Article Menu

Export Article

More by Authors Links

Article Data

  • Views 217
  • Dowloads 144

Case Reports

Open Access

Hypersensitivity reaction to carboplatin: successful resolution by replacement with cisplatin

  • G. Porzio1,*,
  • P. Marchetti1
  • I. Paris1
  • F. Narducci1
  • E. Ricevuto1
  • C. Ficorella1

1Medical Oncology Unit, University of L'Aquila, Italy

DOI: 10.12892/ejgo200204335 Vol.23,Issue 4,July 2002 pp.335-336

Published: 10 July 2002

*Corresponding Author(s): G. Porzio E-mail:

PDF (207.31 kB)

Abstract

Hypersensitivity reactions caused by carboplatin rarely occur. These reactions can cause lethal complications and make subsequent therapeutic approaches difficult. To date, only a few cases of successful resolution of hypersensitivity by replacement of carboplatin with cisplatin have been reported. We report on a patient with serous papillary extra-ovarian peritoneal carcinoma who developed a hypersensitivity reaction after the 10th weekly administration of carboplatin. Two weeks after reaction, intradermal skin testing with paclitaxel, carboplatin, cisplatin, and mannitol showed intense reaction only to carboplatin. On the basis of these results, the patient was changed to a chemotherapy with cisplatin and paclitaxel. A further eight courses of chemotherapy were administered without evidence of hypersensitivity reactions. Carboplatin seems to be successfully replaceable by cisplatin in case of hypersensitivity reactions.


Keywords

Carboplatin; Hypersensitivity; Cisplatin replacement

Cite and Share

G. Porzio,P. Marchetti,I. Paris,F. Narducci,E. Ricevuto,C. Ficorella. Hypersensitivity reaction to carboplatin: successful resolution by replacement with cisplatin. European Journal of Gynaecological Oncology. 2002. 23(4);335-336.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200204335

References

[I] Shukunami K., Kurokawa T., Kawakami Y., Kubo M., Kotsuji F.: "Hypersensitivity reactions to intraperitoneal administration of carboplatin to ovarian cancer: the first report of a case". Gynecol Oneal., 1999, 72, 431.

[2] Rose P. G., Fusco N., Fluellen L. et al.: "Carboplatin hypersensitivity rea(,tions in patients with ovarian and peritoneal carcinoma" Int. J. Gynecol. Cancer, 1998, R, 365.

[3] Markman M., Kennedy A., Webster K. et al.: "Clinical features of hypersensitivity reactions to carboplatin". J. Clin. Oncol., 1999, 17, 1141.

[4] Hendrick A. M., Simmons D., Cantwell B. M.J.: "Allergic reaction to carboplatin". Ann. Oncol., 1992, 3, 239.

[5] Wiedmann B., Mulleneisen N., Bojko P;, Neiderle N.: "Hypersensitivity reactions to carboplatin". Cancer, 1994, 73, 2218.

[6] Shukunami K., Kurosawa T., Kubo M., Kaneshima M., Kamitani N., Kotsuji F: "Hypersensitivity reaction to carboplati? during treatment for ovarian cancer: successful resolution by replacement with cisplatin". Tumori, 1999, 85, 297.

[7] Broome C. B., Schiff R. I., Friedman H. S.:''Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions". Med. Pediatr. Oncol., 1996, 26, 105.

[8] Kook H., Kim R. M., Choi S. H. et al.: "Life-treatening carboplatin hypersensitivity during conditioning for autologous PBSC transplantation: Successful rechallenge after desensitization". Bone Marrow Transplant, 1998, 21, 727,

[9] Zanotti K. M., Rybicki LA., Kennedy A. W. et al.: "Carboplatm skin testing: a skin-testing protocol for predicting hipersensitivity to carboplatin chemotherapy". J. Clin. Oneal., 2001, 19, 3126.

[10] Shelback A. A., Clark P. I., Green J. A.: "Hypersensitivity and cross-reactivity to cisplatin and analogues". Cancer Chemother. Pharmacol., 1995, 35, 349.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top