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Ovarian fibrosarcoma with five-year survival: a case report

  • L. Cinel1,*,
  • D. Taner2
  • S. B. Nabaei2
  • S. Oguz3
  • O. Gokmen3

1Department of Pathology, Medical School of Mersin University, Mersin, Turkey

2Department of Pathology, Dr. ZTB Woman Hospital, Ankara, Turkey

3Department of Obstetrics and Gynaecology, Dr. ZTB Woman Hospital, Ankara, Turkey

DOI: 10.12892/ejgo200204345 Vol.23,Issue 4,July 2002 pp.345-346

Published: 10 July 2002

*Corresponding Author(s): L. Cinel E-mail:

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Abstract

A 45-year-old postmenopausal woman, Gravida6, Para4, Abortus0, Dilatation x Curhetage2, came to the gynaecology department with pelvic pain. The tumor had arisen in the right ovary and measured 15 x 12 x 7 cm. Its cut surface varied from grey-white with a whorled appearance and showed areas of haemorrhage. Histologically the tumor was densely cellular, composed of spindle cells, diffusely involved the entire ovarian stroma with no normal ovarian structures remaining. Tumor cells had hyperchromatic nuclei with prominent nucleoli. There was moderate pleomorphism and the number of mitotic figures was an average of 6 per 10 high power fields. In the immunohistochemical study, the tumor was negative for desmin, muscle-specific actin, estrogen, progesterone receptors and CD31, but was positive for vimentin. A low proliferation index with Ki-67 was determined. The patient has shown no evidence of recurrent disease for five years.

Keywords

Sarcoma; Fibrosarcoma; Ovary

Cite and Share

L. Cinel,D. Taner,S. B. Nabaei,S. Oguz,O. Gokmen. Ovarian fibrosarcoma with five-year survival: a case report. European Journal of Gynaecological Oncology. 2002. 23(4);345-346.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200204345

References

[1] Talerman A.: " Nonspecific tumors of the ovary, includmg mesenchymal tumors and malignant lymphoma". In: Kurman R. (ed.), Blaustein's Pathology of the Female G enital Tract 4'" ed., New York, Springer-Verlag Press, 1994, 915.

[2] Tsuji T., Kawauchi S., Utsunomiya T., Nagata Y. Tsuneyoshi M. "Fibrosarcoma versus cellular fibroma of the ovary. A comparative study of their proliferative activity and chromosome aberrations using MIB-1 immunostaining, DNA flow cytometry. 叩d Fluorescence in situ hybridisation". Am. J. Surg. Path., 1997, 21 (1), 52.

[3] Kraemer B. B., Silva E.G., Sneige N.: "Fibrosarcoma of ovary. A new component in the nevoid basal-cell carcinoma syndome". Am J. Surg. Path., 1984, 8(3), 231.

[4] Huang Y. C., Hsu K. F., Chou C. Y., Dai Y. C., Tzeng C. C.: "Ovarian fibrosarcoma with long term survival: a case report". Int J. Gyneacol. Cancer, 2001, 11 (4), 331.

[5] Prat J., Scully R. E.: "Cellular fibromas and fibrosarcomas of the ovary. A comparative clinicopathologic analysis of 17 cases" Cancer, 1982, 47, 2663.

[6] Miles P.A., Kiley K. C., Mena H.: "Giant fibrosarcoma of the OVary". Internal. J. Gynecol. Path., 1985, 4 (1), 83.

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