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A ten-year remission maintained by 6272 mg (3920 mg/m2) cumulative dose of cisplatin-based chemotherapy for recurrent epithelial ovarian cancer

  • M. Steven Piver1,*,

1Sisters of Charity Hospital, Buffalo NY, USA

DOI: 10.12892/ejgo200106403 Vol.22,Issue 6,November 2001 pp.403-405

Published: 10 November 2001

*Corresponding Author(s): M. Steven Piver E-mail:

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Abstract

Since cisplatin is a heavy metal, renal and neurotoxicity is considered to be dose limiting in solid tumors. The current case is unusual in that remission has been maintained in a patient with recurrent epithelial ovarian cancer by cisplatin-based chemotherapy without evidence of renal or neurotoxicity, while receiving a total dose of 6,270 mg (3,920 mg/m2) of cisplatin over 11 1/2 years.

Keywords

Chemotherapy; Cisplatin; Ovarian cancer

Cite and Share

M. Steven Piver. A ten-year remission maintained by 6272 mg (3920 mg/m2) cumulative dose of cisplatin-based chemotherapy for recurrent epithelial ovarian cancer . European Journal of Gynaecological Oncology. 2001. 22(6);403-405.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200106403

References

[1] PiverM . S., Lele S. B.,P atsner B.M, cPheeM . E.; "1.5 - 5 years of uninterrupted cis-diamminedichloroplatinum II chemotherapy for metastatic cervical cancer". Gynecol. Oneal., 1987, 27, 24.

[2] Sutton G. P., Tehman F. B., Einhorn L. H. et al.: "Ten year followup of patients receiving cisplatin, doxarubicin, and cyclophospha-mide chemotherapy for advanced epithelial ovarian cancer". J. Clin. Oncol., 1989, 7, 223.

[3] Eltabbakh D. H., Hempling R., PiverM . S., Recio F. O., Blumenson L. E.: "Prolonged disease-free survival by maintenance chemotherapy among patients with recurrent platinum-sensitive ovarian cancer". Gyn. Oneal., 1998, 71,190.

[4] PiverM . S., Lele S. B., Marchetti D. L. et al.:'The impact of aggessive debulking surgery and cisplatin-based chemotherapy on progression free survival in stage III and IV ovarian carcinoma". J. Clin. Oneal., 1988, 6, 983.

[5] Baker T. R., PiverM . S., Hempling R. E.:'The addition of etoposide and ifosfamide to cisplatin as second line therapy in ovarian carcinoma". Eur. J. Gynecol. Oncol., 1993, 14, 18.

[6] Goldberg J.M., Piver M. S., Hempling R. E., Recio F. O.: "Paclitaxel and cisplatin combination chemotherapy in recurrent epithelial ovarian cancer". Gynecol. Oneal., 1996, 63, 312.

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