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Hypersensitivity reaction to carboplatin: successful resolution by replacement with cisplatin

  • G. Porzio1,*,
  • P. Marchetti1
  • I. Paris1
  • F. Narducci1
  • E. Ricevuto1
  • C. Ficorella1

1Medical Oncology Unit, University of L'Aquila, Italy

DOI: 10.12892/ejgo200204335 Vol.23,Issue 4,July 2002 pp.335-336

Published: 10 July 2002

*Corresponding Author(s): G. Porzio E-mail:

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Abstract

Hypersensitivity reactions caused by carboplatin rarely occur. These reactions can cause lethal complications and make subsequent therapeutic approaches difficult. To date, only a few cases of successful resolution of hypersensitivity by replacement of carboplatin with cisplatin have been reported. We report on a patient with serous papillary extra-ovarian peritoneal carcinoma who developed a hypersensitivity reaction after the 10th weekly administration of carboplatin. Two weeks after reaction, intradermal skin testing with paclitaxel, carboplatin, cisplatin, and mannitol showed intense reaction only to carboplatin. On the basis of these results, the patient was changed to a chemotherapy with cisplatin and paclitaxel. A further eight courses of chemotherapy were administered without evidence of hypersensitivity reactions. Carboplatin seems to be successfully replaceable by cisplatin in case of hypersensitivity reactions.


Keywords

Carboplatin; Hypersensitivity; Cisplatin replacement

Cite and Share

G. Porzio,P. Marchetti,I. Paris,F. Narducci,E. Ricevuto,C. Ficorella. Hypersensitivity reaction to carboplatin: successful resolution by replacement with cisplatin. European Journal of Gynaecological Oncology. 2002. 23(4);335-336.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200204335

References

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[7] Broome C. B., Schiff R. I., Friedman H. S.:''Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions". Med. Pediatr. Oncol., 1996, 26, 105.

[8] Kook H., Kim R. M., Choi S. H. et al.: "Life-treatening carboplatin hypersensitivity during conditioning for autologous PBSC transplantation: Successful rechallenge after desensitization". Bone Marrow Transplant, 1998, 21, 727,

[9] Zanotti K. M., Rybicki LA., Kennedy A. W. et al.: "Carboplatm skin testing: a skin-testing protocol for predicting hipersensitivity to carboplatin chemotherapy". J. Clin. Oneal., 2001, 19, 3126.

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