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Treatment of metastatic invasive moles in two husband-side sisters-in-law. Case reports and review of literature

  • M.A. van Eijkeren1,*,
  • E. A. Sijmons1
  • P. O. Witteveen2
  • M. J. Verhaar2
  • D. M. D.S. Sie-Go3
  • A. P. M. Heintz1

1Department of Obstetrics and Gynecology, The Netherlands

2Department of Internal Medicine, Medical Oncology Section, The Netherlands

3Department of Pathology, University Medical Center, Utrecht, The Netherlands

DOI: 10.12892/ejgo200106406 Vol.22,Issue 6,November 2001 pp.406-408

Published: 10 November 2001

*Corresponding Author(s): M.A. van Eijkeren E-mail:

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Abstract

Purpose of investigation: The treatment of "high risk" persistent trophoblastic disease (PTD) consists of poly-chemotherapy. This policy probably will lead to overtreatment of some patients. Also, familiar molar pregnancies through the paternal line are unknown in the literature up till now.

Methods: We describe two cases of "high risk" PTD in two husband-side sisters-in-law, in which poly-chemotherapy was stopped after histology became available and showed invasive metastatic mole.

Conclusion: It should be stressed that treatment decisions should be made based on the concept of "high" or "low" risk PTD, but if histology becomes available, chemotherapy might be less aggressive in cases of invasive mole. If invasive mole could be familiar through the paternal line remains unclear with the current knowledge of genetics in trophoblastic disease.

Keywords

Persistent trophoblastic disease; Metastatic invasive mole; Familiar invasive mole

Cite and Share

M.A. van Eijkeren,E. A. Sijmons,P. O. Witteveen,M. J. Verhaar,D. M. D.S. Sie-Go,A. P. M. Heintz. Treatment of metastatic invasive moles in two husband-side sisters-in-law. Case reports and review of literature. European Journal of Gynaecological Oncology. 2001. 22(6);406-408.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200106406

References

[1] Lewis J.: "Diagnosis and management of gestational trophoblastic disease". Cancer, 1993, 71, 1639.

[2] Kajii T., Ohama K.: "Androgenetic origin of hydatidiform mole" Nature, 1977, 268, 633.

[3] Ring A. M.: "The concept of benign metastasizing hydatidiform moles". Am. J. Clin. Path., 1972, 58, 111.

[4] Lurain J. R., Brewer J. I.: "Invasive mole". Semin. Oneal., 1982, 9, 174.

[5] Bagshawe K. D., Dent J., Webb J.: "Hydatidiform mole in the United Kingdom 1973 - 1983". Lancet, 1986, ii, 673.

[6] Rustin G. J. S.,B ooth M.. Dent J.: "Pregnancy after cytotoxic chemotherapy for gestational trophoblastic tumours". Br. Med. J.. 1984, 288, 103.

[7] Okamoto T.,N omura S.,N akanishi T.,G oto S.,T omoda Y.,M 1zutani M.: "Choriocarcinoma diagnostic score: a scoring system to differentiate choriocarcinoma from invasive mole". In t. J. Gynecol. Cancer, 1998, 8, 128.

[8] Fulop V., Colitti C. V., Genest D.,B erkowitz R. S.,Y iu G. K.. Ng S., Szepesi J., Mok S. M.: "DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic disease". Oncogene, 1998, 17, 419.

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