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Extramammary Paget's disease found by abnormal vul var brush sampling

  • B. K. J. Yu1,*,
  • C. R. Lai2
  • M. S. Yen1
  • N. F. Tou1
  • K. C. Chao1
  • C. C. Yuan1

1Department of Obstetrics and Gynecology, Taiwan

2Department of Pathology, Taipei Veterans General Hospital, National Yang-Ming University, National Defense Medical Center, Taipei, Taiwan

DOI: 10.12892/ejgo20020135 Vol.23,Issue 1,January 2002 pp.35-36

Published: 10 January 2002

*Corresponding Author(s): B. K. J. Yu E-mail:

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Abstract

Introduction: Doctors are usually reluctant to perform a vulvar biopsy on a patient with non-specific chronic vulvitis--especially because of the rarity of vulvar malignancy in young women--until the lesion is suspected of being malignant. Therefore, most cases of extramammary Paget's disease (EMPD) were originally misdiagnosed as chronic and recurrent vulvar lesions. Late diagnosis of invasive lesions occurring in elderly females have resulted in cases of death.

Case: A 37-year-old patient showed an extended lesion on the vulva and perineum. In addition, abnormal cells were found from a vulvar scrape smear, and a following punch biopsy was used to diagnose and determine the extension of the disease.

Conclusion: Diagnosis and demarcation of EMPD remain difficult due to the multifocal lesions and subtle nature of the disease. Brush sampling taken from suspicious areas can be a guide for multiple biopsies to demarcate the lesion before major surgery. A brush biopsy is presented as a first-step method to detect vulvar malignancy.

Keywords

Extramammary Paget's disease; Tissue sampling; Cancer screening

Cite and Share

B. K. J. Yu,C. R. Lai,M. S. Yen,N. F. Tou,K. C. Chao,C. C. Yuan. Extramammary Paget's disease found by abnormal vul var brush sampling. European Journal of Gynaecological Oncology. 2002. 23(1);35-36.

URL:

https://www.ejgo.net/articles/10.12892/ejgo20020135

References

[1] Wilkinson E. J.: "Normal histology and nomenclature of the vulva, and malignant neoplasms, including VIN". Derm. Clinics., 1992, 10, 283.

[2] Kurzl R. G.: "Paget's disease". Semin. Derm., 1996, 15, 60.

[3] Gunn R. A., Gallager H. S.: "Vulvar Paget's disease- a topographic study". Cancer, 1980, 46, 590.

[4] DiSaia P. J., Creasman W. T.: "Clinical gynecologic oncology. Invasive cancer of the vulva". In: "Paget's Disease" (eds.): DiSaia P. J., Creasman W. T. Mi、souri: Mosby-Year Book, Inc. 1997, 222.

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