Article Data

  • Views 209
  • Dowloads 107

Original Research

Open Access

ASCUS: comparative follow-up results related to previous SIL diagnosis

  • F. Alameda1,*,
  • P. Fuste1
  • M. Conangla1
  • E. Gimf errer1
  • I. Soler1
  • M. T. An torn1
  • S. Persico1
  • R. Carreras1
  • S. Serrano1

1Depts of Pathology and Obstetrics and Gynecology Hospital del Mar. Autonomous University of Barcelona, Barcelona, Spain

DOI: 10.12892/ejgo20000181 Vol.21,Issue 1,January 2000 pp.81-83

Published: 10 January 2000

*Corresponding Author(s): F. Alameda E-mail: XXX

Abstract

The clinical significance of ASCUS (atypical squamous cells of undetermined significance) remains undetermined. In a variety of cases, it is possible to identify an underlying neoplastic squamous lesion. With the aim of establishing some rationale basis for management, we have evaluated the history and the follow-up of 137 woman diagnosed with ASCUS. These woman were distributed into two groups, with or without history of SIL (30 and 107 woman, respectively); 38 woman did not come to the control. In general, the rate was 30.3% for low grade SIL (squamous intraepithelial lesions) and 6.1% for high grade SIL. In both groups the rate of low and high grade SIL was similar. In our opinion, women that are diagnosed with ASCUS must be submitted to colposcopic exams independently of their history.

Keywords

ASCUS; SIL; Dysplasia; Follow-up; Clinical significance


Cite and Share

F. Alameda,P. Fuste,M. Conangla,E. Gimf errer,I. Soler,M. T. An torn,S. Persico,R. Carreras,S. Serrano. ASCUS: comparative follow-up results related to previous SIL diagnosis. European Journal of Gynaecological Oncology. 2000. 21(1);81-83.

References

[1] Solomon D., Frable W. J., Vooijs G. P., Wilbur D. C., Amma N. S., Collins R. J., Davey D. D., et al.: "ASCUS and AGUS criteria". International Academy of Cytology Task Force Summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial. Acta Cytol., 1998 Jan.-Feb., 42 (1), 16.

[2] Abati A., Jaffurs W., Wilder A. M.: "Squamous atypia in the atrophic cervical vaginal smear: a new look at an old problem". Cancer, 1998 Aug. 25, 84 (4), 218.

[3] Howell L. P., Davis R. L.: "Follow-up of Papanicolaou smears diagnosed as atypical squamous cells of undetermined significance". Diagn. Cytopathol. ,1996 Feb., 14 (1), 20.

[4] Gonzalez D., Hernandez E., Anderson L., Heller P., Atkinson B. F.: "Clinical significance of a cervical cytologic diagnosis of atypical squamous cell of undetermined significance. Favoring a reactive process or low grade squamous intraepithelial lesion". J. Rep rod. Med., 1996 Oct., 41 (10), 719.

[5] Kline M. J., Davey D. D.: Atypical squamous cells of undetermined significance qualified: a follow-up study". Diagn. Cytopathol., 1996 Jun., 14 (4), 380.

[6] Davey D. D., Nielsen M. L., Naryshkin S., Robb J. A., Cohen T., Kline T. S.: "Atypical squamous cells of undetermined significance. Current laboratory practices of participants in the College of American Pathologists Interlaboratory. Comparison Program in Cervicovaginal Cytology". Arch. Pathol. Lab. Med., 1996 May, 120 (5), 440.

[7] Selvaggi S. M., Haefner H. K.: "Reporting of atypical squamous cells of undetermined significance on cervical smears: is it significant?". Diagn. Cytopathol., 1995 Nov., 13 (4), 352.

[8] Melnikow J., Nuovo J., Willan A. R., Chan B. K., Howell L. P.: "Natural history of cervical squamous intraepithelial lesions: a meta-analysis". Obstet. Gynecol., 1998 Oct., 92 (4 Pt 2), 727.

[9] Yang M., Zachariah S.: "ASCUS on cervical cytologic smears. Clinical significance". J. Reprod. Med., 1997 Jun., 42 (6), 329.

[10] Alanen K. W., Elit L. M., Molinaro P. A., McLachlin C. M.: "Assessment of cytologic follow-up as the recommended management for patients with atypical squamous cells of undetermined significance or low grade squamous intraepithelial lesions". Cancer, 1998 Feb. 25, 84 (1), 5.

[11] Cecchini S., Iossa A., Bonardi R., Ciatto S., Cariaggi P.: "Comparing two modalities of management of women with cytologic evidence of squamous or glandular atypia: early repeat cytology or colposcopy". Tumori, 1997 Jul-Aug., 83(4), 732.

[12] Kobelin M. H., Kobelin C. G., Burke L., Lavin P., Niloff J.M., Kim Y. B.: "Incidence and predictors of cervical dysplasia in patients with minimally abnormal Papanicolaou smears". Obstet. Gynecol., 1998 Sep., 92 (3), 356.

[13] Ferris D. G., Wright T. C. Jr., Litaker M. S., Richart R. M., Lorincz A. T., Sun X. W., Woodward L.: "Comparison of two tests for detecting carcinogenic HPV in women with Papanicolaou smear reports of ASCUS and LSIL". J. Fam. Pract., 1998 Feb., 46 (2), 136.

[14] Williams M. L., Rimm D. L., Pedigo M. A., Frable W. J.: "Atypical squamous cells of undertermined significance: correlative histologic and follow-up studies from an academic medical center". Diagn. Cytopathol., 1997 Jan., 16 (1), 1.

[15] Melnikow J., Nuovo J., Paliescheskey M., Stewart G. K., Howell L., Green W.: "Detection of high-grade cervical dysplasia: impact of age and Bethesda system terminology". Diagn. Cytopathol., 1997 Nov., 17 (5), 321.

[16] Rader A. E., Lazebnik R., Arora C. D., Franklin J., AbdulKarim F. W.: "Atypical squamous cells of undertermined significance in the pediatric population. Implications for management and comparison with the adult population". Acta Cytol., 1997 Jul.-Aug., 41 (4), 1073.

[17] Ghoussoub R. A., Rimm D. L.: "Degree of dysplasia following diagnosis of atypical squamous cells of undetennined significance is influenced by patient history and type of follow-up". Diagn. Cytopathol., 1997 Jul., 17 (1), 14

[18] Eskridge C., Begneaud W. P., Landwehr C.: "Cervicography combined with repeat Papanicolaou test as triage for lowgrade cytologic abnormalities". Obstet. Gynecol., 1998 Sep., 92 (3), 351.

[19] Recio F. O., S汕ai Srivastava B. I., Wong C., Hempling R. E., Eltabbakh G. H., Piver M. S.: "The clinical value of digene hybrid capture HPV DNA testing in a referral-based population with abnormal pap smears". Eur. J. Gynaecol. Oncol., 1998, 19 (3), 203.

[20] Autillo-Touati A., Joannes M., d'Ercole C., RobagliaSchlupp A., Lambert A., Mazzella E., Blanc B., Seite R.: "HPV typing by in situ hybridization on cervical cytologic smears with ASCUS". Acta Cytol., 1998 May-Jun., 42 (3), 631.

[21] Ferris D. G., Wright T. C. Jr., Litaker M. S., Richart R. M., Lorincz A. T., Sun X. W., Borgatta L. et al.: "Triage of women with ASCUS and LSIL on Pap smear reports: management by repeat Pap smear, HPV DNA testing, or colposcopy?". J. Fam. Pract., 1998 Feb., 46 (2), 125.

[22] Dunton C. J., van Hoeven K. H., Kovatich A. J., Oliver R. E., Scacheri R. Q., Cater J. R., Carlson J. A. Jr.: "Ki-67 antigen scacning as an adjunct to identifying cervical intraepithelial neoplasia". Gynecol. Oncol., 1997 Mar., 64 (3), 451.

[23] Sherman M. E., Schiffman M. H., Lorincz A. T., Herrero R., Hutchinson M. L., Bratti C., Zahniser D. et al.: "Cervical specimens collected in liquid buffer are suitable for both cytologic screening and ancillary human papillomavirus testing". Cancer, 1997 Apr. 25, 81 (2), 89.

[24] Duncan I. D.: "Guidelines for clinical practice and programme management". Oxford: National Co-ordinating Network, NHS Cervical Screening Programme, 1993.

[25] American College of Obstetricians and Gynecologists Committee on Quality Assessment: "ACOG criteria set. Atypical squamous cells of undetermined significance (ASCUS)". Int. J. Gynaecol. Obstet., 1996 Feb., 52 (2), 215.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top