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Case Reports

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Uterine sarcoma associated with tamoxifen use: Case report

  • M. Martin-Loeches1,*,
  • J. Rius1
  • R. M. Orti2

1Department of Gynaecology. "Marina Alta" University Hospital, Alicante, Spain

2Department of Preventive Medicine. University Hospital Clinic, Valencia, Spain

DOI: 10.12892/ejgo200302202 Vol.24,Issue 2,March 2003 pp.202-203

Published: 10 March 2003

*Corresponding Author(s): M. Martin-Loeches E-mail:

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Abstract

A case of müllerian adenosarcoma with sarcomatous overgrowth in a postmenopausal 66-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The patient was asymptomatic and the neoplasm was detected by pelvic sonography. The diagnosis was based on the histological findings after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.


Keywords

Uterine adenosarcoma; Breast cancer; Tamoxifen; Uterine sarcoma

Cite and Share

M. Martin-Loeches,J. Rius,R. M. Orti. Uterine sarcoma associated with tamoxifen use: Case report. European Journal of Gynaecological Oncology. 2003. 24(2);202-203.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200302202

References

[1] Le Bouedec G., Auvray H., Cure H. et al.: "Uterine sarcoma in patients receiving tamoxifen therapy. Apropos of 2 cases". Rev. Med. Inter., 2001, 22, 881.

[2] Wickerham D. L., F isher B., Wolmark N. et al.: "Association of tamoxifen and uterine sarcoma". J. Clin. Oneal., 2002, 20, 2758.

[3] Barakat R.R.: "Tamoxifen and the endometrium". Cancer Treat. Res., 1998, 94, 195.

[4] Ismail S. M.: "Pathology of endometrium treated with tamoxifen". J. Clin. Pathol., 1994, 47, 827.

[5] Liao J.B., Lin J. Y.: "Estrogen receptor expression in an endometrial stromal sarcoma after tamoxifen therapy". Eur. J. Gynaecol. Oneal., 2001, 22, 417.

[6] Carvalho F. M., Carvalho J.P., Motta E. V., Souen J.: "Miillerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer". Rev. Hosp. Clin. Fae. Med. Sao Paulo, 2000, 55, 17.

[7] Mourits M. J., De V ries E.G., Willemse P.H., Ten Hoor K. A., Hollema H., Van der Zee A.G.: "Tamoxifen treatment and gynecologic side effects: a review". Anticancer Res., 2000, 20, 2015.

[8] Seoud M.A., Johnson J., Weed J.C. Jr.: "Gynecologic tumors in tamoxifen-treated women with breast cancer". Obstet. Gynecol., 1993, 82, 165.

[9] Fotiou S., Hatjieleftheriou G., Kyrousis G., Kokka F., Apostolikas N.: "Long-term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case-reports and review of the literature". Anticancer Res., 2000, 20, 2015.

[10] Olah K. S.: "Uterine carcinosarcoma in association with tamoxi- i fen therapy". Br. J. Obstet. Gynaecol., 1997, 104, 1420.

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