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Cancer of the cervix with endometrial extension treated by radiotherapy: A retrospective case-control study

  • F. L. Ampil1,*,
  • G. Caldito2
  • J.B. Unger3

1Departments of Radiology, USA

2Departments of Biometry, USA

3Departments of Obstetrics-Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

DOI: 10.12892/ejgo200305362 Vol.24,Issue 5,September 2003 pp.362-364

Published: 10 September 2003

*Corresponding Author(s): F. L. Ampil E-mail:

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Abstract

Background: Studies determining prognosis of cancer of the cervix with endometrial extension (CCEE) in a case-control fashion are scant.

Methods: A case-control retrospective study of 20 women with CCEE and 16 patients with cervical cancer not extending to the endometrium (CCNEE) treated by radiation was undertaken. The patient groups were matched for age, disease stage, the presence of bulky/barrel-shaped tumor in the cervix, intercurrent illness, total radiation dose, and hemoglobin level. The overall mean follow-up was 54 months (range 8 to 218 months).

Results: The numerical rates of local and systemic failure as well as 5-year survival were worse for patients with CCEE versus CCNEE. However, the observed differences were not statistically significant.

Conclusion: Involvement of the endometrium by cancer of the cervix seems to confer a worse outcome among cervical cancer patients treated by radiation alone.

Keywords

Cancer of the cervix; Endometrial extension; Radiotherapy

Cite and Share

F. L. Ampil,G. Caldito,J.B. Unger. Cancer of the cervix with endometrial extension treated by radiotherapy: A retrospective case-control study. European Journal of Gynaecological Oncology. 2003. 24(5);362-364.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200305362

References

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[2] Perez C.A., Camel H.M., Askin F.. Breaux S.: "Endometrial extension of carcinoma of the uterine cervix: a prognostic factor that may modify staging". Cancer, 1981, 48, 170.

[3] Spanos W.J., Greer B.E., Hamberger A.D., Rutledge F.N.: "Prognosis of squamous cell carcinoma of the cervix with endometrial involvement". Gynecol. Oncol., 1981, 11, 230.

[4] Prempree T., Patanaphan V., Viravathana T., Sewchand W., Cho Y.K., Scott R.M.: "Radiation treatment of carcinoma of the cervix with extension into the endometrium. A reappraisal of its significance". Cancer, 1982, 49, 2015.

[5] Bell M.C., Davidson S.A., Mathis M., Ampil F.: "Topotecan concomitant with primary brachytherapy radiation in patients with cervical carcinoma: A phase I trial". Gynecol. Oncol., 2001, 80, 128.

[6] American Joint Committee on Cancer Staging Manual: "Cervix Uteri". 2002 (6'" ed.), 259.

[7] Ampil F.L., Bell M.C.: "Aggressive radiotherapy for stage lllB cancer of the cervix: helpful or harmful?". Acta Obstet. Gynecol. Scand., 1998, 77, 350.

[8] Hanks G.E., Herring D.F., Kramer S.: "Patterns of care outcome studies: results of the national practice in cancer of the cervix" Cancer, 1983, 51, 959.

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