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Chlamydia trachomatis infection in women with CIN and invasive uterine cervix cancer. Significance of hormonal status

  • J. Markowska1,*,
  • N. Fischer2
  • Z. Fischer2
  • J.B. Warchol3

1Chair of Oncology, Poland

2Departments of Gynecology and Obstetrics, Holy Family Clime, Poland

3Chair of Radiology and Biology Faculty of Medicine, K.Marcinkowski University School of Medicine, Poznan, Poland

DOI: 10.12892/ejgo200206511 Vol.23,Issue 6,November 2002 pp.511-513

Published: 10 November 2002

*Corresponding Author(s): J. Markowska E-mail:

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Abstract

In women with CIN at fertile age and those over 50 years of age, EGFR expression is lower in the presence of Chlamydia trachomatis (Cht) infection. In all Cht infected women over 50 years of age expression of Ki 67 is higher; the increase is significant among women with invasive carcinoma. In these groups of women with CIN and invasive carcinoma TGF-alpha expression is insignificantly augmented. Chronic Cht infection is associated with cervical hypertrophy.

Keywords

Cht infection; CIN; Cervical cancer; Hormonal status

Cite and Share

J. Markowska,N. Fischer,Z. Fischer,J.B. Warchol. Chlamydia trachomatis infection in women with CIN and invasive uterine cervix cancer. Significance of hormonal status. European Journal of Gynaecological Oncology. 2002. 23(6);511-513.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200206511

References

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[7] Markowska J., Fischer N., Filas V., et al.: "The role of Chlamydia trachomatis infection in cervical cancer development". Eur. J. Gynaecol. Oneal., 1999, 20 (2), 144.

[8] Puolakkainen M., Vesterinen E., Purola E., et al.: "Persistence of chlamydia] antibodies after pelvic inflammatory disease". J. Clin Microbial., 1986, 23, 924.

[9] Suchet H.: "Hormonal contraception and pelvic inflammatory disease". Ew: J. Contracept. Reprod. Health Care, 1997, 4, 267.

[10] Wallin K. L., Wiklund F., Angstrom T., et al.:'Type-specific persistence of human papilloma virus DNA before the development of invasive cervical cancer". N. Engl. J. Med., 1999, 341, 1633.

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