvant chemotherapy for breast cancer". Eur. J. Cancer, 1999, 36 suppl. 1, S11.
[3] Ozer H., Armitage J. O., Bennett C. L., Crawford J., Demetri G.D., Pizzo P. A. et al.: "Update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines". J. Clin. Oneal., 2000, 18, 3558.
[4] ESMO: "ESMO recommendations for the application of haematopoietic growth factors (hGFs)". Ann. Oneal., 2001, 12, 1219.
[5] Dale D., Crawford J., Lyman G.: "Chemotherapy-induced neutropenia and associated complications in randomized clinical trials an evidence-based review". Proc. Am. Soc. Clin. Oneal., 2001, 20, 410a (Abstract 1638).
[6] Bodey G. P., Buckley M., Sathe Y. S., Freireich E. J.: "Quantitative relationships between circulating leukocytes and infection in patients with acute leukaemia". Ann. Intern. Med., 1966, 64, 328.
[7] Kuderer N. M., Cosler L., Crawford J., Dale D. C., Lyman G.: "Cost and mortality associated with febrile neutropenia in adult cancer patients". Proc. Am. Soc. Clin. Oneal., 2002, 21, 250a (Abstract 998)
[8] Trillet-Lenoir V., Green J., Manegold C., Von Pawel J., Gatzemeier U., Lebeau B. et al.: "Recombinant granulocyte colony stimulating factor reduces the infectious complications of cytotoxic chemotherapy". Eur. J. Cancer, 1993, 29A, 319.
[9] Bonadonna G., Valagussa P.: "Dose-response effect of adjuvant chemotherapy in breast cancer". N. Eng. J. Med., 1981, 304, 10.
[10] Dale D. C., McCarter G., Crawford J., Lyman G. H.: "Delivered dose intensity in randomized clinical trials (RCTs) of chemotherapy in early-stage breast cancer (ESBC) and non-Hodgkin's lymphoma (NHL): a need for improved reporting". Proc. Am Soc. Clin. Oneal., 2002, 21, 252a (Abstract 1004).
[11] Bonadonna G., Valagussa P., Moliterni A., Zambetti M., Brambilla C.: "Adjuvant cyclophosphamide, methotrexate and fluorouracil in node-positive breast cancer". N. Eng. J. Med., 1995, 332, 901.
[12] Kaye S. B., Lewis C. R., Paul J., Duncan I. D., Gordon H. K., Kitchener H. C. et al.: "Randomised study of two doses of cisplatin with cyclophosphamide in epithelial ovarian cancer". Lancet, 1992, 340, 329.
[13] Citron M., Berry D., Cirrinicione C., Carpenter J., Hudis C., Gradishar W. et al: "Superiority of dose-dense (DD) over conventional scheduling (CS) and equivalence of sequential (SC) vs. combination adjuvant chemotherapy (CC) for node-positive breast cancer (CALGB 9741, INT C9741)". Oral presentation at the 25'" Annual San Antonio Breast Cancer Symposium, December 11-13, 2002 (Abstract 15)
[14] Lyman G. H., Kuderer N. M., Agboola 0., Crawford J., Dale D. C.:'The epidemiology and economics of neutropenia in hospitalized cancer patients: data from the University HealthSystem Consortium". Blood, 2001, 98, 432a (Abstract 1813)
[15] Kuderer N. M., Crawford J., Dale D., Lyman G.: "Cost distributions and length of stay associated with febrile neutropenia in adult cancer patients". Supportive Care in Cancer, 2002, 10, 372 (Abstract P-71)
[16] Calhoun E. A., Welshman E. E., Change C-H., Lurain J. R., Bennett C. L.: "Cost of chemotherapy-induced neutropenia, thrombocytopenia and neurotoxicity". Proc. Am. Soc. Clin. Oncol., 2001, 20, 242a (Abstract 964).
[17] Erder M. H., Fridman M., Weaver C. H.: "Cancer patients (CPs ) perspectives about the impact of febrile neutropenia morbidity (FNM) on their well being (WB) and preferences for filgrastim treatment vs dose reduction to prevent FN: an internet survey" Proc. Am. Soc. Clin. Oneal., 2001, 20, 210b (Abstract 2589).
[18] Traynor B.: "Quality of life with filgrastim (r-metHuG-CSF)". In: "Filgrastim (r-metHuG-CSF) in Clinical Practice". Morstyn G., Dexter T. M. (eds). 1" edition. New York: Marcel Dekker, 1994, 319.
[19] Calhoun E. A., Chang C.-H., Welshman E. E., Cella D.: "Development and validation of the FACT-Neutropenia". Blood, 2001, 98, 427a (Abstract 1791).
[20] Calhoun E. A., Chang C.-H., Welshman E. E., Cella D.: "A neutropenia-specific quality of life instrument: rationale for the development of the FACT-N". Proc. Am. Soc. Clin. Oneal., 2002, 21, 375a (Abstract 1498)
[21] Pizzo P. A.: "Fever in immunocompromised patients". N. Engl. J. Med., 1999, 341, 893.
[22] Dale D.: "Management of febrile neutropenia: The shift from treatment to prevention". Oncol. Spectrums, 2002, 3, 6.
[23] Welte K. W., Gabrilove J., Bronchud M. H., Platzer E., Morstyn G.: "Filgrastim (r-metHuG-CSF): The first 10 years". Blood, 1996, 88, 1907.
[24] Heil G., Hoelzer D., Sanz M. A., Lechner K., Yin J. A. L., Papa G. et al.: "A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia". Blood, 1997, 90, 4710.
[25] Rivera E.,E rder M. H.,F ridman M.,B rannan C.,F rye D.,H ortobagyi G. N.: "Delivering full planned dose on time (PDOT) chemotherapy (CT) while lowering the incidence of febrile neutropenia (FN) hospitalizations: initial results form a prospective study (N=528) providing filgrastim support to high risk breast cancer patients (BCP)". Breast Cancer Res. Treat., 2001, 69, 209 (Abstract 3).
[26] De Graaf H., Willemse P. H. B., Bong S. B., Piersma H., Tjabbes T., van Veelen H. et al.: "Dose intensity of standard adjuvant CMF with granulocyte colony-stimulating factor for premenopausal patients with node-positive breast cancer". Oncology, 1996, 53, 289
[27] Ribas A., Albanell J., Bellmunt J., Sole-Calvo L.-A., Bermejo B., Gallardo E. et al.: "Five-day course of granulocyte colony-stimulating factor in patients with prolonged neutropenia after adjuvant chemotherapy of breast cancer is a safe and cost-effective schedule to maintain dose-intensity". J. Clin. Oncol., 1996, 14, 1573.
[28] Lyman G. H., Kuderer N. M., Djulbegovic B.: "Prophylactic granulocyte colony-stimulating factor in patients receiving doseintensive cancer chemotherapy: a meta-analysis". Am. J. Med., 2002, 112, 406.
[29] Croockewit A. J., Bronchud M. H., Aapro M. S., Bargetzi M. J., Crown J., Gratwohl A. et al.: "A European perspective on haematopoietic growth factors in haemato-oncology: report of an expert meeting of the EORTC". Eur. J. Cancer, 1997, 33, 1732.
[30] Balducci L., Yates J.: "General guidelines for the management of older patients with cancer". Oncology, 2000, 14, 221.
[31] Lyman G. H., Kuderer N., Greene J., Balducci L.:'The economics of febrile neutropenia: implications for the use of colony-sti-mulating factors". Eur. J. Cancer, 1998, 34, 1857.
[32] Sivasubramaniam V.,D ale D.,C rawford J.,A gboola Y.,L yman G.: "Impact of outpatient treatment of febrile neutropenia (FN) on risk thresholds for G-CSF prophylaxis in cancer chemotherapy". Proc. Am. Soc. Clin. Oncol., 2001, 20, 392a. Abstract 1563
[33] Bennett C. L., Weeks J. A., Somerfield M. R., Feinglass J., Smith T. J.: "Use of hematopoietic colony-stimulating factors; comparison of the 1994 and 1997 American Society of Clinical Oncology surveys regarding ASCO clinical practice guidelines". J Clin. Oncol., 1999, 17, 3676.
[34] Balducci L., Hardy C. L., Lyman G. H.: "Hemopoietic reserve in the older cancer patient: clinical and economic considerations" Cancer Control, 2000, 7, 539.
[35] Silber J. H., Fridman M., DiPaola R. S., Erder M., Pauly M., Fox K.: "First-cycle blood counts and subsequent neutropenia, dose reduction or delay in early-stage breast cancer therapy". J. Clin. Oncol., 1998, 16, 2392.
[36] Aslani A., Smith R., Allen B., Pavlakis N., Levi J.: "The predictive value of body protein for chemotherapy-induced toxicity" Cancer, 2000, 15, 796.
[37] Lininger L., Crawford J., Dale D., Chen H., Agboola Y., Stump E. et al.: "Predicting risk of neutropenic complications: a pointof-care assessment tool". Proc. Am. Soc. Clin. Oncol., 2001, 20, 411a (Abstract 1640).
[38] Lyman G. H., Crawford J., Dale D., Chen H., Agboola Y., Lininger L.: "Clinical prediction models for febrile neutropenia (FN) and relative dose intensity (RDI) in patients receiving adjuvant breast cancer chemotherapy". Proc. Am. Soc. Clin. Oneal., 2001, 20, 394a (Abstract 1571)
[39] Dees E. C., O'Reilly S., Goodman S. N., Sartorius S., Levine M. A., Jones R. J. et al.: "A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer". Cancer Invest., 2000, 18, 521.
[40] Begg C. B., Elson P. J., Carbone P. P.: "A study of excess hematologic toxicity in elderly patients treated on cancer chemotherapy protocols". In: "Cancer in the elderly; approaches to early detection and treatment". New York, Springer, 1989, 149.
[41] Chatta G. S., Price T. H., Stratton J. R., Dale D. C.: "Aging and marrow neutrophil reserves". J. Am. Geriatr. Soc., 1994, 42, 77.
[42] Bokemeyer C., Honecker F., Wedding U., Spath-Schwalbe E., Lipp H.P., Kolb G.: "Use ofhematopoietic growth factors in elderly patients receiving cytotoxic chemotherapy". Onkologie,2002, 25, 32.
[43] Molineux G., Kinstler O., Briddell B., Hartley C., McElroy P., Kerzic P. et al.: "A new form of filgrastim with sustained duration in vivo and enhanced ability to mobilise PBPC in both mice and humans". Exp. Hematol., 1999, 27, 1724.
[44] Holmes F. A., Jones S. E., O'Shaughnessy J., Yukelja S., George T., Savin M. et al.: "Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer". Ann. Oneal., 2002, 13, 903.
[45] Bedell C.: "Pegfilgrastim for chemotherapy-induced neutropenia". Clin. J. Oneal. Nurs., 2003, 7, 55.
[46] Holmes F. A., O'Shaughnessy J. A., Yukelja S., Jones S. E., Shogan J., Savin M. et al.: "Blinded, randomized, multicenter study to evaluate single administration pegfilgrastim once per cycle versus daily filgrastim as an adjunct to chemotherapy in patients with high-risk stage II or stage III/IV breast cancer". J. Clin. Oneal., 2002, 20, 727.
[47] Green M. D., Koelbl H., Baselga J., Galid A., Guillem Y., Gascon P. et al.: "A randomized, double-blind, phase 3 study of fixeddose, single-administration pegfilgrastim vs daily filgrastim in patients receiving myelosuppressive chemotherapy". Ann. Oncol., 2003, 14, 29.
[48] Misset J. L., Dieras Y., Gruia G., Bourgeois H., Cvitkoic E., Kalla S. et al.: "Dose-finding study of docetaxel and doxorubicin in first-line treatment of patients with metastatic breast cancer". Ann. Oneal., 1999, 10, 553.
[49] Siena S., Piccart M. J., Holmes F. A., Glaspy J., Hackett J., Renwick J.: "A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily fi lgrastim in patients with stage II-IV breast cancer". Oneal. Rep., 2003, 10, 715.
[50] Pettengell R.: "Advances in haematological support of cancer treatments". Eur. J. Hosp. Pharm., 2002, 2, 56.
[51] Groopman J. E., Itri L. M.: "Chemotherapy-induced anemia in adults; incidence and treatment". J. Natl. Cancer Inst., 1999, 91, 1616.
[52] Skillings J. R., Rogers-Melamed I., Nabholtz J.-M., Sawka G., Gwardry-Sridhar P., Moquin J.-P. et al.: "An epidemiological review of anaemia in cancer chemotherapy in Canada". Eur. J. Cancer, 1995, 31a (suppl. 5), S5 (Abstract 879)
[53] O'Shaughnessy J., Vukelja S., Savin M., Holmes F. A., Jones M., Royall D. et al.: "Effects of epoetin alfa (Procrit) on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant or neoadjuvant chemotherapy: a double-blind, randomised, placebo-controlled trial". Proc. Am. Soc. Clin. Oneal., 2002, 21, 363a (Abstract 1449).
[54] Demetri G. D., Gabrilove J. L., Blasi M. Y., Hill R. J., Glaspy J.: "Benefits of epoetin alfa in anemic breast cancer patients receiving chemotherapy". Clin. Breast Cancer, 2002, 3, 45.
[55] Vogelzang N. J., Breitbart W., Cella D., Curt G. A., Groopman J. E., Horning S. J. et al.: "Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey". Semin. Hematol., 1997, 34 (suppl. 2), 4.
[56] Cella D.: "The functional assessment of cancer therapy-anemia (FACT-An) scale: a new tool for the assessment of outcomes in cancer anemia and fatigue". Semin. Hematol., 1997, 34 (suppl. 2),13.
[57] Caro J. J., Salas M., Ward A., Goss G.: "Anemia as an independent prognostic factor for survival in patient with cancer: a systematic, quantitative review". Cancer, 2001, 91, 2214.
[58] Frommhold H., Guttenberger R., Henke M.: "The impact of blood haemoglobin content on the outcome of radiotherapy. T he Freiburg experience". Strahlenther. Onkol., 1998, 174 (suppl. 4), 31.
[59] Littlewood T. J., Bajetta E., Nortier J. W., Vercammen E., Rapoport B.: "Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results or a randomised, double-blind, placebo-controlled trial". J. Clin. Oneal., 2001, 19, 2865.
[60] Lawless G., Royalty M. W., Meyers J.: "Epoetin practice pattern usage in community practice". Blood, 2000, 96, 390b (Abstract 5446).
[61] ISIS. Research conducted by ISIS Research Ltd. 2000. Data on file.
[62] Koeller J.: "Clinical guidelines for the treatment of cancer-related anaemia". Pharmacother, 1998, 18, 156.
[63] Demetri G. D.: "Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy". Br. J. Cancer, 2001, 84 (suppl. ]), 31.
[64] Elliott S. G., Lorenzini T., Strickland T., Delorme E., Egrie J. C.: "Rational design of novel erythropoiesis stimulating protein (Aranesp™): a super-sialyted molecule with increased biological activity". Blood, 2000, 96, 82a. Abstract 352.
[65] Egrie J. C., Browne J. K.: "Development and characterization of novel erythropoiesis stimulating protein (NESP)". Br. J. Cancer, 2001, 84 (suppl.1), 3.
[66] Heatherington A., Schuller J., Dittrich C., Mercer A. J., Rossi G.: "Intravenous (IV) administration of darbepoetin alfa to patients with nonmyeloid malignancies receiving multicycle chemotherapy; pharmacokinetic profiles". Proc. Am. Soc. Clin. Oncol., 2002, 21, 256b (Abstract 2844).
[67] Macdougall I. C., Gray S. J., Elston O., Breen C., Jenkins B., Browne J. et al.: "Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients". J. Am. Soc. Nephrol., 1999, 10, 2392.
[68] Glaspy J. A., Jadeja J. S., Justice G., Kessler J., Richards D., Schwartzberg L. et al.: "Darbepoetin alfa given every I or 2 weeks alleviates anaemia associated with cancer chemotherapy". Br. J. Cancer, 2002, 87, 268.
[69] Glaspy J. A., Tchekmedyian N. S.: "Darbepoetin alfa administered every 2 weeks alleviates anemia in cancer patients receivmg chemotherapy". Oncology, 2002, 16 (suppl. 11), 23.
[70] Hedenus M., Hansen S., Taylor K., Arthur C., Emmerich B., Dewey C. et al.: "Randomized, dose-finding study of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies". Br. J. Haematol., 2002, 119, 79.
[71] Vansteenkiste J., Pirker R., Massuti B., Barata F., Font A., Fiegl M. et al.: "Double-blind, placebo-controlled, randomized phase III trial of darbepoetin alfa in lung cancer patients receiving cancer chemotherapy". J. Natl. Cancer Inst., 2002, 94, 1211.
[72] Kotasek D., Albertsson M., Mackey J., Berg R., Robinson J., Colowick A.: "Randomized, double-blind, placebo-controlled, dosefinding study of darbepoetin alfa administered once every 3 (Q3W) or 4 (Q4W) weeks in patients with solid tumours". Proc. Am Soc. Clin. Oneal., 2002, 21, 356a (Abstract 1421).
[73] Smith R. E., Tchekmedyian S., Richards D., Klamet J., Fleishman A., Gayko U. et al.: "Darbepoetin alfa effectively alleviates anemia in patients with chronic anemia of cancer; efficacy and pharmacokinetic results of a doseescalation study". Proc. Am. Soc Clin. Oncol., 2002, 21, 367a (Abstract 1465).
[74] Kallich J., Erder H., Glaspy J., Vansteenkiste.T., Rossi G., Poulsen E. et al.: "Improvement in haemoglobin levels improves healthrelated quality of life (HRQOL) of anaemic cancer patients". Hematol. J., 2001, 1 (suppl. 1), 185 (Abstract 688).
[75] Glaspy J., Jadeha J., Justice G., Fleishman A., Armstrong S., Colowick A.: "Optimizing the management of anemia in cancer patients: a randomised, active-controlled, study investigating the dosing of darbepoetin alfa". Proc. Am. Soc. Clin. Oncol., 2002, 21, 362a (Abstract 1446).
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Top