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Original Research

Open Access

Is there a link between vulval cancer and blood group?

  • K. J. Rolfe1
  • J. J. Nieto1,*,
  • W. M. N. Reid1
  • C. W. Perrett1
  • A. B MacLean1

1University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, London, UK

DOI: 10.12892/ejgo200202111 Vol.23,Issue 2,March 2002 pp.111-112

Published: 10 March 2002

*Corresponding Author(s): J. J. Nieto E-mail:

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Abstract

Risk factors for squamous cell vulval cancer (SCC) remain unclear though there have been associations with lichen sclerosis, smoking, and vulval intraepithelial neoplasia (VIN). We studied 191 patients who had been referred to the vulval clinic at the Royal Free Hospital and who had both blood group and histopathology results available. Seventy-two percent of patients with SCC and non-neoplastic epithelial disorders of the vulva (NNEDV) were found to be in blood group A with only 17% in blood group O. Those with SCC associated with VIN had only 30% in blood group A with 50% in blood group O. The control population showed that 38% of the population were in blood group A and 43% were in blood group O. Our results suggest that blood group A is prevalent in patients with SCC associated with NNEDV but not in those women with squamous vulval cancer and associated VIN.

Keywords

Lichen sclerosus; VIN; Yulval cancer; Blood groups; Progression

Cite and Share

K. J. Rolfe,J. J. Nieto,W. M. N. Reid,C. W. Perrett,A. B MacLean. Is there a link between vulval cancer and blood group?. European Journal of Gynaecological Oncology. 2002. 23(2);111-112.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200202111

References

[1] Bloss J. D., Liao S. Y., Wilczynski S. P., Macri C., Walker J., Peake M., Berman M. L.: "Clinical and histologic features of vulvar carcinomas analyzed for human papillomavirus status: evidence that squamous cell carcinoma of the vulva has more than one etiology". Hum. Pathol., 1991, 22, 711。

[2] Aird I., Bentall H. H., Fraser Roberts J. A.: "A relationship between cancer of the stomach and the ABO blood groups". Br. Med. J., 1953, 1, 799.

[3] Henderson J., Seagrott V., Goldacre M.: "Ovarian cancer and ABO blood groups". J. Epidemiol. Community Health, 1993, 47, 287.

[4] Race R.R., Sanger R.: "Blood Groups in Man". London, Blackwell. 1979.

[5] Leighton P. C., Langley F. A.: "A Clinico-pathological study of vulval dermatoses". J. Clin. Pathol., 1975, 28, 394.

[6] Andersen W. A., Franquemont D. W., William J. et al.: "Vulvar squamous cell carcinoma and papillomaviruses: two separate entities?”.Am. J. Obstet. Gynecol., 1991, 165, 329.

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