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Ovarian capillary hemangioma and stromal luteinization: a case study with hormonal receptor evaluation

  • D. Miliaras1,3,*,
  • S. Papaemmanouil1
  • G. Blatzas2

1Department of Pathology, Greece

2Division of Surgery, General Clinic of Thessaloniki, Greece

3Laboratory of Histology and Embryology, Medical Faculty, Aristotelian University, Thessaloniki, Greece

DOI: 10.12892/ejgo200105369 Vol.22,Issue 5,September 2001 pp.369-371

Published: 10 September 2001

*Corresponding Author(s): D. Miliaras E-mail:

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Abstract

Background: Ovarian hemangiomas are rare tumors, most of them asymptomatic, and of the cavernous type. Six of the reported cases were accompanied by stromal luteinization. There is a debate whether these luteinized cells promote the growth of the vascular lesion or just represent a stromal reaction.

Case: A 71-year-old female was incidentally found to have a small capillary hemangioma in her left ovary, surrounded by a rim of luteinized stromal cells. Immunohistochemical investigation revealed the presence of estrogen and progesterone receptors in the endothelial cells of the lesion.

Conclusion: Our histological and immunohistochemical findings, as well as data from the literature, support the view that at least some vascular lesions may result from hormonal stimulation.

Cite and Share

D. Miliaras,S. Papaemmanouil,G. Blatzas. Ovarian capillary hemangioma and stromal luteinization: a case study with hormonal receptor evaluation. European Journal of Gynaecological Oncology. 2001. 22(5);369-371.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200105369

References

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[2] Carder P. J., Goudlesbrough D. R.: "Ovarian hemangiomas and stromal luteinization". Histopathology, 1995, 26,585.

[3] Gehring P. A., Fowler W. C., Lininger R. A.: "Ovarian capillary hemangioma presenting as an adnexal mass with massive ascites and elevated CA-125". Gynecol. Oneal., 2000, 76, 130.

[4] Yamawaki T., Hirai Y.,Takeshima N., Hasumi K.: "Ovarian hemangioma associated with concominant stromal luteinization and ascites". Gynecol. Oncol., 1996, 61, 438.

[5] Lawhead R. A., Copeland L. J., Edwards C. L.: "Bilateral ovanan hemangiomas associated with diffuse abdominopelvic hemangiomatosis". Ohstet. Gynecol., 1985, 65, 597.

[6] Dean P. J., Haggitt R. C., O'Hara C. J.: "Malignant epithelioid hemangioendothelioma of the liver in young women: relationship to oral contraceptive use". Am. J. Surf?. Pathol., 1985, 9, 695.

[7] Makela S.,S avolainen H.,A avik E.,M yllarniemi M.,S trauss L., Ta skinen E. et al.: "Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors a and B". Proc. Natl. Acad. Sci. U.S.A., 1999, 96, 7077.

[8] Mueller M. D.,V igne J.-L.,M inchenko A.,L ebovic D. I., Leitman D. C., Taylor R. N.: "Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors a and B Proc. Natl. Acad. Sci. U.S.A., 2000, 97, 10972.

[9] Russell K. S., Haynes M. P., Sinha D., Clerisme E., Bender J. R.: "Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling". Proc Natl. Acad. Sci. U.S.A., 2000, 97, 5930.

[10] Scully R.E.: "Ovarian tumours with functioning stroma". In: Fox H. (ed.): Obstetrical & Gynaecological Pathology, 3nd ed. Churchill Livingstone, Edinburgh, 1987, 724.

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